Citation: Hr. Costantino et al., WATER SORPTION BEHAVIOR OF LYOPHILIZED PROTEIN-SUGAR SYSTEMS AND IMPLICATIONS FOR SOLID-STATE INTERACTIONS, International journal of pharmaceutics, 166(2), 1998, pp. 211-221
Authors:
COSTANTINO HR
ANDYA JD
NGUYEN PA
DASOVICH N
SWEENEY TD
SHIRE SJ
HSU CC
MAA YF
Citation: Hr. Costantino et al., EFFECT OF MANNITOL CRYSTALLIZATION ON THE STABILITY AND AEROSOL PERFORMANCE OF A SPRAY-DRIED PHARMACEUTICAL PROTEIN, RECOMBINANT HUMANIZED ANTI-IGE MONOCLONAL-ANTIBODY, Journal of pharmaceutical sciences, 87(11), 1998, pp. 1406-1411
Authors:
COSTANTINO HR
CARRASQUILLO KG
CORDERO RA
MUMENTHALER M
HSU CC
GRIEBENOW K
Citation: Hr. Costantino et al., EFFECT OF EXCIPIENTS ON THE STABILITY AND STRUCTURE OF LYOPHILIZED RECOMBINANT HUMAN GROWTH-HORMONE, Journal of pharmaceutical sciences, 87(11), 1998, pp. 1412-1420
Authors:
COSTANTINO HR
SHIEH L
KLIBANOV AM
LANGER R
Citation: Hr. Costantino et al., HETEROGENEITY OF SERUM-ALBUMIN SAMPLES WITH RESPECT TO SOLID-STATE AGGREGATION VIA THIOL-DISULFIDE INTERCHANGE - IMPLICATIONS FOR SUSTAINED-RELEASE FROM POLYMERS, Journal of controlled release, 44(2-3), 1997, pp. 255-261
Authors:
OVERCASHIER DE
BROOKS DA
COSTANTINO HR
HSU CC
Citation: De. Overcashier et al., PREPARATION OF EXCIPIENT-FREE RECOMBINANT HUMAN TISSUE-TYPE PLASMINOGEN-ACTIVATOR BY LYOPHILIZATION FROM AMMONIUM BICARBONATE SOLUTION - ANINVESTIGATION OF THE 2-STAGE SUBLIMATION PHENOMENON (VOL 86, PG 455, 1997), Journal of pharmaceutical sciences, 86(7), 1997, pp. 880-880
Authors:
OVERCASHIER DE
BROOKS DA
COSTANTINO HR
HSU CC
Citation: De. Overcashier et al., PREPARATION OF EXCIPIENT-FREE RECOMBINANT HUMAN TISSUE-TYPE PLASMINOGEN-ACTIVATOR BY LYOPHILIZATION FROM AMMONIUM BICARBONATE SOLUTION - ANINVESTIGATION OF THE 2-STAGE SUBLIMATION PHENOMENON, Journal of pharmaceutical sciences, 86(4), 1997, pp. 455-459
Citation: Hr. Costantino et al., DETERMINING THE WATER SORPTION MONOLAYER OF LYOPHILIZED PHARMACEUTICAL PROTEINS, Journal of pharmaceutical sciences, 86(12), 1997, pp. 1390-1393
Authors:
COSTANTINO HR
GRIEBENOW K
LANGER R
KLIBANOV AM
Citation: Hr. Costantino et al., ON THE PH MEMORY OF LYOPHILIZED COMPOUNDS CONTAINING PROTEIN FUNCTIONAL-GROUPS, Biotechnology and bioengineering, 53(3), 1997, pp. 345-348
Authors:
LAM XM
COSTANTINO HR
OVERCASHIER DE
NGUYEN TH
HSU CC
Citation: Xm. Lam et al., REPLACING SUCCINATE WITH GLYCOLATE BUFFER IMPROVES THE STABILITY OF LYOPHILIZED INTERFERON-GAMMA, International journal of pharmaceutics, 142(1), 1996, pp. 85-95
Authors:
COSTANTINO HR
SCHWENDEMAN SP
GRIEBENOW K
KLIBANOV AM
LANGER R
Citation: Hr. Costantino et al., THE SECONDARY STRUCTURE AND AGGREGATION OF LYOPHILIZED TETANUS TOXOID, Journal of pharmaceutical sciences, 85(12), 1996, pp. 1290-1293
Citation: Hr. Costantino et al., AGGREGATION OF A LYOPHILIZED PHARMACEUTICAL PROTEIN, RECOMBINANT HUMAN ALBUMIN - EFFECT OF MOISTURE AND STABILIZATION BY EXCIPIENTS, Bio/technology, 13(5), 1995, pp. 493-496
Authors:
COSTANTINO HR
GRIEBENOW K
MISHRA P
LANGER R
KLIBANOV A
Citation: Hr. Costantino et al., FOURIER-TRANSFORM INFRARED SPECTROSCOPIC INVESTIGATION OF PROTEIN STABILITY IN THE LYOPHILIZED FORM, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1253(1), 1995, pp. 69-74
Authors:
SCHWENDEMAN SP
COSTANTINO HR
GUPTA RK
SIBER GR
KLIBANOV AM
LANGER R
Citation: Sp. Schwendeman et al., STABILIZATION OF TETANUS AND DIPHTHERIA TOXOIDS AGAINST MOISTURE-INDUCED AGGREGATION, Proceedings of the National Academy of Sciences of the United Statesof America, 92(24), 1995, pp. 11234-11238
Citation: Hr. Costantino et al., SOLID-PHASE AGGREGATION OF PROTEINS UNDER PHARMACEUTICALLY RELEVANT CONDITIONS, Journal of pharmaceutical sciences, 83(12), 1994, pp. 1662-1669