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Results: 1-25 | 26-34
Results: 1-25/34
Antibodies directed to drug epitopes to investigate the structure of drug-protein photoadducts. Recognition of a common photobound substructure in tiaprofenic acid/ketoprofen cross-photoreactivity
Authors: Lahoz, A Hernandez, D Miranda, MA Perez-Prieto, J Morera, IM Castell, JV
Citation: A. Lahoz et al., Antibodies directed to drug epitopes to investigate the structure of drug-protein photoadducts. Recognition of a common photobound substructure in tiaprofenic acid/ketoprofen cross-photoreactivity, CHEM RES T, 14(11), 2001, pp. 1486-1491
Mechanisms of drug photobinding to proteins: photobinding of suprofen to human serum albumin
Authors: Moser, J Hye, A Lovell, WW Earl, LK Castell, JV Miranda, MA
Citation: J. Moser et al., Mechanisms of drug photobinding to proteins: photobinding of suprofen to human serum albumin, TOX VITRO, 15(4-5), 2001, pp. 333-337
Biotransformation in vitro of the 22R and 22S epimers of budesonide by human liver, bronchus, colonic mucosa and skin
Authors: Cortijo, J Urbieta, E Bort, R Castell, JV Ruiz-Bravo, C Martinez, J Palacios-Pelaez, R Lledo, S Morcillo, EJ
Citation: J. Cortijo et al., Biotransformation in vitro of the 22R and 22S epimers of budesonide by human liver, bronchus, colonic mucosa and skin, FUN CL PHAR, 15(1), 2001, pp. 47-54
Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: A study using adenovirus-mediated antisense targeting
Authors: Jover, R Bort, R Gomez-Lechon, MJ Castell, JV
Citation: R. Jover et al., Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: A study using adenovirus-mediated antisense targeting, HEPATOLOGY, 33(3), 2001, pp. 668-675
The use of cultured hepatocytes to investigate the metabolism of drugs andmechanisms of drug hepatotoxicity
Authors: Gomez-Lechon, MJ Ponsoda, X Bort, R Castell, JV
Citation: Mj. Gomez-lechon et al., The use of cultured hepatocytes to investigate the metabolism of drugs andmechanisms of drug hepatotoxicity, ATLA-ALT L, 29(3), 2001, pp. 225-231
Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor
Authors: Ponsoda, X Pareja, E Gomez-Lechon, MJ Fabra, R Carrasco, E Trullenque, R Castell, JV
Citation: X. Ponsoda et al., Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor, J HEPATOL, 34(1), 2001, pp. 19-25
An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant
Authors: Andersson, TB Sjoberg, H Hoffmann, KJ Boobis, AR Watts, P Edwards, RJ Lake, BG Price, RJ Renwick, AB Gomez-Lechon, MJ Castell, JV Ingelman-Sundberg, M Hidestrand, M Goldfarb, PS Lewis, DFV Corcos, L Guillouzo, A Taavitsainen, P Pelkonen, O
Citation: Tb. Andersson et al., An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant, DRUG META D, 29(5), 2001, pp. 712-720
Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems
Authors: Pelkonen, O Myllynen, P Taavitsainen, P Boobis, AR Watts, P Lake, BG Price, RJ Renwick, AB Gomez-Lechon, MJ Castell, JV Ingelman-Sundberg, M Hidestrand, M Guillouzo, A Corcos, L Goldfarb, PS Lewis, DFV
Citation: O. Pelkonen et al., Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems, XENOBIOTICA, 31(6), 2001, pp. 321-343
Role of endogenous nitric oxide in liver-specific functions and survival of cultured rat hepatocytes
Authors: Donato, MT Ponsoda, X O'Connor, E Castell, JV Gomez-Lechon, MJ
Citation: Mt. Donato et al., Role of endogenous nitric oxide in liver-specific functions and survival of cultured rat hepatocytes, XENOBIOTICA, 31(5), 2001, pp. 249-264
Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2
Authors: Gomez-Lechon, MJ Donato, T Jover, R Rodriguez, C Ponsoda, X Glaise, D Castell, JV Guguen-Guillouzo, C
Citation: Mj. Gomez-lechon et al., Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2, EUR J BIOCH, 268(5), 2001, pp. 1448-1459
Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity
Authors: Rodriguez-Antona, C Donato, MT Pareja, E Gomez-Lechon, MJ Castell, JV
Citation: C. Rodriguez-antona et al., Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity, ARCH BIOCH, 393(2), 2001, pp. 308-315
Regio- and stereo-selectivity in the intramolecular quenching of the excited benzoylthiophene chromophore by tryptophan
Authors: Miranda, MA Lahoz, A Bosca, F Metni, MR Abdelouahab, FB Castell, JV Perez-Prieto, J
Citation: Ma. Miranda et al., Regio- and stereo-selectivity in the intramolecular quenching of the excited benzoylthiophene chromophore by tryptophan, CHEM COMMUN, (22), 2000, pp. 2257-2258
Photobinding of carprofen to protein
Authors: Moser, J Bosca, F Lovell, WW Castell, JV Miranda, MA Hye, A
Citation: J. Moser et al., Photobinding of carprofen to protein, J PHOTOCH B, 58(1), 2000, pp. 13-19
Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones
Authors: Ouedraogo, G Morliere, P Santus, R Miranda, MA Castell, JV
Citation: G. Ouedraogo et al., Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones, J PHOTOCH B, 58(1), 2000, pp. 20-25
Photoreactivity of tiaprofenic acid and suprofen using pig skin as an ex vivo model
Authors: Sarabia, Z Hernandez, D Castell, JV van Henegouwen, GMJB
Citation: Z. Sarabia et al., Photoreactivity of tiaprofenic acid and suprofen using pig skin as an ex vivo model, J PHOTOCH B, 58(1), 2000, pp. 32-36
Development of an expert system rulebase for the prospective identification of photoallergens
Authors: Barratt, MD Castell, JV Miranda, MA Langowski, JJ
Citation: Md. Barratt et al., Development of an expert system rulebase for the prospective identification of photoallergens, J PHOTOCH B, 58(1), 2000, pp. 54-61
In this special issue on the molecular and cellular mechanisms of drug phototoxicity
Authors: Gibbs, NK Castell, JV
Citation: Nk. Gibbs et Jv. Castell, In this special issue on the molecular and cellular mechanisms of drug phototoxicity, J PHOTOCH B, 58(1), 2000, pp. VII-VIII
New non-woven polyurethane-based biomaterials for the cultivation of hepatocytes: expression of differentiated functions
Authors: Gomez-Lechon, MJ Castell, JV Donato, T Pahernik, S Thasler, W Koebe, HG Doser, M Dauner, M Planck, H
Citation: Mj. Gomez-lechon et al., New non-woven polyurethane-based biomaterials for the cultivation of hepatocytes: expression of differentiated functions, J MAT S-M M, 11(1), 2000, pp. 37-41
The Second ECVAM Workshop on Phototoxicity Testing - The report and recommendations of ECVAM Workshop 42
Authors: Spielmann, H Muller, L Averbeck, D Balls, M Brendler-Schwaab, S Castell, JV Curren, R de Silva, O Gibbs, NK Liebsch, M Lovell, WW Merk, HF Nash, JF Neumann, NJ Pape, WJW Ulrich, P Vohr, HW
Citation: H. Spielmann et al., The Second ECVAM Workshop on Phototoxicity Testing - The report and recommendations of ECVAM Workshop 42, ATLA-ALT L, 28(6), 2000, pp. 777-814
Use of molecular topology in the selection of new cytostatic drugs
Authors: Galvez, J Garcia-Domenech, R Gomez-Lechon, MJ Castell, JV
Citation: J. Galvez et al., Use of molecular topology in the selection of new cytostatic drugs, J MOL ST-TH, 504, 2000, pp. 241-248
CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers
Authors: Donato, MT Viitala, P Rodriguez-Antona, C Lindfors, A Castell, JV Raunio, H Gomez-Lechon, MJ Pelkonen, O
Citation: Mt. Donato et al., CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers, DRUG META D, 28(11), 2000, pp. 1321-1326
In vitro identification of the cytochrome P450 isoform responsible for themetabolism of alpha-dihydroergocryptine
Authors: Althaus, M Retzow, A Castell, JV Gomez-Lechon, MJ Amalou, Z Rose, T Appel, K
Citation: M. Althaus et al., In vitro identification of the cytochrome P450 isoform responsible for themetabolism of alpha-dihydroergocryptine, XENOBIOTICA, 30(11), 2000, pp. 1033-1045
Tiaprofenic acid-photosensitized damage to nucleic acids: A mechanistic study using complementary in vitro approaches
Authors: Agapakis-Causse, C Bosca, F Castell, JV Hernandez, D Marin, ML Marrot, L Miranda, MA
Citation: C. Agapakis-causse et al., Tiaprofenic acid-photosensitized damage to nucleic acids: A mechanistic study using complementary in vitro approaches, PHOTOCHEM P, 71(5), 2000, pp. 499-505
Quantitative RT-PCR measurement of human cytochrome P-450s: Application todrug induction studies
Authors: Rodriguez-Antona, C Jover, R Gomez-Lechon, MJ Castell, JV
Citation: C. Rodriguez-antona et al., Quantitative RT-PCR measurement of human cytochrome P-450s: Application todrug induction studies, ARCH BIOCH, 376(1), 2000, pp. 109-116
Isolation of cross-coupling products in model studies on the photochemicalmodification of proteins by tiaprofenic acid
Authors: Miranda, MA Perez-Prieto, J Lahoz, A Morera, IM Sarabia, Z Martinez-Manez, R Castell, JV
Citation: Ma. Miranda et al., Isolation of cross-coupling products in model studies on the photochemicalmodification of proteins by tiaprofenic acid, EUR J ORG C, (2), 1999, pp. 497-502
Risultati: 1-25 | 26-34