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Results: 1-20 |
Results: 20
Destabilization of steroid receptors by heat shock protein 90-binding drugs: A ligand-independent approach to hormonal therapy of breast cancer
Authors: Bagatell, R Khan, O Paine-Murrieta, G Taylor, CW Akinaga, S Whitesell, L
Citation: R. Bagatell et al., Destabilization of steroid receptors by heat shock protein 90-binding drugs: A ligand-independent approach to hormonal therapy of breast cancer, CLIN CANC R, 7(7), 2001, pp. 2076-2084
UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery
Authors: Abe, S Kubota, T Otani, Y Furukawa, T Watanabe, M Kumai, K Akiyama, T Akinaga, S Kitajima, M
Citation: S. Abe et al., UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery, JPN J CANC, 92(5), 2001, pp. 537-545
Chrolactomycin, a novel antitumor antibiotic produced by Streptomyces sp.
Authors: Nakai, R Kakita, S Asai, A Chiba, S Akinaga, S Mizukami, T Yamashita, Y
Citation: R. Nakai et al., Chrolactomycin, a novel antitumor antibiotic produced by Streptomyces sp., J ANTIBIOT, 54(10), 2001, pp. 836-839
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of Hsp90-binding agents
Authors: Bagatell, R Paine-Murrieta, GD Taylor, CW Pulcini, EJ Akinaga, S Benjamin, IJ Whitesell, L
Citation: R. Bagatell et al., Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of Hsp90-binding agents, CLIN CANC R, 6(8), 2000, pp. 3312-3318
Therapeutic potential of chimeric anti-(ganglioside GD3) antibody KM871: antitumor activity in xenograft model of melanoma and effector function analysis
Authors: Kanazawa, J Ohta, S Shitara, K Fujita, F Fujita, M Hanai, N Akinaga, S Okabe, M
Citation: J. Kanazawa et al., Therapeutic potential of chimeric anti-(ganglioside GD3) antibody KM871: antitumor activity in xenograft model of melanoma and effector function analysis, CANCER IMMU, 49(4-5), 2000, pp. 253-258
UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a newgeneration of anti-cancer agents for the new century?
Authors: Akinaga, S Sugiyama, K Akiyama, T
Citation: S. Akinaga et al., UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a newgeneration of anti-cancer agents for the new century?, ANTI-CAN DR, 15(1), 2000, pp. 43-52
UCS1025A, a novel antibiotic produced by Acremonium sp.
Authors: Nakai, R Ogawa, H Asai, A Ando, K Agatsuma, T Matsumiya, S Akinaga, S Yamashita, Y Mizukami, T
Citation: R. Nakai et al., UCS1025A, a novel antibiotic produced by Acremonium sp., J ANTIBIOT, 53(3), 2000, pp. 294-296
UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation
Authors: Sugiyama, K Shimizu, M Akiyama, T Tamaoki, T Yamaguchi, K Takahashi, R Eastman, A Akinaga, S
Citation: K. Sugiyama et al., UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation, INT J CANC, 85(5), 2000, pp. 703-709
Retinoblastoma protein-initiated cellular growth arrest overcomes the ability of cotransfected wild-type p53 to induce apoptosis
Authors: Shinohara, H Zhou, J Yoshikawa, K Yazumi, S Ko, K Yamaoka, Y Mizukami, T Yoshida, T Akinaga, S Tamaoki, T Motoda, H Benedict, WF Takahashi, R
Citation: H. Shinohara et al., Retinoblastoma protein-initiated cellular growth arrest overcomes the ability of cotransfected wild-type p53 to induce apoptosis, BR J CANC, 83(8), 2000, pp. 1039-1046
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex
Authors: Shiotsu, Y Neckers, LM Wortman, I An, WG Schulte, TW Soga, S Murakata, C Tamaoki, T Akinaga, S
Citation: Y. Shiotsu et al., Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex, BLOOD, 96(6), 2000, pp. 2284-2291
Chemoprotective effects of KF41399, a derivative of carbazole compounds, on nimustine-induced thrombocytopenia
Authors: Shiotsu, Y Yamashita, K Kanai, F Ikuina, Y Murakata, C Teramura, M Mizoguchi, H Tamaoki, T Akinaga, S
Citation: Y. Shiotsu et al., Chemoprotective effects of KF41399, a derivative of carbazole compounds, on nimustine-induced thrombocytopenia, BLOOD, 95(12), 2000, pp. 3771-3780
Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycleprogression and CDC2 cyclin B-1 regulation in A431 cells synchronized at Mphase by nocodazole
Authors: Akiyama, T Shimizu, M Okabe, W Tamaoki, T Akinaga, S
Citation: T. Akiyama et al., Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycleprogression and CDC2 cyclin B-1 regulation in A431 cells synchronized at Mphase by nocodazole, ANTI-CANC D, 10(1), 1999, pp. 67-78
G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation
Authors: Akiyama, T Sugiyama, K Shimizu, M Tamaoki, T Akinaga, S
Citation: T. Akiyama et al., G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation, JPN J CANC, 90(12), 1999, pp. 1364-1372
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones
Authors: Schulte, TW Akinaga, S Murakata, T Agatsuma, T Sugimoto, S Nakano, H Lee, YS Simen, BB Argon, Y Felts, S Toft, DO Neckers, LM Sharma, SV
Citation: Tw. Schulte et al., Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones, MOL ENDOCR, 13(9), 1999, pp. 1435-1448
Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor,UCN-01
Authors: Kurata, N Kuwabara, T Tanii, H Fuse, E Akiyama, T Akinaga, S Kobayashi, H Yamaguchi, K Kobayashi, S
Citation: N. Kurata et al., Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor,UCN-01, CANC CHEMOT, 44(1), 1999, pp. 12-18
Decrease in susceptibility toward induction of apoptosis and alteration inG(1) checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-hydroxystaurosporine)
Authors: Sugiyama, K Akiyama, T Shimizu, M Tamaoki, T Courage, C Gescher, A Akinaga, S
Citation: K. Sugiyama et al., Decrease in susceptibility toward induction of apoptosis and alteration inG(1) checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-hydroxystaurosporine), CANCER RES, 59(17), 1999, pp. 4406-4412
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumoractivity via selective depletion of Hsp90 binding signaling molecules
Authors: Soga, S Neckers, LM Schulte, TW Shiotsu, Y Akasaka, K Narumi, H Agatsuma, T Ikuina, Y Murakata, C Tamaoki, T Akinaga, S
Citation: S. Soga et al., KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumoractivity via selective depletion of Hsp90 binding signaling molecules, CANCER RES, 59(12), 1999, pp. 2931-2938
Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration
Authors: Takahashi, T Kanazawa, J Akinaga, S Tamaoki, T Okabe, M
Citation: T. Takahashi et al., Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration, CANC CHEMOT, 43(3), 1998, pp. 233-240
A pure antiestrogen, ICI 182,780, stimulates the growth of tamoxifen-resistant KPL-1 human breast cancer cells in vivo but not in vitro
Authors: Kurebayashi, J Otsuki, T Yamamoto, S Kurosumi, M Nakata, T Akinaga, S Sonoo, H
Citation: J. Kurebayashi et al., A pure antiestrogen, ICI 182,780, stimulates the growth of tamoxifen-resistant KPL-1 human breast cancer cells in vivo but not in vitro, ONCOL-BASEL, 55, 1998, pp. 23-33
Combined effect of navelbine with medroxyprogesterone acetate against human breast carcinoma MCF-7 cells in vitro
Authors: Sugiyama, K Shimizu, M Akiyama, T Ishida, H Okabe, M Tamaoki, T Akinaga, S
Citation: K. Sugiyama et al., Combined effect of navelbine with medroxyprogesterone acetate against human breast carcinoma MCF-7 cells in vitro, BR J CANC, 77(11), 1998, pp. 1737-1743
Risultati: 1-20 |