Authors:
Cleton, A
Altorf, BA
Voskuyl, RA
Danhof, M
Citation: A. Cleton et al., Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship, EUR J PH SC, 12(2), 2000, pp. 141-150
Authors:
Cleton, A
Odman, J
Van der Graaf, PH
Ghijsen, W
Voskuyl, R
Danhof, M
Citation: A. Cleton et al., Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam, PHARM RES, 17(3), 2000, pp. 321-327
Authors:
Cleton, A
Altorf, BA
Voskuyl, RA
Danhof, M
Citation: A. Cleton et al., Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels, BR J PHARM, 130(5), 2000, pp. 1037-1044
Authors:
Cleton, A
Van der Graaf, PH
Ghijsen, W
Voskuyl, R
Danhof, M
Citation: A. Cleton et al., Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy, PHARM RES, 16(11), 1999, pp. 1702-1709
Authors:
Cleton, A
de Greef, HJMM
Edelbroek, PM
Voskuyl, RA
Danhof, M
Citation: A. Cleton et al., Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat, J PHAR BIOP, 27(3), 1999, pp. 301-323
Authors:
Cleton, A
de Greef, HJMM
Edelbroek, PM
Voskuyl, RA
Danhof, M
Citation: A. Cleton et al., Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4,4-di-(3-methylthien-2-yl)but-3-enyl) nipecoticacid in the rat, BR J PHARM, 128(8), 1999, pp. 1651-1658
Citation: A. Cleton et al., Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats, BR J PHARM, 127(1), 1999, pp. 227-235