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Results: 1-25 | 26-32
Results: 1-25/32
L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR
Authors: SANDERSON PEJ CUTRONA KJ DORSEY BD DYER DL MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ GARDELL SJ KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 817-822
C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION
Authors: ISAACS RCA CUTRONA KJ NEWTON CL SANDERSON PEJ SOLINSKY MG BASKIN EP CHEN IW COOPER CM COOK JJ GARDELL SJ LEWIS SD LUCAS RJ LYLE EA LYNCH JJ NAYLOROLSEN AM STRANIERI MT VASTAG K VACCA JP
Citation: Rca. Isaacs et al., C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1719-1724
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES
Authors: SANDERSON PEJ LYLE TA CUTRONA KJ DYER DL DORSEY BD MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ COOPER CM GARDELL SJ HARE TR KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K YAN YW SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES, Journal of medicinal chemistry, 41(23), 1998, pp. 4466-4474
DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION
Authors: TUCKER TJ BRADY SF LUMMA WC LEWIS SD GARDELL SJ NAYLOROLSEN AM YAN YW SISKO JT STAUFFER KJ LUCAS BJ LYNCH JJ COOK JJ STRANIERI MT HOLAHAN MA LYLE EA BASKIN EP CHEN IW DANCHECK KB KRUEGER JA COOPER CM VACCA JP
Citation: Tj. Tucker et al., DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION, Journal of medicinal chemistry, 41(17), 1998, pp. 3210-3219
RELATIONSHIP OF COLLATERAL VESSEL GROWTH AND RESERVE BLOOD-FLOW FOLLOWING HINDLIMB ISCHEMIA IN THE RABBIT
Authors: HERSHEY JC BASKIN EP GLASS JD HARTMAN HA COOK JJ
Citation: Jc. Hershey et al., RELATIONSHIP OF COLLATERAL VESSEL GROWTH AND RESERVE BLOOD-FLOW FOLLOWING HINDLIMB ISCHEMIA IN THE RABBIT, Circulation, 98(17), 1998, pp. 4160-4160
NONPEPTIDE GPIIB IIIA INHIBITORS .16. THIENO[2,3-B]THIOPHENE ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: PRUGH JD GOULD RJ LYNCH RJ ZHANG GX COOK JJ HOLAHAN MA STRANIERI MT SITKO GR GAUL SL BEDNAR RA BEDNAR B HARTMAN GD
Citation: Jd. Prugh et al., NONPEPTIDE GPIIB IIIA INHIBITORS .16. THIENO[2,3-B]THIOPHENE ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 865-870
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: BRASHEAR KM COOK JJ BEDNAR B BEDNAR RA GOULD RJ HALCZENKO W HOLAHAN MA LYNCH RJ HARTMAN GD HUTCHINSON JH
Citation: Km. Brashear et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2793-2798
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/
Authors: ASKEW BC MCINTYRE CJ HUNT CA CLAREMON DA BALDWIN JJ ANDERSON PS GOULD RJ LYNCH RJ CHANG CCT COOK JJ LYNCH JJ HOLAHAN MA SITKO GR STRANIERI MT
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1531-1536
ALLOSTERIC MODULATION OF RGD-BINDING SITES IN GP IIB IIIA BY THE ANTIBODY REOPRO(TM)/
Authors: BEDNAR RA CUNNINGHAM ME GAUL SL COOK JJ BEDNAR B GOULD RJ
Citation: Ra. Bednar et al., ALLOSTERIC MODULATION OF RGD-BINDING SITES IN GP IIB IIIA BY THE ANTIBODY REOPRO(TM)/, Thrombosis and haemostasis, 1997, pp. 2697-2697
EQUILIBRIUM AND DYNAMICS OF FIBRINOGEN RECEPTORS ON RESTING AND ACTIVATED PLATELETS AND IMPLICATIONS FOR THE SEPARATION OF EFFICACY AND BLEEDING-TIME
Authors: BEDNAR B BEDNAR RA MCQUENEY PA CUNNIGHAM ME EGBERTSON MS ASKEW BC COOK JJ HARTMAN GD GOULD RJ
Citation: B. Bednar et al., EQUILIBRIUM AND DYNAMICS OF FIBRINOGEN RECEPTORS ON RESTING AND ACTIVATED PLATELETS AND IMPLICATIONS FOR THE SEPARATION OF EFFICACY AND BLEEDING-TIME, Thrombosis and haemostasis, 1997, pp. 2757-2757
EFFECTS OF PENTOBARBITAL ON PHARMACOKINETICS AND PHARMACODYNAMICS OF A POTENT FIBRINOGEN RECEPTOR ANTAGONIST, L-734217, IN DOGS
Authors: PRUEKSARITANONT T STRANIERI MT HAND EL ELLIS JD HOLAHAN MA SITKO GR COOK JJ
Citation: T. Prueksaritanont et al., EFFECTS OF PENTOBARBITAL ON PHARMACOKINETICS AND PHARMACODYNAMICS OF A POTENT FIBRINOGEN RECEPTOR ANTAGONIST, L-734217, IN DOGS, Biopharmaceutics & drug disposition, 18(8), 1997, pp. 649-663
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/
Authors: COOK JJ SITKO GR HOLAHAN MA STRANIERI MT GLASS JD ASKEW BC MCINTYRE CJ CLAREMON DA BALDWIN JJ HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 677-689
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/
Authors: ASKEW BC BEDNAR RA BEDNAR B CLAREMON DA COOK JJ MCINTYRE CJ HUNT CA GOULD RJ LYNCH RJ LYNCH JJ GAUL SL STRANIERI MT SITKO GR HOLAHAN MA GLASS JD HAMILL T GORHAM LM PRUEKSARITANONT T BALDWIN JJ HARTMAN GD
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/, Journal of medicinal chemistry, 40(12), 1997, pp. 1779-1788
NONPEPTIDE GLYCOPROTEIN IIB LIIA INHIBITORS .14. ORAL ANTITHROMBOTIC EFFICACY OF L-738,167 IN A CONSCIOUS CANINE MODEL OF CORONARY-ARTERY ELECTROLYTIC INJURY/
Authors: COOK JJ GLASS JD SITKO GR HOLAHAN MA STUPIENSKI RF WALLACE AA STUMP GL HAND EL ASKEW BC HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB LIIA INHIBITORS .14. ORAL ANTITHROMBOTIC EFFICACY OF L-738,167 IN A CONSCIOUS CANINE MODEL OF CORONARY-ARTERY ELECTROLYTIC INJURY/, Circulation, 96(3), 1997, pp. 949-958
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .12. POTENT AND ORALLY-ACTIVE CENTRALLY CONSTRAINED THIENO[2,3-C]PYRIDONES/
Authors: HALCZENKO W COOK JJ HOLAHAN MA SITKO GR STRANIERI MT ZHANG GX LYNCH RJ LYNCH JJ GOULD RJ HARTMAN GD
Citation: W. Halczenko et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .12. POTENT AND ORALLY-ACTIVE CENTRALLY CONSTRAINED THIENO[2,3-C]PYRIDONES/, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2771-2776
NONPEPTIDE GPIIB IIIA INHIBITORS .10. CENTRALLY CONSTRAINED ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: EGBERTSON MS HARTMAN GD GOULD RJ BEDNAR B BEDNAR RA COOK JJ GAUL SL HOLAHAN MA LIBBY LA LYNCH JJ LYNCH RJ SITKO GR STRANIERI MT VASSALLO LM
Citation: Ms. Egbertson et al., NONPEPTIDE GPIIB IIIA INHIBITORS .10. CENTRALLY CONSTRAINED ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2519-2524
ANTITHROMBOTIC ACTIVITY OF RG13965, A NOVEL PLATELET FIBRINOGEN RECEPTOR ANTAGONIST
Authors: BOSTWICK JS KASIEWSKI CJ CHU V KLEIN SI SABATINO RD PERRONE MH DUNWIDDIE CT COOK JJ LEADLEY RJ
Citation: Js. Bostwick et al., ANTITHROMBOTIC ACTIVITY OF RG13965, A NOVEL PLATELET FIBRINOGEN RECEPTOR ANTAGONIST, Thrombosis research, 82(6), 1996, pp. 495-507
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/
Authors: COOK JJ HOLAHAN MA LYLE EA RAMJIT DR SITKO GR STRANIERI MT STUPIENSKI RF WALLACE AA HAND EL GEHRET JR KOTHSTEIN T DRAG MD MCCORMICK GY PERKINS JJ IHLE NC DUGGAN ME HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/, The Journal of pharmacology and experimental therapeutics, 278(1), 1996, pp. 62-73
NONPEPTIDE GLYCOPROTEIN IIB IIIA ANTAGONISTS .2. DESIGN AND IN-VIVO EVALUATION OF 3,4-DIHYDRO-1(1H)-ISOQUINOLINONE-BASED ANTAGONISTS AND ETHYL-ESTER PRODRUGS/
Authors: HUTCHINSON JH COOK JJ BRASHEAR KM BRESLIN MJ GLASS JD GOULD RJ HALCZENKO W HOLAHAN MA LYNCH RJ SITKO GR STRANIERI MT HARTMAN GD
Citation: Jh. Hutchinson et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA ANTAGONISTS .2. DESIGN AND IN-VIVO EVALUATION OF 3,4-DIHYDRO-1(1H)-ISOQUINOLINONE-BASED ANTAGONISTS AND ETHYL-ESTER PRODRUGS/, Journal of medicinal chemistry, 39(23), 1996, pp. 4583-4591
INVESTIGATION OF (OXODIOXOLENYL)METHYL CARBAMATES AS NONCHIRAL BIOREVERSIBLE PRODRUG MOIETIES FOR CHIRAL AMINES
Authors: ALEXANDER J BINDRA DS GLASS JD HOLAHAN MA RENYER ML RORK GS SITKO GR STRANIERI MT STUPIENSKI RF VEERAPANANE H COOK JJ
Citation: J. Alexander et al., INVESTIGATION OF (OXODIOXOLENYL)METHYL CARBAMATES AS NONCHIRAL BIOREVERSIBLE PRODRUG MOIETIES FOR CHIRAL AMINES, Journal of medicinal chemistry, 39(2), 1996, pp. 480-486
NOVEL MECHANISM FOR LONG-ACTING GPIIB IIIA ANTAGONISTS/
Authors: BEDNAR RA GAUL SL COOK JJ ASKEW BC HARTMAN GD GOULD RJ BEDNAR B
Citation: Ra. Bednar et al., NOVEL MECHANISM FOR LONG-ACTING GPIIB IIIA ANTAGONISTS/, Circulation, 94(8), 1996, pp. 568-568
DRUG-DEPENDENT ANTIBODIES AGAINST GPIIB IIIA INDUCE THROMBOCYTOPENIA/
Authors: BEDNAR B BEDNAR RA COOK JJ BOLLAG DM CHANG CT GAUL SL MCQUENEY PA EGBERTSON MS HARTMAN GD HOLAHAN MA LYNCH JJ GOULD RJ
Citation: B. Bednar et al., DRUG-DEPENDENT ANTIBODIES AGAINST GPIIB IIIA INDUCE THROMBOCYTOPENIA/, Circulation, 94(8), 1996, pp. 571-571
INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES
Authors: LEWIS SD NG AS LYLE EA MELLOTT MJ APPLEBY SD BRADY SF STAUFFER KJ SISKO JT MAO SS VEBER DF NUTT RF LYNCH JJ COOK JJ GARDELL SJ SHAFER JA
Citation: Sd. Lewis et al., INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES, Thrombosis and haemostasis, 74(4), 1995, pp. 1107-1112
CGCC REPOWERING NEARS COMMERCIAL STARTUP
Authors: COOK JJ LEDNICKY LA
Citation: Jj. Cook et La. Lednicky, CGCC REPOWERING NEARS COMMERCIAL STARTUP, Power engineering, 99(6), 1995, pp. 26-29
Risultati: 1-25 | 26-32