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Results: 1-13 |
Results: 13
C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION
Authors: ISAACS RCA CUTRONA KJ NEWTON CL SANDERSON PEJ SOLINSKY MG BASKIN EP CHEN IW COOPER CM COOK JJ GARDELL SJ LEWIS SD LUCAS RJ LYLE EA LYNCH JJ NAYLOROLSEN AM STRANIERI MT VASTAG K VACCA JP
Citation: Rca. Isaacs et al., C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1719-1724
DIFFERENTIAL ATRIAL VERSUS VENTRICULAR ACTIVITIES OF CLASS-III POTASSIUM CHANNEL BLOCKERS
Authors: BASKIN EP LYNCH JJ
Citation: Ep. Baskin et Jj. Lynch, DIFFERENTIAL ATRIAL VERSUS VENTRICULAR ACTIVITIES OF CLASS-III POTASSIUM CHANNEL BLOCKERS, The Journal of pharmacology and experimental therapeutics, 285(1), 1998, pp. 135-142
DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION
Authors: TUCKER TJ BRADY SF LUMMA WC LEWIS SD GARDELL SJ NAYLOROLSEN AM YAN YW SISKO JT STAUFFER KJ LUCAS BJ LYNCH JJ COOK JJ STRANIERI MT HOLAHAN MA LYLE EA BASKIN EP CHEN IW DANCHECK KB KRUEGER JA COOPER CM VACCA JP
Citation: Tj. Tucker et al., DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION, Journal of medicinal chemistry, 41(17), 1998, pp. 3210-3219
RELATIONSHIP OF COLLATERAL VESSEL GROWTH AND RESERVE BLOOD-FLOW FOLLOWING HINDLIMB ISCHEMIA IN THE RABBIT
Authors: HERSHEY JC BASKIN EP GLASS JD HARTMAN HA COOK JJ
Citation: Jc. Hershey et al., RELATIONSHIP OF COLLATERAL VESSEL GROWTH AND RESERVE BLOOD-FLOW FOLLOWING HINDLIMB ISCHEMIA IN THE RABBIT, Circulation, 98(17), 1998, pp. 4160-4160
DISCOVERY OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS INCORPORATING AMINOPYRIDYL MOIETIES AT THE P1 POSITION
Authors: FENG DM GARDELL SJ LEWIS SD BOCK MG CHEN ZG FREIDINGER RM NAYLOROLSEN AM RAMJIT HG WOLTMANN R BASKIN EP LYNCH JJ LUCAS R SHAFER JA DANCHECK KB CHEN IW MAO SS KRUEGER JA HARE TR MULICHAK AM VACCA JP
Citation: Dm. Feng et al., DISCOVERY OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS INCORPORATING AMINOPYRIDYL MOIETIES AT THE P1 POSITION, Journal of medicinal chemistry, 40(23), 1997, pp. 3726-3733
SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ SISKO JT LYNCH JJ LYLE EA BASKIN EP WOLTMANN RF APPLEBY SD
Citation: Tj. Tucker et al., SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION, Journal of medicinal chemistry, 40(22), 1997, pp. 3687-3693
POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ BASKIN EP WOLTMANN R LYNCH JJ LYLE EA APPLEBY SD CHEN IW DANCHECK KB VACCA JP
Citation: Tj. Tucker et al., POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY, Journal of medicinal chemistry, 40(11), 1997, pp. 1565-1569
USE-DEPENDENT EFFECTS OF THE CLASS-III ANTIARRHYTHMIC AGENT NE-10064 (AZIMILIDE) ON CARDIAC REPOLARIZATION - BLOCK OF DELAYED RECTIFIER POTASSIUM AND L-TYPE CALCIUM CURRENTS
Authors: FERMINI B JURKIEWICZ NK JOW B GUINOSSO PJ BASKIN EP LYNCH JJ SALATA JJ
Citation: B. Fermini et al., USE-DEPENDENT EFFECTS OF THE CLASS-III ANTIARRHYTHMIC AGENT NE-10064 (AZIMILIDE) ON CARDIAC REPOLARIZATION - BLOCK OF DELAYED RECTIFIER POTASSIUM AND L-TYPE CALCIUM CURRENTS, Journal of cardiovascular pharmacology, 26(2), 1995, pp. 259-271
COMPARISON OF BINDING TO RAPIDLY ACTIVATING DELAYED RECTIFIER K-KR, AND EFFECTS ON MYOCARDIAL REFRACTORINESS FOR CLASS-III ANTIARRHYTHMIC AGENTS( CHANNEL, I)
Authors: LYNCH JJ BASKIN EP NUTT EM GUINOSSO PJ HAMILL T SALATA JJ WOODS CM
Citation: Jj. Lynch et al., COMPARISON OF BINDING TO RAPIDLY ACTIVATING DELAYED RECTIFIER K-KR, AND EFFECTS ON MYOCARDIAL REFRACTORINESS FOR CLASS-III ANTIARRHYTHMIC AGENTS( CHANNEL, I), Journal of cardiovascular pharmacology, 25(2), 1995, pp. 336-340
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF TEDISAMIL
Authors: WALLACE AA STUPIENSKI RF BASKIN EP APPLEBY SD KOTHSTEIN T GEHRET JR KING SW REMY DC LYNCH JJ
Citation: Aa. Wallace et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF TEDISAMIL, The Journal of pharmacology and experimental therapeutics, 273(1), 1995, pp. 168-175
COMPARATIVE EFFECTS OF INCREASED EXTRACELLULAR POTASSIUM AND PACING FREQUENCY ON THE CLASS-III ACTIVITIES OF METHANESULFONANILIDE I-KR BLOCKERS DOFETILIDE, D-SOTALOL, E-4031, AND MK-499
Authors: BASKIN EP LYNCH JJ
Citation: Ep. Baskin et Jj. Lynch, COMPARATIVE EFFECTS OF INCREASED EXTRACELLULAR POTASSIUM AND PACING FREQUENCY ON THE CLASS-III ACTIVITIES OF METHANESULFONANILIDE I-KR BLOCKERS DOFETILIDE, D-SOTALOL, E-4031, AND MK-499, Journal of cardiovascular pharmacology, 24(2), 1994, pp. 199-208
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 2 LONG-ACTING SPIROBENZOPYRAN PIPERIDINE CLASS-III AGENTS, L-702,958 AND L-706,000[MK-499]
Authors: LYNCH JJ WALLACE AA STUPIENSKI RF BASKIN EP BEARE CM APPLEBY SD SALATA JJ JURKIEWICZ NK SANGUINETTI MC STEIN RB GEHRET JR KOTHSTEIN T CLAREMON DA ELLIOTT JM BUTCHER JW REMY DC BALDWIN JJ
Citation: Jj. Lynch et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 2 LONG-ACTING SPIROBENZOPYRAN PIPERIDINE CLASS-III AGENTS, L-702,958 AND L-706,000[MK-499], The Journal of pharmacology and experimental therapeutics, 269(2), 1994, pp. 541-554
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL) AMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE HCL (L-691, 121), A NOVEL CLASS-III AGENT
Authors: LYNCH JJ WALLACE AA VANDERGAAG LH BASKIN EP BEAR CM GEHRET JR KOTHSTEIN T STUPIENSKI RF APPLEBY SD SANGUINETTI MC JURKIEWICZ NK ZINGARO GJ STEIN RB CLAREMON DA ELLIOTT JM YOUNG MB BALDWIN JJ
Citation: Jj. Lynch et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL) AMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE HCL (L-691, 121), A NOVEL CLASS-III AGENT, The Journal of pharmacology and experimental therapeutics, 265(2), 1993, pp. 720-730
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