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Results: 1-20 |
Results: 20
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries
Authors: Kumar, S Connor, JR Dodds, RA Halsey, W Van Horn, M Mao, J Sathe, G Mui, P Agarwal, P Badger, AM Lee, JC Gowen, M Lark, MW
Citation: S. Kumar et al., Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries, OSTEO CART, 9(7), 2001, pp. 641-653
Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia
Authors: Barone, FC Irving, EA Ray, AM Lee, JC Kassis, S Kumar, S Badger, AM Legos, JJ Erhardt, JA Ohlstein, EH Hunter, AJ Harrison, DC Philpott, K Smith, BR Adams, JL Parsons, AA
Citation: Fc. Barone et al., Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia, MED RES REV, 21(2), 2001, pp. 129-145
SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia
Authors: Barone, FC Irving, EA May, AM Lee, JC Kassis, S Kumar, S Badger, AM White, RF McVey, MJ Legos, JJ Erhardt, JA Nelson, AH Ohlstein, EH Hunter, AJ Ward, K Smith, BR Adams, JL Parsons, AA
Citation: Fc. Barone et al., SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia, J PHARM EXP, 296(2), 2001, pp. 312-321
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models
Authors: Ames, RS Lee, D Foley, JJ Jurewicz, AJ Tornetta, MA Bautsch, W Settmacher, B Klos, A Erhard, KF Cousins, RD Sulpizio, AC Hieble, JP McCafferty, G Ward, KW Adams, JL Bondinell, WE Underwood, DC Osborn, RR Badger, AM Sarau, HM
Citation: Rs. Ames et al., Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models, J IMMUNOL, 166(10), 2001, pp. 6341-6348
IL-1-and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase
Authors: Kumar, S Votta, BJ Rieman, DJ Badger, AM Gowen, M Lee, JC
Citation: S. Kumar et al., IL-1-and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase, J CELL PHYS, 187(3), 2001, pp. 294-303
In vitro models for investigation of the effects of acute mechanical injury on cartilage
Authors: Patwari, P Fay, J Cook, MN Badger, AM Kerin, AJ Lark, MW Grodzinsky, AJ
Citation: P. Patwari et al., In vitro models for investigation of the effects of acute mechanical injury on cartilage, CLIN ORTHOP, (391), 2001, pp. S61-S71
Disease-modifying activity of SB 273005, an orally active, nonpeptide alpha(v)beta(3) (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis
Authors: Badger, AM Blake, S Kapadia, R Sarkar, S Levin, J Swift, BA Hoffman, SJ Stroup, GB Miller, WH Gowen, M Lark, MW
Citation: Am. Badger et al., Disease-modifying activity of SB 273005, an orally active, nonpeptide alpha(v)beta(3) (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis, ARTH RHEUM, 44(1), 2001, pp. 128-137
Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocytecultures
Authors: Badger, AM Roshak, AK Cook, MN Newman-Tarr, TM Swift, BA Carlson, K Connor, JR Lee, JC Gowen, M Lark, MW Kumar, S
Citation: Am. Badger et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocytecultures, OSTEO CART, 8(6), 2000, pp. 434-443
Meniscal ossification in spontaneous osteoarthritis in the guinea-pig
Authors: Kapadia, RD Badger, AM Levin, JM Swift, B Bhattacharyya, A Dodds, RA Coatney, RW Lark, MW
Citation: Rd. Kapadia et al., Meniscal ossification in spontaneous osteoarthritis in the guinea-pig, OSTEO CART, 8(5), 2000, pp. 374-377
Preclinical development of keliximab, a Primatized (TM) anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model andsafety studies
Authors: Bugelski, PJ Herzyk, DJ Rehm, S Harmsen, AG Gore, EV Williams, DM Maleeff, BE Badger, AM Truneh, A O'Brien, SR Macia, RA Wier, PJ Morgan, DG Hart, TK
Citation: Pj. Bugelski et al., Preclinical development of keliximab, a Primatized (TM) anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model andsafety studies, HUM EXP TOX, 19(4), 2000, pp. 230-243
Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro
Authors: Nuttall, ME Nadeau, DP Fisher, PW Wang, F Keller, PM DeWolf, WE Goldring, MB Badger, AM Lee, D Levy, MA Gowen, M Lark, MW
Citation: Me. Nuttall et al., Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro, J ORTHOP R, 18(3), 2000, pp. 356-363
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality
Authors: Lee, D Long, SA Adams, JL Chan, G Vaidya, KS Francis, TA Kikly, K Winkler, JD Sung, CM Debouck, C Richardson, S Levy, MA DeWolf, WE Keller, PM Tomaszek, T Head, MS Ryan, MD Haltiwanger, RC Liang, PH Janson, CA McDevitt, PJ Johanson, K Concha, NO Chan, W Abdel-Meguid, SS Badger, AM Lark, MW Nadeau, DP Suva, LJ Gowen, M Nuttall, ME
Citation: D. Lee et al., Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality, J BIOL CHEM, 275(21), 2000, pp. 16007-16014
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
Authors: Badger, AM Griswold, DE Kapadia, R Blake, S Swift, BA Hoffman, SJ Stroup, GB Webb, E Rieman, DJ Gowen, M Boehm, JC Adams, JL Lee, JC
Citation: Am. Badger et al., Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis, ARTH RHEUM, 43(1), 2000, pp. 175-183
Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis
Authors: Loening, AM James, IE Levenston, ME Badger, AM Frank, EH Kurz, B Nuttall, ME Hung, HH Blake, SM Grodzinsky, AJ Lark, MW
Citation: Am. Loening et al., Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis, ARCH BIOCH, 381(2), 2000, pp. 205-212
Amphibian melanophore technology as a functional screen for antagonists ofG-protein coupled 7-transmembrane receptors
Authors: Nuttall, ME Lee, JC Murdock, PR Badger, AM Wang, FL Laydon, JT Hofmann, GA Pettman, GR Lee, JA Parihar, A van Wagenen, BC Fox, J Gowen, M Johnson, RK Mattern, MR
Citation: Me. Nuttall et al., Amphibian melanophore technology as a functional screen for antagonists ofG-protein coupled 7-transmembrane receptors, J BIOMOL SC, 4(5), 1999, pp. 269-277
Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration
Authors: Ragan, PM Badger, AM Cook, M Chin, VI Gowen, M Grodzinsky, AJ Lark, MW
Citation: Pm. Ragan et al., Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration, J ORTHOP R, 17(6), 1999, pp. 836-842
Atiprimod (SK & F106615), a novel macrophage targeting agent, enhances alveolar macrophage candidacidal activity and is not immunosuppressive in Candida-infected mice
Authors: Badger, AM Handler, JA Genell, CA Herzyk, D Gore, E Polsky, R Webb, L Bugelski, PJ
Citation: Am. Badger et al., Atiprimod (SK & F106615), a novel macrophage targeting agent, enhances alveolar macrophage candidacidal activity and is not immunosuppressive in Candida-infected mice, INT J IMMUN, 21(3), 1999, pp. 161-176
Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis
Authors: Badger, AM Blake, SM Dodds, RA Griswold, DE Swift, BA Rieman, DJ Stroup, GB Hoffman, SJ Gowen, M
Citation: Am. Badger et al., Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis, J PHARM EXP, 291(3), 1999, pp. 1380-1386
Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine
Authors: Badger, AM Cook, MN Swift, BA Newman-Tarr, TM Gowen, M Lark, M
Citation: Am. Badger et al., Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine, J PHARM EXP, 290(2), 1999, pp. 587-593
SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes (vol 161, pg 467, 1998)
Authors: Badger, AM Cook, MN Lark, MW Newman-Tarr, TM Swift, BA Nelson, AH Barone, FC Kumar, S
Citation: Am. Badger et al., SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes (vol 161, pg 467, 1998), J IMMUNOL, 162(5), 1999, pp. 3105-3105
Risultati: 1-20 |