Authors:
Bijsterbosch, MK
Ying, CX
De Vrueh, RLA
De Clercq, E
Biessen, EAL
Neyts, J
Van Berkel, TJC
Citation: Mk. Bijsterbosch et al., Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus, MOLEC PHARM, 60(3), 2001, pp. 521-527
Authors:
Bijsterbosch, MK
Manoharan, M
Dorland, R
Waarlo, IHE
Biessen, EAL
van Berkel, TJC
Citation: Mk. Bijsterbosch et al., Delivery of cholesteryl-conjugated phosphorothioate oligodeoxynucleotides to Kupffer cells by lactosylated low-density lipoprotein, BIOCH PHARM, 62(5), 2001, pp. 627-633
Authors:
Biessen, EAL
Valentijn, ARPM
De Vrueh, RLA
Van de Bilt, E
Sliedregt, LAJM
Prince, P
Bijsterbosch, MK
Van Boom, JH
Van der Marel, GA
Abrahams, PJ
Van Berkel, TJC
Citation: Eal. Biessen et al., Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity, FASEB J, 14(12), 2000, pp. 1784-1792
Authors:
Bijsterbosch, MK
Rump, ET
De Vrueh, RLA
Dorland, R
van Veghel, R
Tivel, KL
Biessen, EAL
van Berkel, TJC
Manoharan, M
Citation: Mk. Bijsterbosch et al., Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation, NUCL ACID R, 28(14), 2000, pp. 2717-2725
Authors:
de Vrueh, RLA
Rump, ET
van de Bilt, E
van Veghel, R
Balzarini, J
Biessen, EAL
van Berkel, TJC
Bijsterbosch, MK
Citation: Rla. De Vrueh et al., Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B, ANTIM AG CH, 44(3), 2000, pp. 477-483
Citation: Pac. 'T Hoen et al., Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes - Analysis with a novel reverse transcriptase-polymerase chain reaction assay, BIOCH PHARM, 60(10), 2000, pp. 1509-1518
Authors:
Rump, ET
de Vrueh, RLA
Manoharan, M
Waarlo, IHE
van Veghel, R
Biessen, EAL
van Berkel, TJC
Bijsterbosch, MK
Citation: Et. Rump et al., Modification of the plasma clearance and liver uptake of steroid ester-conjugated oligodeoxynucleotides by association with (lactosylated) low-density lipoprotein, BIOCH PHARM, 59(11), 2000, pp. 1407-1416
Authors:
de Vrueh, RLA
Rump, ET
Sliedregt, LAJM
Biessen, EAL
van Berkel, TJC
Bijsterbosch, MK
Citation: Rla. De Vrueh et al., Synthesis of a lipophilic prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its incorporation into a hepatocyte-specific lipidic carrier, PHARM RES, 16(8), 1999, pp. 1179-1185
Authors:
Versluis, AJ
Rump, ET
Rensen, PCN
Van Berkel, TJC
Bijsterbosch, MK
Citation: Aj. Versluis et al., Stable incorporation of a lipophilic daunorubicin prodrug into apolipoprotein E-exposing liposomes induces uptake of prodrug via low-density lipoprotein receptor in vivo, J PHARM EXP, 289(1), 1999, pp. 1-7
Authors:
Sliedregt, LAJM
Rensen, PCN
Rump, ET
van Santbrink, PJ
Bijsterbosch, MK
Valentijn, ARPM
van der Marel, GA
van Boom, JH
van Berkel, TJC
Biessen, EAL
Citation: Lajm. Sliedregt et al., Design and synthesis of novel amphiphilic dendritic galactosides for selective targeting of liposomes to the hepatic asialoglycoprotein receptor, J MED CHEM, 42(4), 1999, pp. 609-618
Authors:
Versluis, AJ
Rensen, PCN
Rump, ET
Van Berkel, TJC
Bijsterbosch, MK
Citation: Aj. Versluis et al., Low density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes, BR J CANC, 78(12), 1998, pp. 1607-1614