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Results: 1-7 |
Results: 7
The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: A binding mode for a structurally novel class of inhibitors
Authors: Chirgadze, NY Sall, DJ Briggs, SL Clawson, DK Zhang, M Smith, GF Schevitz, RW
Citation: Ny. Chirgadze et al., The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: A binding mode for a structurally novel class of inhibitors, PROTEIN SCI, 9(1), 2000, pp. 29-36
Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis
Authors: Chirgadze, NY Briggs, SL McAllister, KA Fischl, AS Zhao, GS
Citation: Ny. Chirgadze et al., Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis, EMBO J, 19(20), 2000, pp. 5281-5287
Structure-based design of potent, amidine-derived inhibitors of factor Xa:Evaluation of selectivity, anticoagulant activity, and antithrombotic activity
Authors: Wiley, MR Weir, LC Briggs, S Bryan, NA Buben, J Campbell, C Chirgadze, NY Conrad, RC Craft, TJ Ficorilli, JV Franciskovich, JB Froelich, LL Gifford-Moore, DS Goodson, T Herron, DK Klimkowski, VJ Kurz, KD Kyle, JA Masters, JJ Ratz, AM Milot, G Shuman, RT Smith, T Smith, GF Tebbe, AL Tinsley, JM Towner, RD Wilson, A Yee, YK
Citation: Mr. Wiley et al., Structure-based design of potent, amidine-derived inhibitors of factor Xa:Evaluation of selectivity, anticoagulant activity, and antithrombotic activity, J MED CHEM, 43(5), 2000, pp. 883-899
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives
Authors: Sall, DJ Bailey, DL Bastian, JA Buben, JA Chirgadze, NY Clemens-Smith, AC Denney, ML Fisher, MJ Giera, DD Gifford-Moore, DS Harper, RW Johnson, LM Klimkowski, VJ Kohn, TJ Lin, HS McCowan, JR Palkowitz, AD Richett, ME Smith, GF Snyder, DW Takeuchi, K Toth, JE Zhang, MS
Citation: Dj. Sall et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives, J MED CHEM, 43(4), 2000, pp. 649-663
Cry stal structure of human parathyroid hormone 1-34 at 0.9-angstrom resolution
Authors: Jin, L Briggs, SL Chandrasekhar, S Chirgadze, NY Clawson, DK Schevitz, RW Smiley, DL Tashjian, AH Zhang, FM
Citation: L. Jin et al., Cry stal structure of human parathyroid hormone 1-34 at 0.9-angstrom resolution, J BIOL CHEM, 275(35), 2000, pp. 27238-27244
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of invivo efficacy
Authors: Zhang, MS Bailey, DL Bastian, JA Briggs, SL Chirgadze, NY Clawson, DK Denney, ML Gifford-Moore, DS Harper, RW Johnson, LM Klimkowski, VJ Kohn, TJ Lin, HS McCowan, JR Richett, ME Sall, DJ Smith, AJ Smith, GF Snyder, DW Takeuchi, K Utterback, BG Yan, SCB
Citation: Ms. Zhang et al., Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of invivo efficacy, BIOORG MED, 9(5), 1999, pp. 775-780
The design of potent, selective, non-covalent, peptide thrombin inhibitorsutilizing imidazole as a S1 binding element
Authors: Wiley, MR Weir, LC Briggs, SI Chirgadze, NY Clawson, D Gifford-Moore, DS Schacht, AL Smith, GF Vasudevan, V Zornes, LL Klimkowski, VJ
Citation: Mr. Wiley et al., The design of potent, selective, non-covalent, peptide thrombin inhibitorsutilizing imidazole as a S1 binding element, BIOORG MED, 9(18), 1999, pp. 2767-2772
Risultati: 1-7 |