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Results: 1-25 | 26-45
Results: 1-25/45
N-(3-acyloxy-2-benzylpropyl)-N '-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands
Authors: Lee, J Lee, J Szabo, T Gonzalez, AF Welter, JD Blumberg, PM
Citation: J. Lee et al., N-(3-acyloxy-2-benzylpropyl)-N '-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands, BIO MED CH, 9(7), 2001, pp. 1713-1720
N-(3-acyloxy-2-benzylpropyl)-N '-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics
Authors: Lee, J Lee, J Kim, J Kim, SY Chun, MW Cho, HW Hwang, SW Oh, U Park, YH Marquez, VE Beheshti, M Szabo, T Blumberg, PM
Citation: J. Lee et al., N-(3-acyloxy-2-benzylpropyl)-N '-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics, BIO MED CH, 9(1), 2001, pp. 19-32
Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C
Authors: Ma, DW Zhang, T Wang, GQ Kozikowski, AP Lewin, NE Blumberg, PM
Citation: Dw. Ma et al., Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C, BIOORG MED, 11(2), 2001, pp. 99-101
Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation
Authors: Kuzhikandathil, EV Wang, HB Szabo, T Morozova, N Blumberg, PM Oxford, GS
Citation: Ev. Kuzhikandathil et al., Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation, J NEUROSC, 21(22), 2001, pp. 8697-8706
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to proteinkinase c (PK-C). Implications for isozyme specificity
Authors: Lee, J Han, KC Kang, JH Pearce, LL Lewin, NE Yan, SQ Benzaria, S Nicklaus, MC Blumberg, PM Marquez, VE
Citation: J. Lee et al., Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to proteinkinase c (PK-C). Implications for isozyme specificity, J MED CHEM, 44(25), 2001, pp. 4309-4312
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily
Authors: Shao, L Lewin, NE Lorenzo, PS Hu, ZJ Enyedy, IJ Garfield, SH Stone, JC Marner, FJ Blumberg, PM Wang, SM
Citation: L. Shao et al., Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily, J MED CHEM, 44(23), 2001, pp. 3872-3880
An optimized protein kinase C activating diacylglycerol combining high binding affinity (K-i) with reduced lipophilicity (log P)
Authors: Nacro, K Sigano, DM Yan, SQ Nicklaus, MC Pearce, LL Lewin, NE Garfield, SH Blumberg, PM Marquez, VE
Citation: K. Nacro et al., An optimized protein kinase C activating diacylglycerol combining high binding affinity (K-i) with reduced lipophilicity (log P), J MED CHEM, 44(12), 2001, pp. 1892-1904
Structural basis of binding of high-affinity ligands to protein kinase C: Prediction of the binding modes through a new molecular dynamics method andevaluation by site-directed mutagenesis
Authors: Pak, Y Enyedy, IJ Varady, J Kung, JW Lorenzo, PS Blumberg, PM Wang, SM
Citation: Y. Pak et al., Structural basis of binding of high-affinity ligands to protein kinase C: Prediction of the binding modes through a new molecular dynamics method andevaluation by site-directed mutagenesis, J MED CHEM, 44(11), 2001, pp. 1690-1701
Analysis of the native quaternary structure of vanilloid receptor 1
Authors: Kedei, N Szabo, T Lile, JD Treanor, JJ Olah, Z Iadarola, MJ Blumberg, PM
Citation: N. Kedei et al., Analysis of the native quaternary structure of vanilloid receptor 1, J BIOL CHEM, 276(30), 2001, pp. 28613-28619
Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions
Authors: Wang, QMJ Fang, TW Nacro, K Marquez, VE Wang, SM Blumberg, PM
Citation: Qmj. Wang et al., Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions, J BIOL CHEM, 276(22), 2001, pp. 19580-19587
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1
Authors: Olah, Z Szabo, T Karai, L Hough, C Fields, RD Caudle, RM Blumberg, PM Iadarola, MJ
Citation: Z. Olah et al., Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1, J BIOL CHEM, 276(14), 2001, pp. 11021-11030
Phorbol esters modulate the ras exchange factor RasGRP3
Authors: Lorenzo, PS Kung, JW Bottorff, DA Garfield, SH Stone, JC Blumberg, PM
Citation: Ps. Lorenzo et al., Phorbol esters modulate the ras exchange factor RasGRP3, CANCER RES, 61(3), 2001, pp. 943-949
Protein kinase C alpha and protein kinase C delta play opposite roles in the proliferation and apoptosis of glioma cells
Authors: Mandil, R Ashkenazi, E Blass, M Kronfeld, I Kazimirsky, G Rosenthal, G Umansky, F Lorenzo, PS Blumberg, PM Brodie, C
Citation: R. Mandil et al., Protein kinase C alpha and protein kinase C delta play opposite roles in the proliferation and apoptosis of glioma cells, CANCER RES, 61(11), 2001, pp. 4612-4619
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones
Authors: Nacro, K Bienfait, B Lewin, NE Blumberg, PM Marquez, VE
Citation: K. Nacro et al., Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones, BIOORG MED, 10(7), 2000, pp. 653-655
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones (vol 10, pg 653, 2000)
Authors: Nacro, K Bienfait, B Lewin, NE Blumberg, PM Marquez, VE
Citation: K. Nacro et al., Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones (vol 10, pg 653, 2000), BIOORG MED, 10(12), 2000, pp. 1401-1401
Effect of a tyrosine 155 to phenylalanine mutation of protein kinase C delta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts
Authors: Acs, P Beheshti, M Szallasi, Z Li, LW Yuspa, SH Blumberg, PM
Citation: P. Acs et al., Effect of a tyrosine 155 to phenylalanine mutation of protein kinase C delta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts, CARCINOGENE, 21(5), 2000, pp. 887-891
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
Authors: Mezey, E Toth, ZE Cortright, DN Arzubi, MK Krause, JE Elde, R Guo, A Blumberg, PM Szallasi, A
Citation: E. Mezey et al., Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human, P NAS US, 97(7), 2000, pp. 3655-3660
The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
Authors: Lorenzo, PS Beheshti, M Pettit, GR Stone, JC Blumberg, PM
Citation: Ps. Lorenzo et al., The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters, MOLEC PHARM, 57(5), 2000, pp. 840-846
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Authors: Nacro, K Bienfait, B Lee, J Han, KC Kang, JH Benzaria, S Lewin, NE Bhattacharyya, DK Blumberg, PM Marquez, VE
Citation: K. Nacro et al., Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?, J MED CHEM, 43(5), 2000, pp. 921-944
Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C
Authors: Tamamura, H Bienfait, B Nacro, K Lewin, NE Blumberg, PM Marquez, VE
Citation: H. Tamamura et al., Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C, J MED CHEM, 43(17), 2000, pp. 3209-3217
Phosphorylation of protein kinase C delta on distinct tyrosine residues regulates specific cellular functions
Authors: Kronfeld, I Kazimirsky, G Lorenzo, PS Garfield, SH Blumberg, PM Brodie, C
Citation: I. Kronfeld et al., Phosphorylation of protein kinase C delta on distinct tyrosine residues regulates specific cellular functions, J BIOL CHEM, 275(45), 2000, pp. 35491-35498
The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein
Authors: Wan, QJ Fang, TW Fenick, D Garfield, S Bienfait, B Marquez, VE Blumberg, PM
Citation: Qj. Wan et al., The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein, J BIOL CHEM, 275(16), 2000, pp. 12136-12146
RasGRP links T-cell receptor signaling to Ras
Authors: Ebinu, JO Stang, SL Teixeira, C Bottorff, DA Hooton, J Blumberg, PM Barry, M Bleakley, RC Ostergaard, HL Stone, JC
Citation: Jo. Ebinu et al., RasGRP links T-cell receptor signaling to Ras, BLOOD, 95(10), 2000, pp. 3199-3203
Inhibitors of protein kinase C and related receptors for the lipophilic second-messenger sn-1,2-diacylglycerol
Authors: Blumberg, PM Acs, P Bhattacharyya, DK Lorenzo, PS
Citation: Pm. Blumberg et al., Inhibitors of protein kinase C and related receptors for the lipophilic second-messenger sn-1,2-diacylglycerol, CANC DRUG, 5, 2000, pp. 347-364
Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells
Authors: Brodie, C Bogi, K Acs, P Lazarovici, P Petrovics, G Anderson, WB Blumberg, PM
Citation: C. Brodie et al., Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells, CELL GROWTH, 10(3), 1999, pp. 183-191
Risultati: 1-25 | 26-45