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Results: 1-25/38
Authors:
Petit, A
Bihel, F
da Costa, CA
Pourquie, O
Checler, F
Kraus, JL
Citation: A. Petit et al., New protease inhibitors prevent gamma-secretase-mediated production of A beta 40/42 without affecting Notch cleavage, NAT CELL BI, 3(5), 2001, pp. 507-511
Authors:
Armogida, M
Petit, A
Vincent, B
Scarzello, S
da Costa, CA
Checler, F
Citation: M. Armogida et al., Endogenous beta-amyloid production in presenilin-deficient embryonic mousefibroblasts, NAT CELL BI, 3(11), 2001, pp. 1030-1033
Authors:
De Jonghe, C
Esselens, C
Kumar-Singh, S
Craessaerts, K
Serneels, S
Checler, F
Annaert, W
Van Broeckhoven, C
De Strooper, B
Citation: C. De Jonghe et al., Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability, HUM MOL GEN, 10(16), 2001, pp. 1665-1671
Authors:
Hasebe, T
Hua, J
Someya, A
Morain, P
Checler, F
Nagaoka, I
Citation: T. Hasebe et al., Involvement of cytosolic prolyl endopeptidase in degradation of p40-phox splice variant protein in myeloid cells, J LEUK BIOL, 69(6), 2001, pp. 963-968
Authors:
Dumanchin-Njock, C
da Costa, CA
Mercken, L
Pradier, L
Checler, F
Citation: C. Dumanchin-njock et al., The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells, J NEUROCHEM, 78(5), 2001, pp. 1153-1161
Authors:
Checler, F
Citation: F. Checler, The multiple paradoxes of presenilins, J NEUROCHEM, 76(6), 2001, pp. 1621-1627
Authors:
Lopez-Perez, E
Zhang, Y
Frank, SJ
Creemers, J
Seidah, N
Checler, F
Citation: E. Lopez-perez et al., Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10, J NEUROCHEM, 76(5), 2001, pp. 1532-1539
Authors:
Vincent, B
Paitel, E
Saftig, P
Frobert, Y
Hartmann, D
De Strooper, B
Grassi, J
Lopez-Perez, E
Checler, F
Citation: B. Vincent et al., The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein, J BIOL CHEM, 276(41), 2001, pp. 37743-37746
Authors:
Benjannet, S
Elagoz, A
Wickham, L
Mamarbachi, M
Munzer, JS
Basak, A
Lazure, C
Cromlish, JA
Sisodia, S
Checler, F
Chretien, M
Seidah, NG
Citation: S. Benjannet et al., Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding - The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production, J BIOL CHEM, 276(14), 2001, pp. 10879-10887
Authors:
Nunan, J
Shearman, MS
Checler, F
Cappai, R
Evin, G
Beyreuther, K
Masters, CL
Small, DH
Citation: J. Nunan et al., The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase, EUR J BIOCH, 268(20), 2001, pp. 5329-5336
Authors:
Mestre-Frances, N
Keller, E
Calenda, A
Barelli, H
Checler, F
Bons, N
Citation: N. Mestre-frances et al., Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate Microcebus murinus reveal distinct amyloid beta 1-42 and beta 1-40 immunoreactivity profiles, NEUROBIOL D, 7(1), 2000, pp. 1-8
Authors:
Kumar-Singh, S
Dewachter, I
Moechars, D
Lubke, U
De Jonghe, C
Ceuterick, C
Checler, F
Naidu, A
Cordell, B
Cras, P
Van Broeckhoven, C
Van Leuven, F
Citation: S. Kumar-singh et al., Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation, NEUROBIOL D, 7(1), 2000, pp. 9-22
Authors:
Checler, F
da Costa, CA
Ancolio, K
Chevallier, N
Lopez-Perez, E
Marambaud, P
Citation: F. Checler et al., Role of the proteasome in Alzheimer's disease, BBA-MOL BAS, 1502(1), 2000, pp. 133-138
Authors:
Colle, MA
Duyckaerts, C
Laquerriere, A
Pradier, L
Czech, C
Checler, F
Hauw, JJ
Citation: Ma. Colle et al., Laminar specific loss of isocortical presenilin 1 immunoreactivity in Alzheimer's disease. Correlations with the amyloid load and the density of tau-positive neurofibrillary tangles, NEUROP AP N, 26(2), 2000, pp. 117-123
Authors:
Ancolio, K
da Costa, CA
Ueda, K
Checler, F
Citation: K. Ancolio et al., alpha-Synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells, NEUROSCI L, 285(2), 2000, pp. 79-82
Authors:
Colle, MA
Hauw, JJ
Crespeau, F
Uchihara, T
Akiyama, H
Checler, F
Pageat, P
Duykaerts, C
Citation: Ma. Colle et al., Vascular and parenchymal A beta deposition in the aging dog: correlation with behavior, NEUROBIOL A, 21(5), 2000, pp. 695-704
Authors:
Amson, R
Lassalle, JM
Halley, H
Prieur, S
Lethrosne, F
Roperch, JP
Israeli, D
Gendron, MC
Duyckaerts, C
Checler, F
Dausset, J
Cohen, D
Oren, M
Telerman, A
Citation: R. Amson et al., Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice, P NAS US, 97(10), 2000, pp. 5346-5350
Authors:
Petanceska, SS
Seeger, M
Checler, F
Gandy, S
Citation: Ss. Petanceska et al., Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptideA beta 42 in late compartments of the constitutive secretory pathway, J NEUROCHEM, 74(5), 2000, pp. 1878-1884
Authors:
Vincent, B
Paitel, E
Frobert, Y
Lehmann, S
Grassi, J
Checler, F
Citation: B. Vincent et al., Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons, J BIOL CHEM, 275(45), 2000, pp. 35612-35616
Authors:
da Costa, CA
Ancolio, K
Checler, F
Citation: Ca. Da Costa et al., Wild-type but not Parkinson's disease-related Ala-53 -> Thr mutant alpha-synuclein protects neuronal cells from apoptotic stimuli, J BIOL CHEM, 275(31), 2000, pp. 24065-24069
Authors:
Petit, A
Barelli, H
Morain, P
Checler, F
Citation: A. Petit et al., Novel proline endopeptidase inhibitors do not modify A beta 40/42 formation and degradation by human cells expressing wild-type and Swedish mutated beta-amyloid precursor protein, BR J PHARM, 130(7), 2000, pp. 1613-1617
Authors:
Lopez-Perez, E
Dumanchin, C
Czech, C
Campion, D
Goud, B
Pradier, L
Frebourg, T
Checler, F
Citation: E. Lopez-perez et al., Overexpression of Rab11 or constitutively active Rab11 does not affect sAPP alpha and A beta secretions by wild-type and Swedish mutated beta APP-expressing HEK293 cells, BIOC BIOP R, 275(3), 2000, pp. 910-915
Authors:
Van Dorpe, J
Smeijers, L
Dewachter, I
Nuyens, D
Spittaels, K
Van den Haute, C
Mercken, M
Moechars, D
Laenen, I
Kuiperi, C
Bruynseels, K
Tesseur, I
Loos, R
Vanderstichele, H
Checler, F
Sciot, R
Van Leuven, F
Citation: J. Van Dorpe et al., Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons, AM J PATH, 157(4), 2000, pp. 1283-1298
Authors:
Gouras, GK
Tsai, J
Naslund, J
Vincent, B
Edgar, M
Checler, F
Greenfield, JP
Haroutunian, V
Buxbaum, JD
Xu, HX
Greengard, P
Relkin, NR
Citation: Gk. Gouras et al., Intraneuronal A beta 42 accumulation in human brain, AM J PATH, 156(1), 2000, pp. 15-20
Authors:
Checler, F
Citation: F. Checler, Presenilins: Multifunctional proteins involved in Alzheimer's disease pathology, IUBMB LIFE, 48(1), 1999, pp. 33-39