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Results: 1-13 |
Results: 13
L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR
Authors: SANDERSON PEJ CUTRONA KJ DORSEY BD DYER DL MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ GARDELL SJ KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 817-822
EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES
Authors: SANDERSON PEJ LYLE TA CUTRONA KJ DYER DL DORSEY BD MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ COOPER CM GARDELL SJ HARE TR KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K YAN YW SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES, Journal of medicinal chemistry, 41(23), 1998, pp. 4466-4474
METABOLITE-P450 COMPLEX-FORMATION BY METHYLENEDIOXYPHENYL HIV PROTEASE INHIBITORS IN RAT AND HUMAN LIVER-MICROSOMES
Authors: CHIBA M NISHIME JA CHEN IW VASTAG KJ SAHLY YS KIM BM DORSEY BD VACCA JP LIN JH
Citation: M. Chiba et al., METABOLITE-P450 COMPLEX-FORMATION BY METHYLENEDIOXYPHENYL HIV PROTEASE INHIBITORS IN RAT AND HUMAN LIVER-MICROSOMES, Biochemical pharmacology, 56(2), 1998, pp. 223-230
CRIXIVAN(R) - A POTENT INHIBITOR OF HIV-1 PROTEASE IN-VIVO
Authors: HUFF JR VACCA JP DORSEY BD EMINI EA CONDRA JH SCHLEIF WA MASSARI FE DEUTSCH PJ CHODAKEWITZ J KUO LC CHEN Z
Citation: Jr. Huff et al., CRIXIVAN(R) - A POTENT INHIBITOR OF HIV-1 PROTEASE IN-VIVO, The FASEB journal, 11(9), 1997, pp. 23-23
A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE (VOL 38, PG 308, 1995)
Authors: HOLLOWAY MK WAI JM HALGREN TA FITZGERALD PMD VACCA JP DORSEY BD LEVIN RB THOMPSON WJ CHEN LJ DESOLMS SJ GAFFIN N GHOSH AK GIULIANI EA GRAHAM SL GUARE JP HUNGATE RW LYLE TA SANDERS WM TUCKER TJ WIGGINS M WISCOUNT CM WOLTERSDORF OW YOUNG SD DARKE PL ZUGAY JA
Citation: Mk. Holloway et al., A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE (VOL 38, PG 308, 1995), Journal of medicinal chemistry, 39(11), 1996, pp. 2280-2280
SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS (VOL 4, PG 2769, 1994)
Authors: DORSEY BD MCDANIEL SL LEVIN RB VACCA JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS (VOL 4, PG 2769, 1994), Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 773-773
TIME-DEPENDENT AND DOSE-DEPENDENT PHARMACOKINETICS OF L-754,394, AN HIV PROTEASE INHIBITOR, IN RATS, DOGS AND MONKEYS
Authors: LIN JH CHIBA M CHEN IW VASTAG KJ NISHIME JA DORSEY BD MICHELSON SR MCDANIEL SL
Citation: Jh. Lin et al., TIME-DEPENDENT AND DOSE-DEPENDENT PHARMACOKINETICS OF L-754,394, AN HIV PROTEASE INHIBITOR, IN RATS, DOGS AND MONKEYS, The Journal of pharmacology and experimental therapeutics, 274(1), 1995, pp. 264-269
A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE
Authors: HOLLOWAY MK WAI JM HALGREN TA FITZGERALD PMD VACCA JP DORSEY BD LEVIN RB THOMPSON WJ CHEN LJ DESOLMS SJ GAFFIN N GHOSH AK GIULIANI EA GRAHAM SL GUARE JP HUNGATE RW LYLE TA SANDERS WM TUCKER TJ WIGGINS M WISCOUNT CM WOLTERSDORF OW YOUNG SD DARKE PL ZUGAY JA
Citation: Mk. Holloway et al., A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE, Journal of medicinal chemistry, 38(2), 1995, pp. 305-317
A PRACTICAL SYNTHESIS OF 5-(CHLOROMETHYL)FURO[2,3-B]PYRIDINE, A KEY INTERMEDIATE FOR THE HIV PROTEASE INHIBITOR, L-754,394
Authors: BHUPATHY M CONLON DA WELLS KM NELSON JR REIDER PJ ROSSEN K SAGER JW VOLANTE RP DORSEY BD HOFFMAN JM JOSEPH SA MCDANIEL SL
Citation: M. Bhupathy et al., A PRACTICAL SYNTHESIS OF 5-(CHLOROMETHYL)FURO[2,3-B]PYRIDINE, A KEY INTERMEDIATE FOR THE HIV PROTEASE INHIBITOR, L-754,394, Journal of heterocyclic chemistry, 32(4), 1995, pp. 1283-1287
SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS
Authors: DORSEY BD MCDANIEL SL LEVIN RB VACCA JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 4(23), 1994, pp. 2769-2774
THE DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS
Authors: HUFF JR VACCA JP DORSEY BD THOMPSON WJ GHOSH AK HUNGATE RW LEE HY DARKE PL EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS
Citation: Jr. Huff et al., THE DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS, Journal of cellular biochemistry, 1994, pp. 130-130
L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR
Authors: VACCA JP DORSEY BD SCHLEIF WA LEVIN RB MCDANIEL SL DARKE PL ZUGAY J QUINTERO JC BLAHY OM ROTH E SARDANA VV SCHLABACH AJ GRAHAM PI CONDRA JH GOTLIB L HOLLOWAY MK LIN J CHEN IW VASTAG K OSTOVIC D ANDERSON PS EMINI EA HUFF JR
Citation: Jp. Vacca et al., L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR, Proceedings of the National Academy of Sciences of the United Statesof America, 91(9), 1994, pp. 4096-4100
L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR
Authors: DORSEY BD LEVIN RB MCDANIEL SL VACCA JP GUARE JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA QUINTERO JC LIN JH CHEN IW HOLLOWAY MK FITZGERALD PMD AXEL MG OSTOVIC D ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR, Journal of medicinal chemistry, 37(21), 1994, pp. 3443-3451
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