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Results: 1-9 |
Results: 9
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR
Authors: LYLE TA CHEN ZG APPLEBY SD FREIDINGER RM GARDELL SJ LEWIS SD LI Y LYLE EA LYNCH JJ MULICHAK AM NG AS NAYLOROLSEN AM SANDERS WM
Citation: Ta. Lyle et al., SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 67-72
SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ SISKO JT LYNCH JJ LYLE EA BASKIN EP WOLTMANN RF APPLEBY SD
Citation: Tj. Tucker et al., SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION, Journal of medicinal chemistry, 40(22), 1997, pp. 3687-3693
POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ BASKIN EP WOLTMANN R LYNCH JJ LYLE EA APPLEBY SD CHEN IW DANCHECK KB VACCA JP
Citation: Tj. Tucker et al., POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY, Journal of medicinal chemistry, 40(11), 1997, pp. 1565-1569
LACK OF BENEFICIAL-EFFECTS OF GROWTH-HORMONE TREATMENT IN CONSCIOUS DOGS DURING THE DEVELOPMENT OF CONGESTIVE-HEART-FAILURE
Authors: SHEN YT WOLTMANN RF APPLEBY SD VOLKSDORF SR PRAHALADA S KRAUSE SM KIVLIGHN SD JOHNSON RG SIEGL PK LYNCH JJ
Citation: Yt. Shen et al., LACK OF BENEFICIAL-EFFECTS OF GROWTH-HORMONE TREATMENT IN CONSCIOUS DOGS DURING THE DEVELOPMENT OF CONGESTIVE-HEART-FAILURE, Circulation, 96(8), 1997, pp. 2768-2768
INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES
Authors: LEWIS SD NG AS LYLE EA MELLOTT MJ APPLEBY SD BRADY SF STAUFFER KJ SISKO JT MAO SS VEBER DF NUTT RF LYNCH JJ COOK JJ GARDELL SJ SHAFER JA
Citation: Sd. Lewis et al., INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES, Thrombosis and haemostasis, 74(4), 1995, pp. 1107-1112
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF TEDISAMIL
Authors: WALLACE AA STUPIENSKI RF BASKIN EP APPLEBY SD KOTHSTEIN T GEHRET JR KING SW REMY DC LYNCH JJ
Citation: Aa. Wallace et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF TEDISAMIL, The Journal of pharmacology and experimental therapeutics, 273(1), 1995, pp. 168-175
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 2 LONG-ACTING SPIROBENZOPYRAN PIPERIDINE CLASS-III AGENTS, L-702,958 AND L-706,000[MK-499]
Authors: LYNCH JJ WALLACE AA STUPIENSKI RF BASKIN EP BEARE CM APPLEBY SD SALATA JJ JURKIEWICZ NK SANGUINETTI MC STEIN RB GEHRET JR KOTHSTEIN T CLAREMON DA ELLIOTT JM BUTCHER JW REMY DC BALDWIN JJ
Citation: Jj. Lynch et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 2 LONG-ACTING SPIROBENZOPYRAN PIPERIDINE CLASS-III AGENTS, L-702,958 AND L-706,000[MK-499], The Journal of pharmacology and experimental therapeutics, 269(2), 1994, pp. 541-554
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL) AMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE HCL (L-691, 121), A NOVEL CLASS-III AGENT
Authors: LYNCH JJ WALLACE AA VANDERGAAG LH BASKIN EP BEAR CM GEHRET JR KOTHSTEIN T STUPIENSKI RF APPLEBY SD SANGUINETTI MC JURKIEWICZ NK ZINGARO GJ STEIN RB CLAREMON DA ELLIOTT JM YOUNG MB BALDWIN JJ
Citation: Jj. Lynch et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL) AMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE HCL (L-691, 121), A NOVEL CLASS-III AGENT, The Journal of pharmacology and experimental therapeutics, 265(2), 1993, pp. 720-730
Risultati: 1-9 |