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Results: 1-19 |
Results: 19
AG3340, A NOVEL MMP INHIBITOR, HAS A SUPERIOR THERAPEUTIC INDEX TO CARBOPLATIN IN NUDE-MICE BEARING CHEMORESISTANT HUMAN MV522 LUNG-CANCER TUMORS
Authors: SHALINSKY D BREKKEN J ZOU H BLOOM L MCDERMOTT C APPELT K VARKI NM
Citation: D. Shalinsky et al., AG3340, A NOVEL MMP INHIBITOR, HAS A SUPERIOR THERAPEUTIC INDEX TO CARBOPLATIN IN NUDE-MICE BEARING CHEMORESISTANT HUMAN MV522 LUNG-CANCER TUMORS, Annals of oncology, 9, 1998, pp. 278-278
RODENT PHARMACOKINETIC AND ANTITUMOR EFFICACY STUDIES WITH A SERIES OF SYNTHETIC INHIBITORS OF MATRIX METALLOPROTEINASES
Authors: SANTOS O MCDERMOTT CD DANIELS RG APPELT K
Citation: O. Santos et al., RODENT PHARMACOKINETIC AND ANTITUMOR EFFICACY STUDIES WITH A SERIES OF SYNTHETIC INHIBITORS OF MATRIX METALLOPROTEINASES, Clinical & experimental metastasis, 15(5), 1997, pp. 499-508
VIRACEPT (NELFINAVIR MESYLATE, AG1343) - A POTENT, ORALLY BIOAVAILABLE INHIBITOR OF HIV-1 PROTEASE
Authors: KALDOR SW KALISH VJ DAVIES JF SHETTY BV FRITZ JE APPELT K BURGESS JA CAMPANALE KM CHIRGADZE NY CLAWSON DK DRESSMAN BA HATCH SD KHALIL DA KOSA MB LUBBEHUSEN PP MUESING MA PATICK AK REICH SH SU KS TATLOCK JH
Citation: Sw. Kaldor et al., VIRACEPT (NELFINAVIR MESYLATE, AG1343) - A POTENT, ORALLY BIOAVAILABLE INHIBITOR OF HIV-1 PROTEASE, Journal of medicinal chemistry, 40(24), 1997, pp. 3979-3985
MMP INHIBITION-KINETICS AND PROTEIN-STRUCTURE - IMPLICATION FOR THE SLOW-BINDING OF INHIBITORS TO MATRILYSIN AND STROMELYSIN
Authors: HOWLAND EF APPELT K BROWNER M MARGOSIAK SA
Citation: Ef. Howland et al., MMP INHIBITION-KINETICS AND PROTEIN-STRUCTURE - IMPLICATION FOR THE SLOW-BINDING OF INHIBITORS TO MATRILYSIN AND STROMELYSIN, The FASEB journal, 10(6), 1996, pp. 756-756
ANTIVIRAL AND RESISTANCE STUDIES OF AG1343, AN ORALLY BIOAVAILABLE INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE (VOL 40, PG 294, 1996)
Authors: PATICK AK MO H MARKOWITZ M APPELT K WU B MUSICK L KALISH V KALDOR S REICH S HO D WEBBER S
Citation: Ak. Patick et al., ANTIVIRAL AND RESISTANCE STUDIES OF AG1343, AN ORALLY BIOAVAILABLE INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE (VOL 40, PG 294, 1996), Antimicrobial agents and chemotherapy, 40(6), 1996, pp. 1575-1575
ANTIVIRAL AND RESISTANCE STUDIES OF AG1343, AN ORALLY BIOAVAILABLE INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE
Authors: PATICK AK MARKOWITZ M APPELT K WU B MUSICK L KALISH V KALDOR S REICH S HO D WEBBER S
Citation: Ak. Patick et al., ANTIVIRAL AND RESISTANCE STUDIES OF AG1343, AN ORALLY BIOAVAILABLE INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE, Antimicrobial agents and chemotherapy, 40(2), 1996, pp. 292-297
STRUCTURE-BASED DESIGN OF LIPOPHILIC QUINAZOLINE INHIBITORS OF THYMIDYLATE SYNTHASE
Authors: JONES TR VARNEY MD WEBBER SE LEWIS KK MARZONI GP PALMER CL KATHARDEKAR V WELSH KM WEBBER S MATTHEWS DA APPELT K SMITH WW JANSON CA VILLAFRANCA JE BACQUET RJ HOWLAND EF BOOTH CLJ HERRMANN SM WARD RW WHITE J MOOMAW EW BARTLETT CA MORSE CA
Citation: Tr. Jones et al., STRUCTURE-BASED DESIGN OF LIPOPHILIC QUINAZOLINE INHIBITORS OF THYMIDYLATE SYNTHASE, Journal of medicinal chemistry, 39(4), 1996, pp. 904-917
STRUCTURE-BASED DESIGN AND SYNTHESIS OF SUBSTITUTED 2-BUTANOLS AS NONPEPTIDIC INHIBITORS OF HIV PROTEASE - SECONDARY AMIDE SERIES
Authors: REICH SH MELNICK M PINO MJ FUHRY MAM TRIPPE AJ APPELT K DAVIES JF WU BW MUSICK L
Citation: Sh. Reich et al., STRUCTURE-BASED DESIGN AND SYNTHESIS OF SUBSTITUTED 2-BUTANOLS AS NONPEPTIDIC INHIBITORS OF HIV PROTEASE - SECONDARY AMIDE SERIES, Journal of medicinal chemistry, 39(14), 1996, pp. 2781-2794
BIS TERTIARY AMIDE INHIBITORS OF THE HIV-1 PROTEASE GENERATED VIA PROTEIN STRUCTURE-BASED ITERATIVE DESIGN
Authors: MELNICK M REICH SH LEWIS KK MITCHELL LJ NGUYEN D TRIPPE AJ DAWSON H DAVIES JF APPELT K WU BW MUSICK L GEHLHAAR DK WEBBER S SHETTY B KOSA M KAHIL D ANDRADA D
Citation: M. Melnick et al., BIS TERTIARY AMIDE INHIBITORS OF THE HIV-1 PROTEASE GENERATED VIA PROTEIN STRUCTURE-BASED ITERATIVE DESIGN, Journal of medicinal chemistry, 39(14), 1996, pp. 2795-2811
A SYSTEMATIC STUDY OF P-1-P-3 SPANNING SIDE-CHAINS FOR THE INHIBITIONOF HIV-1 PROTEASE
Authors: KALDOR SW APPELT K FRITZ JE HAMMOND M CROWELL TA BAXTER AJ HATCH SD WISKERCHEN M MUESING MA
Citation: Sw. Kaldor et al., A SYSTEMATIC STUDY OF P-1-P-3 SPANNING SIDE-CHAINS FOR THE INHIBITIONOF HIV-1 PROTEASE, Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 715-720
ISOPHTHALIC ACID-DERIVATIVES - AMINO-ACID SURROGATES FOR THE INHIBITION OF HIV-1 PROTEASE
Authors: KALDOR SW DRESSMAN BA HAMMOND M APPELT K BURGESS JA LUBBEHUSEN PP MUESING MA HATCH SD WISKERCHEN MA BAXTER AJ
Citation: Sw. Kaldor et al., ISOPHTHALIC ACID-DERIVATIVES - AMINO-ACID SURROGATES FOR THE INHIBITION OF HIV-1 PROTEASE, Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 721-726
STRUCTURE-BASED DRUG DESIGN OF NONPEPTIDIC P-2 SUBSTITUENTS FOR HIV-1PROTEASE INHIBITORS
Authors: KALISH VJ TATLOCK JH DAVIES JF KALDOR SW DRESSMAN BA REICH S PINO M NYUGEN D APPELT K MUSICK L WU BW
Citation: Vj. Kalish et al., STRUCTURE-BASED DRUG DESIGN OF NONPEPTIDIC P-2 SUBSTITUENTS FOR HIV-1PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 727-732
EMPIRICAL FREE-ENERGY CALCULATIONS OF LIGAND-PROTEIN CRYSTALLOGRAPHICCOMPLEXES .1. KNOWLEDGE-BASED LIGAND-PROTEIN INTERACTION POTENTIALS APPLIED TO THE PREDICTION OF HUMAN-IMMUNODEFICIENCY-VIRUS-1 PROTEASE BINDING-AFFINITY
Authors: VERKHIVKER G APPELT K FREER ST VILLAFRANCA JE
Citation: G. Verkhivker et al., EMPIRICAL FREE-ENERGY CALCULATIONS OF LIGAND-PROTEIN CRYSTALLOGRAPHICCOMPLEXES .1. KNOWLEDGE-BASED LIGAND-PROTEIN INTERACTION POTENTIALS APPLIED TO THE PREDICTION OF HUMAN-IMMUNODEFICIENCY-VIRUS-1 PROTEASE BINDING-AFFINITY, Protein engineering, 8(7), 1995, pp. 677-691
ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS
Authors: KALISH V KALDOR S SHETTY B TATLOCK J DAVIES J HAMMOND M DRESSMAN B FRITZ J APPELT K REICH S MUSICK L WU BW SU K
Citation: V. Kalish et al., ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS, European journal of medicinal chemistry, 30, 1995, pp. 201-214
PROTEIN STRUCTURE-BASED DESIGN OF POTENT ORALLY BIOAVAILABLE, NONPEPTIDE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE
Authors: REICH SH MELNICK M DAVIES JF APPELT K LEWIS KK FUHRY MA PINO M TRIPPE AJ NGUYEN D DAWSON H WU BW MUSICK L KOSA M KAHIL D WEBBER S GEHLHAAR DK ANDRADA D SHETTY B
Citation: Sh. Reich et al., PROTEIN STRUCTURE-BASED DESIGN OF POTENT ORALLY BIOAVAILABLE, NONPEPTIDE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE, Proceedings of the National Academy of Sciences of the United Statesof America, 92(8), 1995, pp. 3298-3302
PURIFICATION OF THE ESCHERICHIA-COLI INTEGRATION HOST FACTOR (IHF) INONE CHROMATOGRAPHIC STEP
Authors: FILUTOWICZ M GRIMEK H APPELT K
Citation: M. Filutowicz et al., PURIFICATION OF THE ESCHERICHIA-COLI INTEGRATION HOST FACTOR (IHF) INONE CHROMATOGRAPHIC STEP, Gene, 147(1), 1994, pp. 149-150
CALCULATION OF RELATIVE DIFFERENCES IN THE BINDING FREE-ENERGIES OF HIV-1 PROTEASE INHIBITORS - A THERMODYNAMIC CYCLE PERTURBATION APPROACH
Authors: REDDY MR VARNEY MD KALISH V VISWANADHAN VN APPELT K
Citation: Mr. Reddy et al., CALCULATION OF RELATIVE DIFFERENCES IN THE BINDING FREE-ENERGIES OF HIV-1 PROTEASE INHIBITORS - A THERMODYNAMIC CYCLE PERTURBATION APPROACH, Journal of medicinal chemistry, 37(8), 1994, pp. 1145-1152
CRYSTAL-STRUCTURE-BASED DESIGN AND SYNTHESIS OF NOVEL C-TERMINAL INHIBITORS OF HIV PROTEASE
Authors: VARNEY MD APPELT K KALISH V REDDY MR TATLOCK J PALMER CL ROMINES WH WU BW MUSICK L
Citation: Md. Varney et al., CRYSTAL-STRUCTURE-BASED DESIGN AND SYNTHESIS OF NOVEL C-TERMINAL INHIBITORS OF HIV PROTEASE, Journal of medicinal chemistry, 37(15), 1994, pp. 2274-2284
INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Authors: HOSUR MV BHAT TN KEMPF DJ BALDWIN ET LIU BS GULNIK S WIDEBURG NE NORBECK DW APPELT K ERICKSON JW
Citation: Mv. Hosur et al., INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE, Journal of the American Chemical Society, 116(3), 1994, pp. 847-855
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