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Results: 1-25/32
Authors:
Lee, MJ
Thangada, S
Paik, JH
Sapkota, GP
Ancellin, N
Chae, SS
Wu, MT
Morales-Ruiz, M
Sessa, WC
Alessi, DR
Hla, T
Citation: Mj. Lee et al., Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis, MOL CELL, 8(3), 2001, pp. 693-704
Authors:
Zhang, MY
Barber, DL
Alessi, DR
Bell, LL
Stine, C
Nguyen, MHH
Beattie, BK
Cheung, JY
Miller, BA
Citation: My. Zhang et al., A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation, EXP HEMATOL, 29(4), 2001, pp. 432-440
Authors:
Alessi, DR
Citation: Dr. Alessi, Discovery of PDKI, one of the missing links in insulin signal transduction, BIOCH SOC T, 29, 2001, pp. 1-14
Authors:
Thomas, CC
Dowler, S
Deak, M
Alessi, DR
van Aalten, DMF
Citation: Cc. Thomas et al., Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity, BIOCHEM J, 358, 2001, pp. 287-294
Authors:
Wang, XM
Li, W
Williams, M
Terada, N
Alessi, DR
Proud, CG
Citation: Xm. Wang et al., Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase, EMBO J, 20(16), 2001, pp. 4370-4379
Authors:
Biondi, RM
Kieloch, A
Currie, RA
Deak, M
Alessi, DR
Citation: Rm. Biondi et al., The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK,but not PKB, EMBO J, 20(16), 2001, pp. 4380-4390
Authors:
Mora, A
Sabio, G
Gonzalez-Polo, RA
Cuenda, A
Alessi, DR
Alonso, JC
Fuentes, JM
Soler, G
Centeno, F
Citation: A. Mora et al., Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells, J NEUROCHEM, 78(1), 2001, pp. 199-206
Authors:
Lawlor, MA
Alessi, DR
Citation: Ma. Lawlor et Dr. Alessi, PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?, J CELL SCI, 114(16), 2001, pp. 2903-2910
Authors:
Sapkota, GP
Kieloch, A
Lizcano, JM
Lain, S
Arthur, JSC
Williams, MR
Morrice, N
Deak, M
Alessi, DR
Citation: Gp. Sapkota et al., Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser(431) by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth, J BIOL CHEM, 276(22), 2001, pp. 19469-19482
Authors:
Leslie, NR
Biondi, RM
Alessi, DR
Citation: Nr. Leslie et al., Phosphoinositide-regulated kinases and phosphoinositide phosphatases, CHEM REV, 101(8), 2001, pp. 2365-2380
Authors:
Williams, MR
Arthur, JSC
Balendran, A
van der Kaay, J
Poli, V
Cohen, P
Alessi, DR
Citation: Mr. Williams et al., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells, CURR BIOL, 10(8), 2000, pp. 439-448
Authors:
Dowler, S
Currie, RA
Campbell, DG
Deak, M
Kular, G
Downes, CP
Alessi, DR
Citation: S. Dowler et al., Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities, BIOCHEM J, 351, 2000, pp. 19-31
Authors:
Dowler, S
Montalvo, L
Cantrell, D
Morrice, N
Alessi, DR
Citation: S. Dowler et al., Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase, BIOCHEM J, 349, 2000, pp. 605-610
Authors:
Deprez, J
Bertrand, L
Alessi, DR
Krause, U
Hue, L
Rider, MH
Citation: J. Deprez et al., Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase, BIOCHEM J, 347, 2000, pp. 305-312
Authors:
Vanhaesebroeck, B
Alessi, DR
Citation: B. Vanhaesebroeck et Dr. Alessi, The P13K-PDK1 connection: more than just a road to PKB, BIOCHEM J, 346, 2000, pp. 561-576
Authors:
Biondi, RM
Cheung, PCF
Casamayor, A
Deak, M
Currie, RA
Alessi, DR
Citation: Rm. Biondi et al., Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA, EMBO J, 19(5), 2000, pp. 979-988
Authors:
Schmoll, D
Walker, KS
Alessi, DR
Grempler, R
Burchell, A
Guo, SD
Walther, R
Unterman, TG
Citation: D. Schmoll et al., Regulation of glucose-6-phosphatase gene expression by protein kinase B alpha and the forkhead transcription factor FKHR - Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity, J BIOL CHEM, 275(46), 2000, pp. 36324-36333
Authors:
Balendran, A
Biondi, RM
Cheung, PCF
Casamayor, A
Deak, M
Alessi, DR
Citation: A. Balendran et al., A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase C zeta (PKC zeta) and PKC-related kinase 2 by PDK1, J BIOL CHEM, 275(27), 2000, pp. 20806-20813
Authors:
Ryder, JW
Fahlman, R
Wallberg-Henriksson, H
Alessi, DR
Krook, A
Zierath, JR
Citation: Jw. Ryder et al., Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle - Involvement of the mitogen- and stress-activated protein kinase 1, J BIOL CHEM, 275(2), 2000, pp. 1457-1462
Authors:
Balendran, A
Hare, GR
Kieloch, A
Williams, MR
Alessi, DR
Citation: A. Balendran et al., Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1)is required for the stability and phosphorylation of protein kinase C (PKC) isoforms, FEBS LETTER, 484(3), 2000, pp. 217-223
Authors:
Grillo, S
Gremeaux, T
Casamayor, A
Alessi, DR
Le Marchand-Brustel, Y
Tanti, JF
Citation: S. Grillo et al., Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 - Potential involvement of Src kinase, EUR J BIOCH, 267(22), 2000, pp. 6642-6649
Authors:
Cuenda, A
Alessi, DR
Citation: A. Cuenda et Dr. Alessi, Use of kinase inhibitors to dissect signaling pathways, METH MOL B, 99, 2000, pp. 161-175
Authors:
Balendran, A
Casamayor, A
Deak, M
Paterson, A
Gaffney, P
Currie, R
Downes, CP
Alessi, DR
Citation: A. Balendran et al., PDK1 acquires PDK2 activity in the presence of a synthetic peptide derivedfrom the carboxyl terminus of PRK2, CURR BIOL, 9(8), 1999, pp. 393-404
Authors:
Casamayor, A
Torrance, PD
Kobayashi, T
Thorner, J
Alessi, DR
Citation: A. Casamayor et al., Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast, CURR BIOL, 9(4), 1999, pp. 186-197
Authors:
Nave, BT
Ouwens, DM
Withers, DJ
Alessi, DR
Shepherd, PR
Citation: Bt. Nave et al., Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation, BIOCHEM J, 344, 1999, pp. 427-431