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Results: 1-25 | 26-28
Results: 1-25/28
3-PYRIDYLOXYPROPANOLAMINE AGONISTS OF THE BETA(3) ADRENERGIC-RECEPTORWITH IMPROVED PHARMACOKINETIC PROPERTIES
Authors: WEBER AE OK HO ALVARO RF CANDELORE MR CASCIERI MA CHIU SHL DENG LP FORREST MJ HOM GJ HUTCHINS JE KAO J MACINTYRE DE MATHVINK RJ MCLOUGHLIN D MILLER RR NEWBOLD RC OLAH TV PARMEE ER PERKINS L STEARNS RA STRADER CD SZUMILOSKI J TANG YS TOTA L VICARIO PP WYVRATT MJ FISHER MH
Citation: Ae. Weber et al., 3-PYRIDYLOXYPROPANOLAMINE AGONISTS OF THE BETA(3) ADRENERGIC-RECEPTORWITH IMPROVED PHARMACOKINETIC PROPERTIES, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2111-2116
SPECIES-DIFFERENCES IN N-GLUCURONIDATION
Authors: CHIU SHL HUSKEY SEW
Citation: Shl. Chiu et Sew. Huskey, SPECIES-DIFFERENCES IN N-GLUCURONIDATION, Drug metabolism and disposition, 26(9), 1998, pp. 838-847
DISPOSITION OF L-732,531, A POTENT IMMUNOSUPPRESSANT, IN RATS AND BABOONS
Authors: KARANAM BV MILLER RR COLLETTI A MONTGOMERY T CAREY KD HAWKINS T TANG YS LAVIN M STEARNS RA CHIU SHL VINCENT SH
Citation: Bv. Karanam et al., DISPOSITION OF L-732,531, A POTENT IMMUNOSUPPRESSANT, IN RATS AND BABOONS, Drug metabolism and disposition, 26(10), 1998, pp. 949-957
3-YL)PROPIONYL]-3-BENZYLPIPERIDINE-3(S)-CARBOXYLIC ACID ETHYL-ESTER (L-163,540) - A POTENT, ORALLY BIOAVAILABLE, AND SHORT-DURATION GROWTH-HORMONE SECRETAGOGUE
Authors: YANG LH MORRIELLO G PATCHETT AA LEUNG K JACKS T CHENG K SCHLEIM KD FEENEY W CHAN WWS CHIU SHL SMITH RG
Citation: Lh. Yang et al., 3-YL)PROPIONYL]-3-BENZYLPIPERIDINE-3(S)-CARBOXYLIC ACID ETHYL-ESTER (L-163,540) - A POTENT, ORALLY BIOAVAILABLE, AND SHORT-DURATION GROWTH-HORMONE SECRETAGOGUE, Journal of medicinal chemistry, 41(14), 1998, pp. 2439-2441
A POTENT, ORALLY BIOAVAILABLE BENZAZEPINONE GROWTH-HORMONE SECRETAGOGUE
Authors: DEVITA RJ BOCHIS R FRONTIER AJ KOTLIAR A FISHER MH SCHOEN WR WYVRATT MJ CHENG K CHAN WWS BUTLER B JACKS TM HICKEY GJ SCHLEIM KD LEUNG K CHEN ZS CHIU SHL FEENEY WP CUNNINGHAM PK SMITH RG
Citation: Rj. Devita et al., A POTENT, ORALLY BIOAVAILABLE BENZAZEPINONE GROWTH-HORMONE SECRETAGOGUE, Journal of medicinal chemistry, 41(10), 1998, pp. 1716-1728
A SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONIST INCREASES METABOLIC-RATE IN RHESUS-MONKEYS
Authors: FISHER MH AMEND AM BACH TJ BARKER JM BRADY EJ CANDELORE MR CARROLL D CASCIERI MA CHIU SHL DENG LP FORREST MJ HEGARTYFRISCINO B GUAN XM HOM GJ HUTCHINS JE KELLY LJ MATHVINK RJ METZGER JM MILLER RR OK HO PARMEE ER SAPERSTEIN R STRADER CD STEARNS RA THOMPSON GM TOTA L VICARIO PP WEBER AE WOODS JW WYVRATT MJ ZAFIAN PT MACINTYRE DE
Citation: Mh. Fisher et al., A SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONIST INCREASES METABOLIC-RATE IN RHESUS-MONKEYS, The Journal of clinical investigation, 101(11), 1998, pp. 2387-2393
THE DESIGN AND SYNTHESIS OF ORALLY-ACTIVE SHORT-DURATION SPIROINDANE GROWTH-HORMONE SECRETAGOGUES
Authors: TATA JR LU ZJ JACKS TM SCHLEIM KD CHENG K WEI LT CHAN WWS BUTLER B TSOU N LEUNG K CHIU SHL HICKEY G SMITH RG PATCHETT AA
Citation: Jr. Tata et al., THE DESIGN AND SYNTHESIS OF ORALLY-ACTIVE SHORT-DURATION SPIROINDANE GROWTH-HORMONE SECRETAGOGUES, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2319-2324
ORALLY-ACTIVE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .2. DISPOSITION OF L-694,458 IN RATS AND RHESUS-MONKEYS
Authors: VINCENT SH PAINTER SK LUFFERATLAS D KARANAM BV MCGOWAN E CIOFFE C DOSS G CHIU SHL
Citation: Sh. Vincent et al., ORALLY-ACTIVE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .2. DISPOSITION OF L-694,458 IN RATS AND RHESUS-MONKEYS, Drug metabolism and disposition, 25(8), 1997, pp. 932-939
ORALLY-ACTIVE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .3. IDENTIFICATION AND CHARACTERIZATION OF METABOLITES OF L-694,458 BY LIQUID-CHROMATOGRAPHY TANDEM MASS-SPECTROMETRY
Authors: LUFFERATLAS D VINCENT SH PAINTER SK ARISON BH STEARNS RA CHIU SHL
Citation: D. Lufferatlas et al., ORALLY-ACTIVE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .3. IDENTIFICATION AND CHARACTERIZATION OF METABOLITES OF L-694,458 BY LIQUID-CHROMATOGRAPHY TANDEM MASS-SPECTROMETRY, Drug metabolism and disposition, 25(8), 1997, pp. 940-952
PHARMACOKINETICS AND DISPOSITION OF THE OXYTOCIN RECEPTOR ANTAGONIST L-368,899 IN RATS AND DOGS
Authors: THOMPSON KL VINCENT SH MILLER RR COLLETTI AE ALVARO RF WALLACE MA FEENEY WP CHIU SHL
Citation: Kl. Thompson et al., PHARMACOKINETICS AND DISPOSITION OF THE OXYTOCIN RECEPTOR ANTAGONIST L-368,899 IN RATS AND DOGS, Drug metabolism and disposition, 25(10), 1997, pp. 1113-1118
DISPOSITION AND METABOLISM OF FINASTERIDE IN DOGS
Authors: CARLIN JR CHRISTOFALO P ARISON BH ELLSWORTH RE ROSEGAY A MILLER RR CHIU SHL VANDENHEUVEL WJA
Citation: Jr. Carlin et al., DISPOSITION AND METABOLISM OF FINASTERIDE IN DOGS, Drug metabolism and disposition, 25(1), 1997, pp. 100-109
PHARMACOKINETICS AND DISPOSITION OF L-692,429 - A NOVEL NONPEPTIDYL GROWTH-HORMONE SECRETAGOGUE IN PRECLINICAL SPECIES
Authors: LEUNG KH COHN DA MILLER RR DOSS GA STEARNS RA SIMPSON RE FEENEY WP CHIU SHL
Citation: Kh. Leung et al., PHARMACOKINETICS AND DISPOSITION OF L-692,429 - A NOVEL NONPEPTIDYL GROWTH-HORMONE SECRETAGOGUE IN PRECLINICAL SPECIES, Drug metabolism and disposition, 24(7), 1996, pp. 753-760
IDENTIFICATION OF HUMAN CYTOCHROME-P450 ISOZYMES RESPONSIBLE FOR THE IN-VITRO OXIDATIVE-METABOLISM OF FINASTERIDE (VOL 23, PG 1126, 1995)
Authors: HUSKEY SEW DEAN DC MILLER RR RASMUSSON GH CHIU SHL
Citation: Sew. Huskey et al., IDENTIFICATION OF HUMAN CYTOCHROME-P450 ISOZYMES RESPONSIBLE FOR THE IN-VITRO OXIDATIVE-METABOLISM OF FINASTERIDE (VOL 23, PG 1126, 1995), Drug metabolism and disposition, 24(6), 1996, pp. 695-695
ORALLY-ACTIVE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .1. DISPOSITION OF (L)-683,845 IN RATS AND RHESUS-MONKEYS
Authors: VINCENT SH PAINTER SK KRIETER PA COLLETTI AE LYSZACK E ROSEGAY A DEAN D LUFFERATLAS D MILLER RR CIOFFE C CHIU SHL
Citation: Sh. Vincent et al., ORALLY-ACTIVE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .1. DISPOSITION OF (L)-683,845 IN RATS AND RHESUS-MONKEYS, Drug metabolism and disposition, 24(12), 1996, pp. 1369-1377
ENTEROHEPATIC CIRCULATION OF THE ACIDIC PMN ELASTASE INHIBITOR L-683,845 IN MALE-RATS
Authors: COLLETTI AE KRIETER PA CHIU SHL
Citation: Ae. Colletti et al., ENTEROHEPATIC CIRCULATION OF THE ACIDIC PMN ELASTASE INHIBITOR L-683,845 IN MALE-RATS, The FASEB journal, 9(4), 1995, pp. 687-687
THE ROLE OF DRUG-METABOLISM IN DRUG DISCOVERY - A CASE-STUDY IN THE SELECTION OF AN OXYTOCIN RECEPTOR ANTAGONIST FOR DEVELOPMENT
Authors: CHIU SHL THOMPSON KA VINCENT SH ALVARO RF HUSKEY SEW STEARNS RA PETTIBONE DJ
Citation: Shl. Chiu et al., THE ROLE OF DRUG-METABOLISM IN DRUG DISCOVERY - A CASE-STUDY IN THE SELECTION OF AN OXYTOCIN RECEPTOR ANTAGONIST FOR DEVELOPMENT, Toxicologic pathology, 23(2), 1995, pp. 124-130
BIOTRANSFORMATION OF LOSARTAN TO ITS ACTIVE CARBOXYLIC-ACID METABOLITE IN HUMAN LIVER-MICROSOMES - ROLE OF CYTOCHROME P4502C AND 3A SUBFAMILY MEMBERS
Authors: STEARNS RA CHAKRAVARTY PK CHEN R CHIU SHL
Citation: Ra. Stearns et al., BIOTRANSFORMATION OF LOSARTAN TO ITS ACTIVE CARBOXYLIC-ACID METABOLITE IN HUMAN LIVER-MICROSOMES - ROLE OF CYTOCHROME P4502C AND 3A SUBFAMILY MEMBERS, Drug metabolism and disposition, 23(2), 1995, pp. 207-215
IDENTIFICATION OF HUMAN CYTOCHROME-P450 ISOZYMES RESPONSIBLE FOR THE IN-VITRO OXIDATIVE-METABOLISM OF FINASTERIDE
Authors: HUSKEY SEW DEAN DC MILLER RR RASMUSSON GH CHIU SHL
Citation: Sew. Huskey et al., IDENTIFICATION OF HUMAN CYTOCHROME-P450 ISOZYMES RESPONSIBLE FOR THE IN-VITRO OXIDATIVE-METABOLISM OF FINASTERIDE, Drug metabolism and disposition, 23(10), 1995, pp. 1126-1135
DESIGN AND BIOLOGICAL-ACTIVITIES OF L-163,191 (MK-0677) - A POTENT, ORALLY-ACTIVE GROWTH-HORMONE SECRETAGOGUE
Authors: PATCHETT AA NARGUND RP TATA JR CHEN MH BARAKAT KJ JOHNSTON DBR CHENG K CHAN WWS BUTLER B HICKEY G JACKS T SCHLEIM K PONG SS CHAUNG LYP CHEN HY FRAZIER E LEUNG KH CHIU SHL SMITH RG
Citation: Aa. Patchett et al., DESIGN AND BIOLOGICAL-ACTIVITIES OF L-163,191 (MK-0677) - A POTENT, ORALLY-ACTIVE GROWTH-HORMONE SECRETAGOGUE, Proceedings of the National Academy of Sciences of the United Statesof America, 92(15), 1995, pp. 7001-7005
MECHANISM OF BIOACTIVATION AND COVALENT BINDING OF 2,4,6-TRINITROTOLUENE
Authors: LEUNG KH YAO M STEARNS R CHIU SHL
Citation: Kh. Leung et al., MECHANISM OF BIOACTIVATION AND COVALENT BINDING OF 2,4,6-TRINITROTOLUENE, Chemico-biological interactions, 97(1), 1995, pp. 37-51
FK-506 METABOLISM IN HUMAN LIVER-MICROSOMES - INVESTIGATION OF THE INVOLVEMENT OF CYTOCHROME-P450 ISOZYMES OTHER THAN CYP3A4
Authors: KARANAM BV VINCENT SH CHIU SHL
Citation: Bv. Karanam et al., FK-506 METABOLISM IN HUMAN LIVER-MICROSOMES - INVESTIGATION OF THE INVOLVEMENT OF CYTOCHROME-P450 ISOZYMES OTHER THAN CYP3A4, Drug metabolism and disposition, 22(5), 1994, pp. 811-814
N-GLUCURONIDATION REACTIONS .2. RELATIVE N-GLUCURONIDATION REACTIVITYOF METHYLBIPHENYL TETRAZOLE, METHYLBIPHENYL TRIAZOLE, AND METHYLBIPHENYL IMIDAZOLE IN RAT, MONKEY, AND HUMAN HEPATIC MICROSOMES
Authors: HUSKEY SW DOSS GA MILLER RR SCHOEN WR CHIU SHL
Citation: Sw. Huskey et al., N-GLUCURONIDATION REACTIONS .2. RELATIVE N-GLUCURONIDATION REACTIVITYOF METHYLBIPHENYL TETRAZOLE, METHYLBIPHENYL TRIAZOLE, AND METHYLBIPHENYL IMIDAZOLE IN RAT, MONKEY, AND HUMAN HEPATIC MICROSOMES, Drug metabolism and disposition, 22(4), 1994, pp. 651-658
N-GLUCURONIDATION REACTIONS .3. REGIOSELECTIVITY OF N-GLUCURONIDATIONOF METHYLBIPHENYL TETRAZOLE, METHYLBIPHENYL TRIAZOLE, AND METHYLBIPHENYL IMIDAZOLE USING HUMAN AND RAT RECOMBINANT UDP-GLUCURONOSYLTRANSFERASES STABLY EXPRESSED IN V79 CELLS
Authors: HUSKEY SEW MAGDALOU J OUZZINE M SIEST G CHIU SHL
Citation: Sew. Huskey et al., N-GLUCURONIDATION REACTIONS .3. REGIOSELECTIVITY OF N-GLUCURONIDATIONOF METHYLBIPHENYL TETRAZOLE, METHYLBIPHENYL TRIAZOLE, AND METHYLBIPHENYL IMIDAZOLE USING HUMAN AND RAT RECOMBINANT UDP-GLUCURONOSYLTRANSFERASES STABLY EXPRESSED IN V79 CELLS, Drug metabolism and disposition, 22(4), 1994, pp. 659-662
)-YL)METHYL)SULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE (L-368,899) - AN ORALLY BIOAVAILABLE, NONPEPTIDE OXYTOCIN ANTAGONIST WITH POTENTIAL UTILITY FOR MANAGING PRETERM LABOR
Authors: WILLIAMS PD ANDERSON PS BALL RG BOCK MG CARROLL L CHIU SHL CLINESCHMIDT BV CULBERSON JC ERB JM EVANS BE FITZPATRICK SL FREIDINGER RM KAUFMAN MJ LUNDELL GF MURPHY JS PAWLUCZYK JM PERLOW DS PETTIBONE DJ PITZENBERGER SM THOMPSON KL VEBER DF
Citation: Pd. Williams et al., )-YL)METHYL)SULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE (L-368,899) - AN ORALLY BIOAVAILABLE, NONPEPTIDE OXYTOCIN ANTAGONIST WITH POTENTIAL UTILITY FOR MANAGING PRETERM LABOR, Journal of medicinal chemistry, 37(5), 1994, pp. 565-571
THE USE OF INVITRO METABOLISM STUDIES IN THE UNDERSTANDING OF NEW DRUGS
Authors: CHIU SHL
Citation: Shl. Chiu, THE USE OF INVITRO METABOLISM STUDIES IN THE UNDERSTANDING OF NEW DRUGS, Journal of pharmacological and toxicological methods, 29(2), 1993, pp. 77-83
Risultati: 1-25 | 26-28