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Results:
1-20
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Results: 20
Authors:
Kassahun, K
Pearson, PG
Tang, W
McIntosh, L
Leung, K
Elmore, C
Dean, D
Wang, R
Doss, G
Baillie, TA
Citation: K. Kassahun et al., Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission, CHEM RES T, 14(1), 2001, pp. 62-70
Authors:
Ngui, JS
Chen, Q
Shou, MG
Wang, RW
Stearns, RA
Baillie, TA
Tang, W
Citation: Js. Ngui et al., In vitro stimulation of warfarin metabolism by quinidine: Increases in theformation of 4 '- and 10-hydroxywarfarin, DRUG META D, 29(6), 2001, pp. 877-886
Authors:
Poon, GK
Chen, Q
Teffera, Y
Ngui, JS
Griffin, PR
Braun, MP
Doss, GA
Freeden, C
Stearns, RA
Evans, DC
Baillie, TA
Tang, W
Citation: Gk. Poon et al., Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans, DRUG META D, 29(12), 2001, pp. 1608-1613
Authors:
Baillie, TA
Halpin, RA
Matuszewski, BK
Geer, LA
Chavez-Eng, CM
Dean, D
Braun, M
Doss, G
Jones, A
Marks, T
Melillo, D
Vyas, KP
Citation: Ta. Baillie et al., Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: Evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques., DRUG META D, 29(12), 2001, pp. 1614-1628
Authors:
Lu, P
Lin, Y
Rodrigues, AD
Rushmore, TH
Baillie, TA
Shou, MG
Citation: P. Lu et al., Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-40trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4, DRUG META D, 29(11), 2001, pp. 1473-1479
Authors:
Shou, M
Dai, R
Cui, D
Korzekwa, KR
Baillie, TA
Rushmore, TH
Citation: M. Shou et al., A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4, J BIOL CHEM, 276(3), 2001, pp. 2256-2262
Authors:
Prueksaritanont, T
Lin, JH
Baillie, TA
Citation: T. Prueksaritanont et al., Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: linking in vitro with in vivo information - Reply, BR J CL PH, 49(1), 2000, pp. 89-90
Authors:
Ngui, JS
Tang, W
Stearns, RA
Shou, MG
Miller, RR
Zhang, Y
Lin, JH
Baillie, TA
Citation: Js. Ngui et al., Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine, DRUG META D, 28(9), 2000, pp. 1043-1050
Authors:
Zhang, KE
Kari, PH
Davis, MR
Doss, G
Baillie, TA
Vyas, KP
Citation: Ke. Zhang et al., Metabolism of a dopamine D-4-selective antagonist in rat, monkey, and humans: Formation of a novel mercapturic acid adduct, DRUG META D, 28(6), 2000, pp. 633-642
Authors:
Balani, SK
Xu, X
Arison, BH
Silva, MV
Gries, A
DeLuna, FA
Cui, DH
Kari, PH
Ly, T
Hop, CECA
Singh, R
Wallace, MA
Dean, DC
Lin, JH
Pearson, PG
Baillie, TA
Citation: Sk. Balani et al., Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine, DRUG META D, 28(11), 2000, pp. 1274-1278
Authors:
Baillie, TA
Pearson, PG
Citation: Ta. Baillie et Pg. Pearson, The impact of drug metabolism in contemporary drug discovery: New opportunities and challenges for mass spectrometry, MASS SPECTROMETRY IN BIOLOGY & MEDICINE, 2000, pp. 481-496
Authors:
Tang, W
Stearns, RA
Wang, RW
Chiu, SHL
Baillie, TA
Citation: W. Tang et al., Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac, CHEM RES T, 12(2), 1999, pp. 192-199
Authors:
Guan, XM
Davis, MR
Tang, CY
Jochheim, CM
Jin, LX
Baillie, TA
Citation: Xm. Guan et al., Identification of S-(n-butylcarbamoyl) glutathione, a reactive carbamoylating metabolite of tolbutamide in the rat, and evaluation of its inhibitory effects on glutathione reductase in vitro, CHEM RES T, 12(12), 1999, pp. 1138-1143
Authors:
Prueksaritanont, T
Ma, B
Tang, CY
Meng, Y
Assang, C
Lu, P
Reider, PJ
Lin, JH
Baillie, TA
Citation: T. Prueksaritanont et al., Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations, BR J CL PH, 47(3), 1999, pp. 291-298
Authors:
Shou, MG
Mei, Q
Ettore, MW
Dai, RK
Baillie, TA
Rushmore, TH
Citation: Mg. Shou et al., Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives, BIOCHEM J, 340, 1999, pp. 845-853
Authors:
Tang, W
Stearns, RA
Bandiera, SM
Zhang, Y
Raab, C
Braun, MP
Dean, DC
Pang, JM
Leung, KH
Doss, GA
Strauss, JR
Kwei, GY
Rushmore, TH
Chiu, SHL
Baillie, TA
Citation: W. Tang et al., Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: Identification of glutathione conjugated metabolites, DRUG META D, 27(3), 1999, pp. 365-372
Authors:
Fernandez-Metzler, CL
Owens, KG
Baillie, TA
King, RC
Citation: Cl. Fernandez-metzler et al., Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates, DRUG META D, 27(1), 1999, pp. 32-40
Authors:
Lin, JH
Chiba, M
Baillie, TA
Citation: Jh. Lin et al., Is the role of the small intestine in first-pass metabolism overemphasized?, PHARM REV, 51(2), 1999, pp. 135-157
Authors:
Tang, W
Stearns, RA
Kwei, GY
Iliff, SA
Miller, RR
Egan, MA
Yu, NX
Dean, DC
Kumar, S
Shou, MG
Lin, JH
Baillie, TA
Citation: W. Tang et al., Interaction of diclofenac and quinidine in monkeys: Stimulation of diclofenac metabolism, J PHARM EXP, 291(3), 1999, pp. 1068-1074
Authors:
Mei, Q
Tang, CY
Assang, C
Lin, Y
Slaughter, D
Rodrigues, AD
Baillie, TA
Rushmore, TH
Shou, MG
Citation: Q. Mei et al., Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 inassessment of human drug metabolism, J PHARM EXP, 291(2), 1999, pp. 749-759
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