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Results: 1-25 | 26-29
Results: 1-25/29
Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase (vol 11, pg 2561, 2001)
Authors: Decicco, CP Nelson, DJ Luo, Y Shen, L Horiuchi, KY Amsler, KM Foster, LA Spitz, SM Merrill, JJ Sizemore, CF Rogers, KC Copeland, RA Harpel, MR
Citation: Cp. Decicco et al., Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase (vol 11, pg 2561, 2001), BIOORG MED, 11(23), 2001, pp. 3089-3089
Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase
Authors: Decicco, CP Nelson, DJ Luo, Y Shen, L Horiuchi, KY Amsler, KM Foster, LA Spitz, SM Merrill, JJ Sizemore, CF Rogers, KC Copeland, RA Harpel, MR
Citation: Cp. Decicco et al., Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase, BIOORG MED, 11(18), 2001, pp. 2561-2564
Characterization of recombinant, soluble beta-secretase from an insect cell expression system
Authors: Mallender, WD Yager, D Onstead, L Nichols, MR Eckman, C Sambamurti, K Kopcho, LM Marcinkeviciene, J Copeland, RA Rosenberry, TL
Citation: Wd. Mallender et al., Characterization of recombinant, soluble beta-secretase from an insect cell expression system, MOLEC PHARM, 59(3), 2001, pp. 619-626
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro andin vivo
Authors: Xue, CB Voss, ME Nelson, DJ Duan, JJW Cherney, RJ Jacobson, IC He, XH Roderick, J Chen, LH Corbett, RL Wang, L Meyer, DT Kennedy, K DeGrado, WF Hardman, KD Teleha, CA Jaffee, BD Liu, RQ Copeland, RA Covington, MB Christ, DD Trzaskos, JM Newton, RC Magolda, RL Wexler, RR Decicco, CP
Citation: Cb. Xue et al., Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro andin vivo, J MED CHEM, 44(16), 2001, pp. 2636-2660
Identification of the 3p pi(u)e(') (3)Delta(u) Rydberg state of O-2 by (3+1) resonance-enhanced multiphoton-ionization spectroscopy
Authors: Lewis, BR Gibson, ST Tucay, AA Robertson, R Hwang, ES Bergman, A Copeland, RA
Citation: Br. Lewis et al., Identification of the 3p pi(u)e(') (3)Delta(u) Rydberg state of O-2 by (3+1) resonance-enhanced multiphoton-ionization spectroscopy, J CHEM PHYS, 114(19), 2001, pp. 8364-8371
Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization
Authors: Lai, ZH Ferry, KV Diamond, MA Wee, KE Kim, YB Ma, JH Yang, T Benfield, PA Copeland, RA Auger, KR
Citation: Zh. Lai et al., Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization, J BIOL CHEM, 276(33), 2001, pp. 31357-31367
Mechanism of inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide
Authors: Marcinkeviciene, J Luo, Y Graciani, NR Combs, AP Copeland, RA
Citation: J. Marcinkeviciene et al., Mechanism of inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide, J BIOL CHEM, 276(26), 2001, pp. 23790-23794
Mechanistic studies of reaction coupling in Glu-tRNA(Gln) amidotransferase
Authors: Horiuchi, KY Harpel, MR Shen, L Luo, Y Rogers, KC Copeland, RA
Citation: Ky. Horiuchi et al., Mechanistic studies of reaction coupling in Glu-tRNA(Gln) amidotransferase, BIOCHEM, 40(21), 2001, pp. 6450-6457
Enoyl-ACP reductase (Fabl) of Haemophilus influenzae: Steady-state kineticmechanism and inhibition by triclosan and hexachlorophene
Authors: Marcinkeviciene, J Jiang, WJ Kopcho, LM Locke, G Luo, Y Copeland, RA
Citation: J. Marcinkeviciene et al., Enoyl-ACP reductase (Fabl) of Haemophilus influenzae: Steady-state kineticmechanism and inhibition by triclosan and hexachlorophene, ARCH BIOCH, 390(1), 2001, pp. 101-108
SCF beta-TRCP and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4
Authors: Strack, P Caligiuri, M Pelletier, M Boisclair, M Theodoras, A Beer-Romero, P Glass, S Parsons, T Copeland, RA Auger, KR Benfield, P Brizuela, L Rolfe, M
Citation: P. Strack et al., SCF beta-TRCP and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4, ONCOGENE, 19(31), 2000, pp. 3529-3536
Experimental investigation of surface reactions in carbon monoxide and oxygen mixtures
Authors: Sepka, S Chen, YK Marschall, J Copeland, RA
Citation: S. Sepka et al., Experimental investigation of surface reactions in carbon monoxide and oxygen mixtures, J THERMOPHY, 14(1), 2000, pp. 45-52
Steady-state kinetic analysis of human ubiquitin-activating enzyme (E1) using a fluorescently labeled ubiquitin substrate
Authors: Wee, KE Lai, ZH Auger, KR Ma, JH Horiuchi, KY Dowling, RL Dougherty, CS Corman, JI Wynn, R Copeland, RA
Citation: Ke. Wee et al., Steady-state kinetic analysis of human ubiquitin-activating enzyme (E1) using a fluorescently labeled ubiquitin substrate, J PROTEIN C, 19(6), 2000, pp. 489-498
Determination of serum protein binding affinity of inhibitors from analysis of concentration-response plots in biochemical activity assays
Authors: Copeland, RA
Citation: Ra. Copeland, Determination of serum protein binding affinity of inhibitors from analysis of concentration-response plots in biochemical activity assays, J PHARM SCI, 89(8), 2000, pp. 1000-1007
Presenilin-1 and-2 are molecular targets for gamma-secretase inhibitors
Authors: Seiffert, D Bradley, JD Rominger, CM Rominger, DH Yang, FD Meredith, JE Tang, Q Roach, AH Thompson, LA Spitz, SM Higaki, JN Prakash, SR Combs, AP Copeland, RA Arneric, SP Hartig, PR Robertson, DW Cordell, B Stern, AM Olson, RE Zaczek, R
Citation: D. Seiffert et al., Presenilin-1 and-2 are molecular targets for gamma-secretase inhibitors, J BIOL CHEM, 275(44), 2000, pp. 34086-34091
Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis
Authors: Copeland, RA Marcinkeviciene, J Haque, TS Kopcho, LM Jiang, WJ Wang, K Ecret, LD Sizemore, C Amsler, KA Foster, L Tadesse, S Combs, AP Stern, AM Trainor, GL Slee, A Rogers, MJ Hobbs, F
Citation: Ra. Copeland et al., Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis, J BIOL CHEM, 275(43), 2000, pp. 33373-33378
Role of Lys100 in human dihydroorotate dehydrogenase: Mutagenesis studies and chemical rescue by external amines
Authors: Jiang, WJ Locke, G Harpel, MR Copeland, RA Marcinkeviciene, J
Citation: Wj. Jiang et al., Role of Lys100 in human dihydroorotate dehydrogenase: Mutagenesis studies and chemical rescue by external amines, BIOCHEM, 39(27), 2000, pp. 7990-7997
Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones
Authors: Marcinkeviciene, J Rogers, MJ Kopcho, L Jiang, WJ Wang, K Murphy, DJ Lippy, J Link, S Chung, TDY Hobbs, F Haque, T Trainor, GL Slee, A Stern, AM Copeland, RA
Citation: J. Marcinkeviciene et al., Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones, BIOCH PHARM, 60(3), 2000, pp. 339-342
Thermodynamics of p53 binding to hdm2(1-126): Effects of phosphorylation and p53 peptide length
Authors: Lai, ZH Auger, KR Manubay, CM Copeland, RA
Citation: Zh. Lai et al., Thermodynamics of p53 binding to hdm2(1-126): Effects of phosphorylation and p53 peptide length, ARCH BIOCH, 381(2), 2000, pp. 278-284
A second dihydroorotate dehydrogenase (type A) of the human pathogen Enterococcus faecalis: Expression, purification, and steady-state kinetic mechanism
Authors: Marcinkeviciene, J Jiang, WJ Locke, G Kopcho, LM Rogers, MJ Copeland, RA
Citation: J. Marcinkeviciene et al., A second dihydroorotate dehydrogenase (type A) of the human pathogen Enterococcus faecalis: Expression, purification, and steady-state kinetic mechanism, ARCH BIOCH, 377(1), 2000, pp. 178-186
Implementation of a continuous, enzyme-coupled fluorescence assay for high-throughput analysis of glutamate-producing enzymes
Authors: McElroy, KE Bouchard, PJ Harpel, MR Horiuchi, KY Rogers, KC Murphy, DJ Chung, TDY Copeland, RA
Citation: Ke. Mcelroy et al., Implementation of a continuous, enzyme-coupled fluorescence assay for high-throughput analysis of glutamate-producing enzymes, ANALYT BIOC, 284(2), 2000, pp. 382-387
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production
Authors: Cherney, RJ Wang, L Meyer, DT Xue, CB Arner, EC Copeland, RA Covington, MB Hardman, KD Wasserman, ZR Jaffee, BD Decicco, CP
Citation: Rj. Cherney et al., Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production, BIOORG MED, 9(9), 1999, pp. 1279-1284
Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the centralring and o-biphenyl analogs
Authors: Pinto, DJP Batt, DG Pitts, WJ Petraitis, JJ Orwat, MJ Wang, SG Jetter, JW Sherk, SR Houghton, GC Copeland, RA Covington, MB Trzaskos, JM Magolda, RL
Citation: Djp. Pinto et al., Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the centralring and o-biphenyl analogs, BIOORG MED, 9(7), 1999, pp. 919-924
Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins
Authors: Tortorella, MD Burn, TC Pratta, MA Abbaszade, I Hollis, JM Liu, R Rosenfeld, SA Copeland, RA Decicco, CP Wynn, R Rockwell, A Yang, F Duke, JL Solomon, K George, H Bruckner, R Nagase, H Itoh, Y Ellis, DM Ross, H Wiswall, BH Murphy, K Hillman, MC Hollis, GF Newton, RC Magolda, RL Trzaskos, JM Arner, EC
Citation: Md. Tortorella et al., Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins, SCIENCE, 284(5420), 1999, pp. 1664-1666
Missing bands in the multiphoton excitation of coupled molecular states
Authors: Lewis, BR Gibson, ST Copeland, RA Bressler, CG
Citation: Br. Lewis et al., Missing bands in the multiphoton excitation of coupled molecular states, PHYS REV L, 82(21), 1999, pp. 4212-4215
Temperature dependence of the collisional removal of O-2(b (1)Sigma(+)(g),v = 1 and 2) at 110-260 K, and atmospheric applications
Authors: Hwang, ES Bergman, A Copeland, RA Slanger, TG
Citation: Es. Hwang et al., Temperature dependence of the collisional removal of O-2(b (1)Sigma(+)(g),v = 1 and 2) at 110-260 K, and atmospheric applications, J CHEM PHYS, 110(1), 1999, pp. 18-24
Risultati: 1-25 | 26-29