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COMPARATIVE MUTATIONAL SPECTRA OF THE NITROGEN-MUSTARD CHLORAMBUCIL AND ITS HALF-MUSTARD ANALOG IN CHINESE-HAMSTER AS52 CELLS
Authors: YAGHI BM TURNER PM DENNY WA TURNER PR OCONNOR CJ FERGUSON LR
Citation: Bm. Yaghi et al., COMPARATIVE MUTATIONAL SPECTRA OF THE NITROGEN-MUSTARD CHLORAMBUCIL AND ITS HALF-MUSTARD ANALOG IN CHINESE-HAMSTER AS52 CELLS, Mutation research. Fundamental and molecular mechanisms of mutagenesis, 401(1-2), 1998, pp. 153-164
GENE-DIRECTED ENZYME PRODRUG THERAPY - QUANTITATIVE BYSTANDER CYTOTOXICITY AND DNA-DAMAGE INDUCED BY CB1954 IN CELLS EXPRESSING BACTERIAL NITROREDUCTASE
Authors: FRIEDLOS F COURT S FORD M DENNY WA SPRINGER C
Citation: F. Friedlos et al., GENE-DIRECTED ENZYME PRODRUG THERAPY - QUANTITATIVE BYSTANDER CYTOTOXICITY AND DNA-DAMAGE INDUCED BY CB1954 IN CELLS EXPRESSING BACTERIAL NITROREDUCTASE, Gene therapy, 5(1), 1998, pp. 105-112
SYNTHESIS AND HYPOXIA-SELECTIVE CYTOTOXICITY OF A 2-NITROIMIDAZOLE MUSTARD
Authors: LEE HH PALMER BD WILSON WR DENNY WA
Citation: Hh. Lee et al., SYNTHESIS AND HYPOXIA-SELECTIVE CYTOTOXICITY OF A 2-NITROIMIDAZOLE MUSTARD, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1741-1744
INHIBITION OF GROWTH OF PRIMARY HUMAN TUMOR-CELL CULTURES BY A 4-ANILINOQUINAZOLINE INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR FAMILY OF TYROSINE KINASES
Authors: BAGULEY BC MARSHALL ES HOLDAWAY IM REWCASTLE GW DENNY WA
Citation: Bc. Baguley et al., INHIBITION OF GROWTH OF PRIMARY HUMAN TUMOR-CELL CULTURES BY A 4-ANILINOQUINAZOLINE INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR FAMILY OF TYROSINE KINASES, European journal of cancer, 34(7), 1998, pp. 1086-1090
INHIBITION OF RNA-SYNTHESIS IN-VITRO BY ACRIDINES - RELATION BETWEEN STRUCTURE AND ACTIVITY
Authors: PIESTRZENIEWICZ MK WILMANSKA D STUDZIAN K SZEMRAJ J CZYZ M DENNY WA GNIAZDOWSKI M
Citation: Mk. Piestrzeniewicz et al., INHIBITION OF RNA-SYNTHESIS IN-VITRO BY ACRIDINES - RELATION BETWEEN STRUCTURE AND ACTIVITY, Zeitschrift fur Naturforschung. C, A journal of biosciences, 53(5-6), 1998, pp. 359-368
DEVELOPMENT OF IRREVERSIBLE EGFR TYROSINE KINASE INHIBITORS WITH ANTITUMOR-ACTIVITY AGAINST HUMAN TUMOR XENOGRAFTS
Authors: SMAILL JB DENNY WA FRY DW NELSON JM LEOPOLD WR VINCENT PW HOOK KE ELLIOTT WL BRIDGES AJ ZHOU H SHOWALTER HDH MCNAMARA DJ DOBRUSIN EM
Citation: Jb. Smaill et al., DEVELOPMENT OF IRREVERSIBLE EGFR TYROSINE KINASE INHIBITORS WITH ANTITUMOR-ACTIVITY AGAINST HUMAN TUMOR XENOGRAFTS, Annals of oncology, 9, 1998, pp. 415-415
SYNTHESIS OF NITROGEN AND SULFUR ANALOGS OF THE SECO-CI ALKYLATING AGENT
Authors: TERCEL M DENNY WA
Citation: M. Tercel et Wa. Denny, SYNTHESIS OF NITROGEN AND SULFUR ANALOGS OF THE SECO-CI ALKYLATING AGENT, Journal of the Chemical Society. Perkin transactions. I, (3), 1998, pp. 509-519
MONOFUNCTIONAL AND DIFUNCTIONAL NITROGEN-MUSTARD ANALOGS OF THE DNA MINOR-GROOVE BINDER PIBENZIMOL - SYNTHESIS, CYTOTOXICITY AND INTERACTION WITH DNA
Authors: SMAILL JB FAN JY PAPA PV OCONNOR CJ DENNY WA
Citation: Jb. Smaill et al., MONOFUNCTIONAL AND DIFUNCTIONAL NITROGEN-MUSTARD ANALOGS OF THE DNA MINOR-GROOVE BINDER PIBENZIMOL - SYNTHESIS, CYTOTOXICITY AND INTERACTION WITH DNA, Anti-cancer drug design, 13(3), 1998, pp. 221-242
BIS(DIALKYL)DITHIOCARBAMATO COBALT(III) COMPLEXES OF BIDENTATE NITROGEN MUSTARDS - SYNTHESIS, REDUCTION CHEMISTRY AND BIOLOGICAL EVALUATIONAS HYPOXIA-SELECTIVE CYTOTOXINS
Authors: WARE DC PALMER HR PRUIJN FB ANDERSON RE BROTHERS PJ DENNY WA WILSON WR
Citation: Dc. Ware et al., BIS(DIALKYL)DITHIOCARBAMATO COBALT(III) COMPLEXES OF BIDENTATE NITROGEN MUSTARDS - SYNTHESIS, REDUCTION CHEMISTRY AND BIOLOGICAL EVALUATIONAS HYPOXIA-SELECTIVE CYTOTOXINS, Anti-cancer drug design, 13(2), 1998, pp. 81-103
NITROGEN, SULFUR AND OXYGEN DONOR ADDUCTS WITH COPPER(II) COMPLEXES OF ANTITUMOR 2-FORMYLPYRIDINETHIOSEMICARBAZONE ANALOGS - PHYSICOCHEMICAL AND CYTOTOXIC STUDIES
Authors: AINSCOUGH EW BRODIE AM DENNY WA FINLAY GJ RANFORD RD
Citation: Ew. Ainscough et al., NITROGEN, SULFUR AND OXYGEN DONOR ADDUCTS WITH COPPER(II) COMPLEXES OF ANTITUMOR 2-FORMYLPYRIDINETHIOSEMICARBAZONE ANALOGS - PHYSICOCHEMICAL AND CYTOTOXIC STUDIES, Journal of inorganic biochemistry, 70(3-4), 1998, pp. 175-185
AN EFFICIENT LARGE-SCALE SYNTHESIS OF 2-METHOXYTETRAHYDROPHENANTHRIDINE
Authors: HAY MP DENNY WA
Citation: Mp. Hay et Wa. Denny, AN EFFICIENT LARGE-SCALE SYNTHESIS OF 2-METHOXYTETRAHYDROPHENANTHRIDINE, Synthetic communications, 28(3), 1998, pp. 463-470
REDUCTION OF NITROARYLMETHYL QUATERNARY AMMONIUM PRODRUGS OF MECHLORETHAMINE BY RADIATION
Authors: WILSON WR FERRY DM TERCEL M ANDERSON RF DENNY WA
Citation: Wr. Wilson et al., REDUCTION OF NITROARYLMETHYL QUATERNARY AMMONIUM PRODRUGS OF MECHLORETHAMINE BY RADIATION, Radiation research, 149(3), 1998, pp. 237-245
SPECIFIC, IRREVERSIBLE INACTIVATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND ERBB2, BY A NEW CLASS OF TYROSINE KINASE INHIBITOR
Authors: FRY DW BRIDGES AJ DENNY WA DOHERTY A GREIS KD HICKS JL HOOK KE KELLER PR LEOPOLD WR LOO JA MCNAMARA DJ NELSON JM SHERWOOD V SMAILL JB TRUMPPKALLMEYER S DOBRUSIN EM
Citation: Dw. Fry et al., SPECIFIC, IRREVERSIBLE INACTIVATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND ERBB2, BY A NEW CLASS OF TYROSINE KINASE INHIBITOR, Proceedings of the National Academy of Sciences of the United Statesof America, 95(20), 1998, pp. 12022-12027
TYROSINE KINASE INHIBITORS - 14 - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR METHYLAMINO-SUBSTITUTED DERIVATIVES OF ENYL)AMINO]-6-(METHYLAMINO)PYRIDO[3,4-D]PYRIMIDINE (PD-158780), A POTENT AND SPECIFIC INHIBITOR OF THE TYROSINE KINASE-ACTIVITY OF RECEPTORS FOR THE EGF FAMILY OF GROWTH-FACTORS
Authors: REWCASTLE GW MURRAY DK ELLIOTT WL FRY DW HOWARD CT NELSON JM ROBERTS BJ VINCENT PW SHOWALTER HDH WINTERS RT DENNY WA
Citation: Gw. Rewcastle et al., TYROSINE KINASE INHIBITORS - 14 - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR METHYLAMINO-SUBSTITUTED DERIVATIVES OF ENYL)AMINO]-6-(METHYLAMINO)PYRIDO[3,4-D]PYRIMIDINE (PD-158780), A POTENT AND SPECIFIC INHIBITOR OF THE TYROSINE KINASE-ACTIVITY OF RECEPTORS FOR THE EGF FAMILY OF GROWTH-FACTORS, Journal of medicinal chemistry, 41(5), 1998, pp. 742-751
DNA-DIRECTED ALKYLATING-AGENTS - 7 - SYNTHESIS, DNA INTERACTION, AND ANTITUMOR-ACTIVITY OF BIS(HYDROXYMETHYL)-SUBSTITUTED AND BIS(CARBAMATE)-SUBSTITUTED PYRROLIZINES AND IMIDAZOLES
Authors: ATWELL GJ FAN JY TAN K DENNY WA
Citation: Gj. Atwell et al., DNA-DIRECTED ALKYLATING-AGENTS - 7 - SYNTHESIS, DNA INTERACTION, AND ANTITUMOR-ACTIVITY OF BIS(HYDROXYMETHYL)-SUBSTITUTED AND BIS(CARBAMATE)-SUBSTITUTED PYRROLIZINES AND IMIDAZOLES, Journal of medicinal chemistry, 41(24), 1998, pp. 4744-4754
DEVELOPMENT, STRUCTURE-ACTIVITY-RELATIONSHIPS AND ANTITUMOR-ACTIVITY OF A NOVEL CLASS OF SPECIFIC, IRREVERSIBLE EGFR TK INHIBITORS
Authors: SMAILL JB DENNY WA FRY DW NELSON JM LEOPOLD WR VINCENT PW PATMORE SJ ELLIOTT WL HOOK KE BRIDGES AJ ZHOU H SHOWALTER HDH MCNAMARA DJ DOBRUSIN EM
Citation: Jb. Smaill et al., DEVELOPMENT, STRUCTURE-ACTIVITY-RELATIONSHIPS AND ANTITUMOR-ACTIVITY OF A NOVEL CLASS OF SPECIFIC, IRREVERSIBLE EGFR TK INHIBITORS, British Journal of Cancer, 78, 1998, pp. 34-34
CYTOTOXIC AND DNA-DAMAGING PROPERTIES OF N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE (DACA) AND ITS ANALOGS
Authors: PASTWA E CIESIELSKA E PIESTRZENIEWICZ MK DENNY WA GNIAZDOWSKI M SZMIGIERO L
Citation: E. Pastwa et al., CYTOTOXIC AND DNA-DAMAGING PROPERTIES OF N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE (DACA) AND ITS ANALOGS, Biochemical pharmacology, 56(3), 1998, pp. 351-359
PULSE-RADIOLYSIS STUDIES ON THE FRAGMENTATION OF ARYLMETHYL QUATERNARY NITROGEN MUSTARDS BY ONE-ELECTRON REDUCTION IN AQUEOUS-SOLUTION
Authors: ANDERSON RF DENNY WA LI WJ PACKER JE TERCEL M WILSON WR
Citation: Rf. Anderson et al., PULSE-RADIOLYSIS STUDIES ON THE FRAGMENTATION OF ARYLMETHYL QUATERNARY NITROGEN MUSTARDS BY ONE-ELECTRON REDUCTION IN AQUEOUS-SOLUTION, The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 101(50), 1997, pp. 9704-9709
C-11 LABELING OF THE ANTITUMOR AGENT N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE (DACA) AND DETERMINATION OF PLASMA METABOLITES IN MAN
Authors: BRADY F LUTHRA SK BROWN G OSMAN S HARTE RJA DENNY WA BAGULEY BC JONES T PRICE PM
Citation: F. Brady et al., C-11 LABELING OF THE ANTITUMOR AGENT N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE (DACA) AND DETERMINATION OF PLASMA METABOLITES IN MAN, Applied radiation and isotopes, 48(4), 1997, pp. 487-492
NITRO REDUCTION AS AN ELECTRONIC SWITCH FOR BIOREDUCTIVE DRUG ACTIVATION
Authors: SIIM BG DENNY WA WILSON WR
Citation: Bg. Siim et al., NITRO REDUCTION AS AN ELECTRONIC SWITCH FOR BIOREDUCTIVE DRUG ACTIVATION, Oncology research, 9(6-7), 1997, pp. 357-369
SYNTHESIS AND CYTOTOXICITY OF AMINO ANALOGS OF THE POTENT DNA ALKYLATING AGENT SECO-CBI-TMI
Authors: ATWELL GJ WILSON WR DENNY WA
Citation: Gj. Atwell et al., SYNTHESIS AND CYTOTOXICITY OF AMINO ANALOGS OF THE POTENT DNA ALKYLATING AGENT SECO-CBI-TMI, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1493-1496
MINOR-GROOVE BINDING OF A BIS-QUATERNARY AMMONIUM COMPOUND - THE CRYSTAL-STRUCTURE OF SN-7167 BOUND TO D(CGCGAATTCGCG)(2)
Authors: SQUIRE CJ CLARK GR DENNY WA
Citation: Cj. Squire et al., MINOR-GROOVE BINDING OF A BIS-QUATERNARY AMMONIUM COMPOUND - THE CRYSTAL-STRUCTURE OF SN-7167 BOUND TO D(CGCGAATTCGCG)(2), Nucleic acids research, 25(20), 1997, pp. 4072-4078
PROTEIN-DNA INTERACTIONS IN THE HUMAN BETA-GLOBIN - LOCUS-CONTROL REGION HYPERSENSITIVE SITE-2 AS REVEALED BY 4 NITROGEN MUSTARDS
Authors: TEMPLE MD CAIRNS MJ DENNY WA MURRAY V
Citation: Md. Temple et al., PROTEIN-DNA INTERACTIONS IN THE HUMAN BETA-GLOBIN - LOCUS-CONTROL REGION HYPERSENSITIVE SITE-2 AS REVEALED BY 4 NITROGEN MUSTARDS, Nucleic acids research, 25(16), 1997, pp. 3255-3260
INTERACTION OF THE ANTITUMOR ANTIBIOTIC STREPTONIGRIN WITH DNA AND OLIGONUCLEOTIDES
Authors: LONG GV HARDING MM FAN JY DENNY WA
Citation: Gv. Long et al., INTERACTION OF THE ANTITUMOR ANTIBIOTIC STREPTONIGRIN WITH DNA AND OLIGONUCLEOTIDES, Anti-cancer drug design, 12(6), 1997, pp. 453-472
SYNTHESIS, DNA-BINDING AND CYTOTOXICITY OF LKYL]CARBONYL-3-(CHLOROMETHYL)-6-HYDROXYINDOLINES, A NEW CLASS OF DNA-TARGETED ALKYLATING-AGENTS
Authors: FAN JY TERCEL M DENNY WA
Citation: Jy. Fan et al., SYNTHESIS, DNA-BINDING AND CYTOTOXICITY OF LKYL]CARBONYL-3-(CHLOROMETHYL)-6-HYDROXYINDOLINES, A NEW CLASS OF DNA-TARGETED ALKYLATING-AGENTS, Anti-cancer drug design, 12(4), 1997, pp. 277-293
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