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Results: 1-16 |
Results: 16
USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS - CRYSTAL-STRUCTURES OF 2 PAPAIN-INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES
Authors: LALONDE JM ZHAO BG SMITH WW JANSON CA DESJARLAIS RL TOMASZEK TA CARR TJ THOMPSON SK OH HJ YAMASHITA DS VEBER DF ABDELMEGUID SS
Citation: Jm. Lalonde et al., USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS - CRYSTAL-STRUCTURES OF 2 PAPAIN-INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES, Journal of medicinal chemistry, 41(23), 1998, pp. 4567-4576
STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS CONTAINING A BENZYLOXY-SUBSTITUTED BENZOYL PEPTIDOMIMETIC
Authors: THOMPSON SK SMITH WW ZHAO BG HALBERT SM TOMASZEK TA TEW DG LEVY MA JANSON CA DALESSIO KJ MCQUENEY MS KURDYLA J JONES CS DESJARLAIS RL ABDELMEGUID SS VEBER DF
Citation: Sk. Thompson et al., STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS CONTAINING A BENZYLOXY-SUBSTITUTED BENZOYL PEPTIDOMIMETIC, Journal of medicinal chemistry, 41(21), 1998, pp. 3923-3927
CONFORMATIONALLY CONSTRAINED 1,3-DIAMINO KETONES - A SERIES OF POTENTINHIBITORS OF THE CYSTEINE PROTEASE CATHEPSIN-K
Authors: MARQUIS RW YAMASHITA DS RU Y LOCASTRO SM OH HJ ERHARD KF DESJARLAIS RL HEAD MS SMITH WW ZHAO BG JANSON CA ABDELMEGUID SS TOMASZEK TA LEVY MA VEBER DF
Citation: Rw. Marquis et al., CONFORMATIONALLY CONSTRAINED 1,3-DIAMINO KETONES - A SERIES OF POTENTINHIBITORS OF THE CYSTEINE PROTEASE CATHEPSIN-K, Journal of medicinal chemistry, 41(19), 1998, pp. 3563-3567
USE OF X-RAY CO-CRYSTAL STRUCTURES AND MOLECULAR MODELING TO DESIGN POTENT AND SELECTIVE NONPEPTIDE INHIBITORS OF CATHEPSIN-K
Authors: DESJARLAIS RL YAMASHITA DS OH HJ UZINSKAS IN ERHARD KF ALLEN AC HALTIWANGER RC ZHAO BG SMITH WW ABDELMEGUID SS DALESSIO K JANSON CA MCQUENEY MS TOMASZEK TA LEVY MA VEBER DF
Citation: Rl. Desjarlais et al., USE OF X-RAY CO-CRYSTAL STRUCTURES AND MOLECULAR MODELING TO DESIGN POTENT AND SELECTIVE NONPEPTIDE INHIBITORS OF CATHEPSIN-K, Journal of the American Chemical Society, 120(35), 1998, pp. 9114-9115
PYRROLOOCTAHYDROISOQUINOLINES AS POTENT AND SELECTIVE DELTA-OPIOID RECEPTOR LIGANDS - SAR ANALYSIS AND DOCKING STUDIES
Authors: DONDIO G RONZONI S PETRILLO P DESJARLAIS RL RAVEGLIA LF
Citation: G. Dondio et al., PYRROLOOCTAHYDROISOQUINOLINES AS POTENT AND SELECTIVE DELTA-OPIOID RECEPTOR LIGANDS - SAR ANALYSIS AND DOCKING STUDIES, Bioorganic & medicinal chemistry letters, 7(23), 1997, pp. 2967-2972
DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE
Authors: THOMPSON SK HALBERT SM BOSSARD MJ TOMASZEK TA LEVY MA ZHAO BG SMITH WW ABDELMEGUID SS JANSON CA DALESSIO KJ MCQUENEY MS AMEGADZIE BY HANNING CR DESJARLAIS RL BRIAND J SARKAR SK HUDDLESTON MJ IJAMES CF CARR SA GARNES KT SHU A HEYS JR BRADBEER J ZEMBRYKI D LEERYKACZEWSKI L JAMES IE LARK MW DRAKE FH GOWEN M GLEASON JG VEBER DF
Citation: Sk. Thompson et al., DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(26), 1997, pp. 14249-14254
STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS
Authors: YAMASHITA DS SMITH WW ZHAO BG JANSON CA TOMASZEK TA BOSSARD MJ LEVY MA OH HJ CARR TJ THOMPSON SK IJAMES CF CARR SA MCQUENEY M DALESSIO KJ AMEGADZIE BY HANNING CR ABDELMEGUID S DESJARLAIS RL GLEASON JG VEBER DF
Citation: Ds. Yamashita et al., STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS, Journal of the American Chemical Society, 119(46), 1997, pp. 11351-11352
DETERMINATION OF THE AMINO-ACID RESIDUE INVOLVED IN [H-13]BETA-FUNALTREXAMINE COVALENT BINDING IN THE CLONED RAT MU-OPIOID RECEPTOR
Authors: CHEN CG YIN YL DERIEL JK DESJARLAIS RL RAVEGLIA LF ZHU JM LIUCHEN LY
Citation: Cg. Chen et al., DETERMINATION OF THE AMINO-ACID RESIDUE INVOLVED IN [H-13]BETA-FUNALTREXAMINE COVALENT BINDING IN THE CLONED RAT MU-OPIOID RECEPTOR, The Journal of biological chemistry, 271(35), 1996, pp. 21422-21429
A PARADIGM FOR DRUG DISCOVERY USING A CONFORMATION FROM THE CRYSTAL-STRUCTURE OF A PRESENTATION SCAFFOLD
Authors: ZHAO BG HELMS LR DESJARLAIS RL ABDELMEGUID SS WETZEL R
Citation: Bg. Zhao et al., A PARADIGM FOR DRUG DISCOVERY USING A CONFORMATION FROM THE CRYSTAL-STRUCTURE OF A PRESENTATION SCAFFOLD, Nature structural biology, 2(12), 1995, pp. 1131-1137
A CHECK ON RATIONAL DRUG DESIGN - CRYSTAL-STRUCTURE OF A COMPLEX OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC INHIBITOR
Authors: HOOG SS ZHAO BG WINBORNE E FISHER S GREEN DW DESJARLAIS RL NEWLANDER KA CALLAHAN JF MOORE ML HUFFMAN WF ABDELMEGUID SS
Citation: Ss. Hoog et al., A CHECK ON RATIONAL DRUG DESIGN - CRYSTAL-STRUCTURE OF A COMPLEX OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC INHIBITOR, Journal of medicinal chemistry, 38(17), 1995, pp. 3246-3252
A SHAPE-BASED AND CHEMISTRY-BASED DOCKING METHOD AND ITS USE IN THE DESIGN OF HIV-1 PROTEASE INHIBITORS
Authors: DESJARLAIS RL DIXON JS
Citation: Rl. Desjarlais et Js. Dixon, A SHAPE-BASED AND CHEMISTRY-BASED DOCKING METHOD AND ITS USE IN THE DESIGN OF HIV-1 PROTEASE INHIBITORS, Journal of computer-aided molecular design, 8(3), 1994, pp. 231-242
RATIONAL DESIGN, SYNTHESIS, AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P-1' P-2' AMIDE BOND ISOSTERE
Authors: THOMPSON SK MURTHY KHM ZHAO B WINBORNE E GREEN DW FISHER SM DESJARLAIS RL TOMASZEK TA MEEK TD GLEASON JG ABDELMEGUID SS
Citation: Sk. Thompson et al., RATIONAL DESIGN, SYNTHESIS, AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P-1' P-2' AMIDE BOND ISOSTERE, Journal of medicinal chemistry, 37(19), 1994, pp. 3100-3107
AN ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE-BOND REPLACEMENT - CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS
Authors: ABDELMEGUID SS METCALF BW CARR TJ DEMARSH P DESJARLAIS RL FISHER S GREEN DW IVANOFF L LAMBERT DM MURTHY KHM PETTEWAY SR PITTS WJ TOMASZEK TA WINBORNE E ZHAO BG DREYER GB MEEK TD
Citation: Ss. Abdelmeguid et al., AN ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE-BOND REPLACEMENT - CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS, Biochemistry, 33(39), 1994, pp. 11671-11677
NONPEPTIDE HIV PROTEASE INHIBITORS DESIGNED TO REPLACE A BOUND WATER
Authors: CHENERA B DESJARLAIS RL FINKELSTEIN JA EGGLESTON DS MEEK TD TOMASZEK TA DREYER GB
Citation: B. Chenera et al., NONPEPTIDE HIV PROTEASE INHIBITORS DESIGNED TO REPLACE A BOUND WATER, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2717-2722
STRONG INHIBITION OF FIBRINOGEN BINDING TO PLATELET RECEPTOR -ALPHA-IIB-BETA-3 BY RGD SEQUENCES INSTALLED INTO A PRESENTATION SCAFFOLD
Authors: LEE G CHAN W HURLE MR DESJARLAIS RL WATSON F SATHE GM WETZEL R
Citation: G. Lee et al., STRONG INHIBITION OF FIBRINOGEN BINDING TO PLATELET RECEPTOR -ALPHA-IIB-BETA-3 BY RGD SEQUENCES INSTALLED INTO A PRESENTATION SCAFFOLD, Protein engineering, 6(7), 1993, pp. 745-754
INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRICAL PHOSPHINATE - SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS
Authors: ABDELMEGUID SS ZHAO BG MURTHY KHM WINBORNE E CHOI JK DESJARLAIS RL MINNICH MD CULP JS DEBOUCK C TOMASZEK TA MEEK TD DREYER GB
Citation: Ss. Abdelmeguid et al., INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRICAL PHOSPHINATE - SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS, Biochemistry, 32(31), 1993, pp. 7972-7980
Risultati: 1-16 |