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Results: 1-25 | 26-29
Results: 1-25/29
DOWN-REGULATION OF PS1 EXPRESSION IN NEURONS DECREASES BETA-AMYLOID PRODUCTION - A BIOCHEMICAL LINK BETWEEN THE 2 MAJOR FAMILIAL ALZHEIMERS-DISEASE GENES
Authors: SAFTIG P DESTROOPER B
Citation: P. Saftig et B. Destrooper, DOWN-REGULATION OF PS1 EXPRESSION IN NEURONS DECREASES BETA-AMYLOID PRODUCTION - A BIOCHEMICAL LINK BETWEEN THE 2 MAJOR FAMILIAL ALZHEIMERS-DISEASE GENES, Molecular psychiatry, 3(4), 1998, pp. 287-289
INTRACELLULAR TRAFFICKING AND PROCESSING OF GPI-LINKED APP MUTANT PROTEIN SHOW DIFFERENTIAL PROCESSING BY SECRETASES ON THE POLARIZED PATHWAYS
Authors: EASTMAN J CRAESSAERTS K DESTROOPER B PIMPLIKAR SW
Citation: J. Eastman et al., INTRACELLULAR TRAFFICKING AND PROCESSING OF GPI-LINKED APP MUTANT PROTEIN SHOW DIFFERENTIAL PROCESSING BY SECRETASES ON THE POLARIZED PATHWAYS, Molecular biology of the cell, 9, 1998, pp. 1213-1213
TRANSGENIC MICE EXPRESSING AN ALPHA-SECRETION MUTANT OF THE AMYLOID PRECURSOR PROTEIN IN THE BRAIN DEVELOP A PROGRESSIVE CNS DISORDER
Authors: MOECHARS D LORENT K DEWACHTER I BAEKELANDT V DESTROOPER B VANLEUVEN F
Citation: D. Moechars et al., TRANSGENIC MICE EXPRESSING AN ALPHA-SECRETION MUTANT OF THE AMYLOID PRECURSOR PROTEIN IN THE BRAIN DEVELOP A PROGRESSIVE CNS DISORDER, Behavioural brain research, 95(1), 1998, pp. 55-64
DESTABILIZATION OF BETA-CATENIN BY MUTATIONS IN PRESENILIN-1 POTENTIATES NEURONAL APOPTOSIS
Authors: ZHANG ZH HARTMANN H DO VM ABRAMOWSKI D STURCHLERPIERRAT C STAUFENBIEL M SOMMER B VANDEWETERING M CLEVERS H SAFTIG P DESTROOPER B HE X YANKNER BA
Citation: Zh. Zhang et al., DESTABILIZATION OF BETA-CATENIN BY MUTATIONS IN PRESENILIN-1 POTENTIATES NEURONAL APOPTOSIS, Nature, 395(6703), 1998, pp. 698-702
DEFICIENCY OF PRESENILIN-1 INHIBITS THE NORMAL CLEAVAGE OF AMYLOID PRECURSOR PROTEIN
Authors: DESTROOPER B SAFTIG P CRAESSAERTS K VANDERSTICHELE H GUHDE G ANNAERT W VONFIGURA K VANLEUVEN F
Citation: B. Destrooper et al., DEFICIENCY OF PRESENILIN-1 INHIBITS THE NORMAL CLEAVAGE OF AMYLOID PRECURSOR PROTEIN, Nature, 391(6665), 1998, pp. 387-390
CHOLESTEROL DEPLETION INHIBITS THE GENERATION OF BETA-AMYLOID IN HIPPOCAMPAL-NEURONS
Authors: SIMONS M KELLER P DESTROOPER B BEYREUTHER K DOTTI CG SIMONS K
Citation: M. Simons et al., CHOLESTEROL DEPLETION INHIBITS THE GENERATION OF BETA-AMYLOID IN HIPPOCAMPAL-NEURONS, Proceedings of the National Academy of Sciences of the United Statesof America, 95(11), 1998, pp. 6460-6464
BIOLOGY AND GENETICS OF THE PRESENILIN PROTEINS ASSOCIATED WITH ALZHEIMER-DISEASE
Authors: STGEORGEHYSLOP P LEVESQUE G YU G IKEDA M NISHIMURA M ROGAEVA E MORI H DESTROOPER B HAASS C SELKOE D WESTAWAY D FRASER P
Citation: P. Stgeorgehyslop et al., BIOLOGY AND GENETICS OF THE PRESENILIN PROTEINS ASSOCIATED WITH ALZHEIMER-DISEASE, The FASEB journal, 11(9), 1997, pp. 866-866
BIOLOGY AND GENETICS OF THE PRESENILIN PROTEINS ASSOCIATED WITH ALZHEIMER-DISEASE
Authors: STGEORGEHYSLOP P LEVESQUE G YU G IKEDA M NISHIMURA M ROGAEVA E MORI H DESTROOPER B HAASS C SELKOE D WESTAWAY D FRASER P
Citation: P. Stgeorgehyslop et al., BIOLOGY AND GENETICS OF THE PRESENILIN PROTEINS ASSOCIATED WITH ALZHEIMER-DISEASE, Journal of neurochemistry, 69, 1997, pp. 5-5
PHOSPHORYLATION, SUBCELLULAR-LOCALIZATION, AND MEMBRANE ORIENTATION OF THE ALZHEIMERS DISEASE-ASSOCIATED PRESENILINS
Authors: DESTROOPER B BEULLENS M CONTRERAS B LEVESQUE L CRAESSAERTS K CORDELL B MOECHARS D BOLLEN M FRASER P STGEORGEHYSLOP P VANLEUVEN F
Citation: B. Destrooper et al., PHOSPHORYLATION, SUBCELLULAR-LOCALIZATION, AND MEMBRANE ORIENTATION OF THE ALZHEIMERS DISEASE-ASSOCIATED PRESENILINS, The Journal of biological chemistry, 272(6), 1997, pp. 3590-3598
A 68-KD ANTIGEN, WHICH IS PROBABLY AN N-TERMINAL FRAGMENT OF THE VLA-5 ALPHA(5)-SUBUNIT, IS SPECIFIC FOR DIFFERENTIATING KERATINOCYTES
Authors: DESTROOPER B WU RR JASPERS M VANDERSCHUEREN B VEKEMANS S CARMELIET G VANLEUVEN F VANDENOORD J CASSIMAN JJ
Citation: B. Destrooper et al., A 68-KD ANTIGEN, WHICH IS PROBABLY AN N-TERMINAL FRAGMENT OF THE VLA-5 ALPHA(5)-SUBUNIT, IS SPECIFIC FOR DIFFERENTIATING KERATINOCYTES, Dermatology, 193(3), 1996, pp. 212-220
AMYLOIDOGENIC PROCESSING OF THE HUMAN AMYLOID PRECURSOR PROTEIN IN PRIMARY CULTURES OF RAT HIPPOCAMPAL-NEURONS
Authors: SIMONS M DESTROOPER B MULTHAUP G TIENARI PJ DOTTI CG BEYREUTHER K
Citation: M. Simons et al., AMYLOIDOGENIC PROCESSING OF THE HUMAN AMYLOID PRECURSOR PROTEIN IN PRIMARY CULTURES OF RAT HIPPOCAMPAL-NEURONS, The Journal of neuroscience, 16(3), 1996, pp. 899-908
EXPRESSION IN BRAIN OF AMYLOID PRECURSOR PROTEIN MUTATED IN THE ALPHA-SECRETASE SITE CAUSES DISTURBED BEHAVIOR, NEURONAL DEGENERATION AND PREMATURE DEATH IN TRANSGENIC MICE
Authors: MOECHARS D LORENT K DESTROOPER B DEWACHTER I VANLEUVEN F
Citation: D. Moechars et al., EXPRESSION IN BRAIN OF AMYLOID PRECURSOR PROTEIN MUTATED IN THE ALPHA-SECRETASE SITE CAUSES DISTURBED BEHAVIOR, NEURONAL DEGENERATION AND PREMATURE DEATH IN TRANSGENIC MICE, EMBO journal, 15(6), 1996, pp. 1265-1274
THE BETA-AMYLOID DOMAIN IS ESSENTIAL FOR AXONAL SORTING OF AMYLOID PRECURSOR PROTEIN
Authors: TIENARI PJ DESTROOPER B IKONEN E SIMONS M WEIDEMANN A CZECH C HARTMANN T IDA N MULTHAUP G MASTERS CL VANLEUVEN F BEYREUTHER K DOTTI CG
Citation: Pj. Tienari et al., THE BETA-AMYLOID DOMAIN IS ESSENTIAL FOR AXONAL SORTING OF AMYLOID PRECURSOR PROTEIN, EMBO journal, 15(19), 1996, pp. 5218-5229
NEURONAL SORTING AND PROCESSING OF AMYLOID PRECURSOR PROTEIN - IMPLICATIONS FOR ALZHEIMERS-DISEASE
Authors: TIENARI PJ DESTROOPER B IKONEN E IDA N SIMONS M MASTERS CL DOTTI CG BEYREUTHER K
Citation: Pj. Tienari et al., NEURONAL SORTING AND PROCESSING OF AMYLOID PRECURSOR PROTEIN - IMPLICATIONS FOR ALZHEIMERS-DISEASE, Cold Spring Harbor Symposia on Quantitative Biology, 61, 1996, pp. 575-585
AMYLOIDOGENIC PROCESSING OF HUMAN AMYLOID PRECURSOR PROTEIN IN HIPPOCAMPAL-NEURONS DEVOID OF CATHEPSIN-D
Authors: SAFTIG P PETERS C VONFIGURA K CRAESSAERTS K VANLEUVEN F DESTROOPER B
Citation: P. Saftig et al., AMYLOIDOGENIC PROCESSING OF HUMAN AMYLOID PRECURSOR PROTEIN IN HIPPOCAMPAL-NEURONS DEVOID OF CATHEPSIN-D, The Journal of biological chemistry, 271(44), 1996, pp. 27241-27244
AMYLOID PRECURSOR PROTEIN ACCUMULATION IN LEWY BODY DEMENTIA AND ALZHEIMERS-DISEASE
Authors: VANGOOL D DESTROOPER B VANLEUVEN F DOM R
Citation: D. Vangool et al., AMYLOID PRECURSOR PROTEIN ACCUMULATION IN LEWY BODY DEMENTIA AND ALZHEIMERS-DISEASE, Dementia, 6(2), 1995, pp. 63-68
CLONING, CHARACTERIZATION, AND CHROMOSOMAL LOCALIZATION TO 4P16 OF THE HUMAN GENE (LRPAP1) CODING FOR THE ALPHA-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN AND STRUCTURAL COMPARISON WITH THE MURINE GENE CODING FOR THE 44-KDA HEPARIN-BINDING PROTEIN
Authors: VANLEUVEN F HILLIKER C SERNEELS L UMANS L OVERBERGH L DESTROOPER B FRYNS JP VANDENBERGHE H
Citation: F. Vanleuven et al., CLONING, CHARACTERIZATION, AND CHROMOSOMAL LOCALIZATION TO 4P16 OF THE HUMAN GENE (LRPAP1) CODING FOR THE ALPHA-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN AND STRUCTURAL COMPARISON WITH THE MURINE GENE CODING FOR THE 44-KDA HEPARIN-BINDING PROTEIN, Genomics, 25(2), 1995, pp. 492-500
EXPRESSION IN MOUSE EMBRYOS AND IN ADULT-MOUSE BRAIN OF 3 MEMBERS OF THE AMYLOID PRECURSOR PROTEIN FAMILY, OF THE ALPHA-2-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN AND OF ITS LIGANDS APOLIPOPROTEIN-E, LIPOPROTEIN-LIPASE, ALPHA-2-MACROGLOBULIN AND THE 40,000-MOLECULAR-WEIGHT RECEPTOR-ASSOCIATED PROTEIN
Authors: LORENT K OVERBERGH L MOECHARS D DESTROOPER B VANLEUVEN F VANDENBERGHE H
Citation: K. Lorent et al., EXPRESSION IN MOUSE EMBRYOS AND IN ADULT-MOUSE BRAIN OF 3 MEMBERS OF THE AMYLOID PRECURSOR PROTEIN FAMILY, OF THE ALPHA-2-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN AND OF ITS LIGANDS APOLIPOPROTEIN-E, LIPOPROTEIN-LIPASE, ALPHA-2-MACROGLOBULIN AND THE 40,000-MOLECULAR-WEIGHT RECEPTOR-ASSOCIATED PROTEIN, Neuroscience, 65(4), 1995, pp. 1009-1025
PRODUCTION OF INTRACELLULAR AMYLOID-CONTAINING FRAGMENTS IN HIPPOCAMPAL-NEURONS EXPRESSING HUMAN AMYLOID PRECURSOR PROTEIN AND PROTECTION AGAINST AMYLOIDOGENESIS BY SUBTLE AMINO-ACID SUBSTITUTIONS IN THE RODENT SEQUENCE
Authors: DESTROOPER B SIMONS M MULTHAUP G VANLEUVEN F BEYREUTHER K DOTTI CG
Citation: B. Destrooper et al., PRODUCTION OF INTRACELLULAR AMYLOID-CONTAINING FRAGMENTS IN HIPPOCAMPAL-NEURONS EXPRESSING HUMAN AMYLOID PRECURSOR PROTEIN AND PROTECTION AGAINST AMYLOIDOGENESIS BY SUBTLE AMINO-ACID SUBSTITUTIONS IN THE RODENT SEQUENCE, EMBO journal, 14(20), 1995, pp. 4932-4938
AMYLOID PRECURSOR PROTEIN IS NOT PROCESSED BY FURIN, PACE-4, PC1 3, PC2, PC4 AND PC5/6 OF THE FURIN FAMILY OF PROPROTEIN PROCESSING ENZYMES/
Authors: DESTROOPER B CREEMERS JWM MOECHARS D HUYLEBROECK D VANDEVEN WJM VANLEUVEN F VANDENBERGHE H
Citation: B. Destrooper et al., AMYLOID PRECURSOR PROTEIN IS NOT PROCESSED BY FURIN, PACE-4, PC1 3, PC2, PC4 AND PC5/6 OF THE FURIN FAMILY OF PROPROTEIN PROCESSING ENZYMES/, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1246(2), 1995, pp. 185-188
BASOLATERAL SECRETION OF AMYLOID PRECURSOR PROTEIN IN MADIN-DARBY CANINE KIDNEY-CELLS IS DISTURBED BY ALTERATIONS OF INTRACELLULAR PH AND BY INTRODUCING A MUTATION ASSOCIATED WITH FAMILIAL ALZHEIMERS-DISEASE
Authors: DESTROOPER B CRAESSAERTS K DEWACHTER I MOECHARS D GREENBERG B VANLEUVEN F VANDENBERGHE H
Citation: B. Destrooper et al., BASOLATERAL SECRETION OF AMYLOID PRECURSOR PROTEIN IN MADIN-DARBY CANINE KIDNEY-CELLS IS DISTURBED BY ALTERATIONS OF INTRACELLULAR PH AND BY INTRODUCING A MUTATION ASSOCIATED WITH FAMILIAL ALZHEIMERS-DISEASE, The Journal of biological chemistry, 270(8), 1995, pp. 4058-4065
EXCHANGING THE EXTRACELLULAR DOMAIN OF AMYLOID PRECURSOR PROTEIN FOR HORSERADISH-PEROXIDASE DOES NOT INTERFERE WITH ALPHA-SECRETASE CLEAVAGE OF THE BETA-AMYLOID REGION, BUT RANDOMIZES SECRETION IN MADIN-DARBY CANINE KIDNEY-CELLS
Authors: DESTROOPER B CRAESSAERTS K VANLEUVEN F VANDENBERGHE H
Citation: B. Destrooper et al., EXCHANGING THE EXTRACELLULAR DOMAIN OF AMYLOID PRECURSOR PROTEIN FOR HORSERADISH-PEROXIDASE DOES NOT INTERFERE WITH ALPHA-SECRETASE CLEAVAGE OF THE BETA-AMYLOID REGION, BUT RANDOMIZES SECRETION IN MADIN-DARBY CANINE KIDNEY-CELLS, The Journal of biological chemistry, 270(51), 1995, pp. 30310-30314
MOLECULAR AND BEHAVIORAL CHARACTERIZATION OF TRANSGENIC MICE EXPRESSING MUTANT APP IN THE BRAIN
Authors: MOECHARS D DESTROOPER B VANLEUVEN F
Citation: D. Moechars et al., MOLECULAR AND BEHAVIORAL CHARACTERIZATION OF TRANSGENIC MICE EXPRESSING MUTANT APP IN THE BRAIN, Behavior genetics, 25(3), 1995, pp. 280-280
STRUCTURE OF THE GENE (LRP1) CODING FOR THE HUMAN ALPHA(2)-MACROGLOBULIN RECEPTOR LIPOPROTEIN RECEPTOR-RELATED PROTEIN
Authors: VANLEUVEN F STAS L HILLIKER C LORENT K UMANS L SERNEELS L OVERBERGH L TORREKENS S MOECHARS D DESTROOPER B VANDENBERGHE H
Citation: F. Vanleuven et al., STRUCTURE OF THE GENE (LRP1) CODING FOR THE HUMAN ALPHA(2)-MACROGLOBULIN RECEPTOR LIPOPROTEIN RECEPTOR-RELATED PROTEIN, Genomics, 24(1), 1994, pp. 78-89
MOLECULAR-CLONING OF THE MOUSE GENE CODING FOR ALPHA(2)-MACROGLOBULINAND TARGETING OF THE GENE IN EMBRYONIC STEM-CELLS
Authors: UMANS L SERNEELS L HILLIKER C STAS L OVERBERGH L DESTROOPER B VANLEUVEN F VANDENBERGHE H
Citation: L. Umans et al., MOLECULAR-CLONING OF THE MOUSE GENE CODING FOR ALPHA(2)-MACROGLOBULINAND TARGETING OF THE GENE IN EMBRYONIC STEM-CELLS, Genomics, 22(3), 1994, pp. 519-529
Risultati: 1-25 | 26-29