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Results: 1-25 | 26-34
Results: 1-25/34
INHIBITORS OF GLUTATHIONE-REDUCTASE AS POTENTIAL ANTIMALARIAL-DRUGS -KINETIC COOPERATIVITY AND EFFECT OF DIMETHYL-SULFOXIDE ON INHIBITION-KINETICS
Authors: LUOND RM MCKIE JH DOUGLAS KT DASCOMBE MJ VALE J
Citation: Rm. Luond et al., INHIBITORS OF GLUTATHIONE-REDUCTASE AS POTENTIAL ANTIMALARIAL-DRUGS -KINETIC COOPERATIVITY AND EFFECT OF DIMETHYL-SULFOXIDE ON INHIBITION-KINETICS, Journal of enzyme inhibition, 13(5), 1998, pp. 327-345
STRONG, SPECIFIC, REVERSIBLE BINDING LIGANDS FOR TRANSFER-RNA - COMPARISON BY FLUORESCENCE AND NMR SPECTROSCOPIES WITH DISTAMYCIN BINDING FOR A NEW STRUCTURAL CLASS OF LIGAND
Authors: BICHENKOVA EV SADATEBRAHIMI SE WILTON AN OTOOLE N MARKS DS DOUGLAS KT
Citation: Ev. Bichenkova et al., STRONG, SPECIFIC, REVERSIBLE BINDING LIGANDS FOR TRANSFER-RNA - COMPARISON BY FLUORESCENCE AND NMR SPECTROSCOPIES WITH DISTAMYCIN BINDING FOR A NEW STRUCTURAL CLASS OF LIGAND, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1651-1665
RATIONAL DRUG DESIGN APPROACH FOR OVERCOMING DRUG-RESISTANCE - APPLICATION TO PYRIMETHAMINE RESISTANCE IN MALARIA
Authors: MCKIE JH DOUGLAS KT CHAN C ROSER SA YATES R READ M HYDE JE DASCOMBE MJ YUTHAVONG Y SIRAWARAPORN W
Citation: Jh. Mckie et al., RATIONAL DRUG DESIGN APPROACH FOR OVERCOMING DRUG-RESISTANCE - APPLICATION TO PYRIMETHAMINE RESISTANCE IN MALARIA, Journal of medicinal chemistry, 41(9), 1998, pp. 1367-1370
PHENOTHIAZINE INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL AND ANTILEISHMANIAL DRUGS (VOL 41, PG 150, 1998)
Authors: CHAN C YIN H GARFORTH J MCKIE JH JAOUHARI R SPEERS P DOUGLAS KT ROCK PJ YARDLEY V CROFT SL FAIRLAMB AH
Citation: C. Chan et al., PHENOTHIAZINE INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL AND ANTILEISHMANIAL DRUGS (VOL 41, PG 150, 1998), Journal of medicinal chemistry, 41(24), 1998, pp. 4910-4910
PHENOTHIAZINE INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL AND ANTILEISHMANIAL DRUGS
Authors: CHAN C YIN H GARFORTH J MCKIE JH JAOUHARI R SPEERS P DOUGLAS KT ROCK PJ YARDLEY V CROFT SL FAIRLAMB AH
Citation: C. Chan et al., PHENOTHIAZINE INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL AND ANTILEISHMANIAL DRUGS, Journal of medicinal chemistry, 41(2), 1998, pp. 148-156
RATIONAL DESIGN OF SELECTIVE LIGANDS FOR TRYPANOTHIONE REDUCTASE FROMTRYPANOSOMA-CRUZI - STRUCTURAL EFFECTS ON THE INHIBITION BY DIBENZAZEPINES BASED ON IMIPRAMINE
Authors: GARFORTH J YIN H MCKIE JH DOUGLAS KT FAIRLAMB AH
Citation: J. Garforth et al., RATIONAL DESIGN OF SELECTIVE LIGANDS FOR TRYPANOTHIONE REDUCTASE FROMTRYPANOSOMA-CRUZI - STRUCTURAL EFFECTS ON THE INHIBITION BY DIBENZAZEPINES BASED ON IMIPRAMINE, Journal of enzyme inhibition, 12(3), 1997, pp. 161-173
UNIQUE BINDING-SITE FOR BIS-BENZIMIDAZOLES ON TRANSFER-RNA
Authors: EBRAHIMI SES WILTON AN DOUGLAS KT
Citation: Ses. Ebrahimi et al., UNIQUE BINDING-SITE FOR BIS-BENZIMIDAZOLES ON TRANSFER-RNA, Chemical communications, (4), 1997, pp. 385-386
SYNTHESIS AND CHARACTERIZATION OF D-AMINO ACID-BASED OLIGOPEPTIDES FOR USE AS PROBES OF THE INFLUENCE OF MOLECULAR-STRUCTURE ON THE PARACELLULAR ROUTE OF GASTROINTESTINAL DRUG UPTAKE
Authors: WILCOCK R SPEERS P WARHURST G ROWLAND M DOUGLAS KT
Citation: R. Wilcock et al., SYNTHESIS AND CHARACTERIZATION OF D-AMINO ACID-BASED OLIGOPEPTIDES FOR USE AS PROBES OF THE INFLUENCE OF MOLECULAR-STRUCTURE ON THE PARACELLULAR ROUTE OF GASTROINTESTINAL DRUG UPTAKE, Amino acids, 12(2), 1997, pp. 185-189
SYNTHESIS AND COMPARATIVE CONFORMATIONAL ENERGETICS OF D-PHENYLALANYLSARCOSINE AND ITS CYCLIC DEHYDRATION PRODUCT, (R)-1-METHYL-3-(PHENYLMETHYL)-2,5-PIPERAZINEDIONE
Authors: SPEERS P CHAN C WILCOCK R DOUGLAS KT
Citation: P. Speers et al., SYNTHESIS AND COMPARATIVE CONFORMATIONAL ENERGETICS OF D-PHENYLALANYLSARCOSINE AND ITS CYCLIC DEHYDRATION PRODUCT, (R)-1-METHYL-3-(PHENYLMETHYL)-2,5-PIPERAZINEDIONE, Amino acids, 12(1), 1997, pp. 49-56
STRUCTURAL STUDIES BY HIGH-FIELD NMR-SPECTROSCOPY OF A BINARY-ADDRESSED COMPLEMENTARY OLIGONUCLEOTIDE SYSTEM JUXTAPOSING PYRENE AND PERFLUORO-AZIDE UNITS
Authors: BICHENKOVA EV MARKS DS LOKHOV SG DOBRIKOV MI VLASSOV VV DOUGLAS KT
Citation: Ev. Bichenkova et al., STRUCTURAL STUDIES BY HIGH-FIELD NMR-SPECTROSCOPY OF A BINARY-ADDRESSED COMPLEMENTARY OLIGONUCLEOTIDE SYSTEM JUXTAPOSING PYRENE AND PERFLUORO-AZIDE UNITS, Journal of biomolecular structure & dynamics, 15(2), 1997, pp. 307-320
THE POTENTIAL ROLE OF GLYCINE-160 OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN REACTION WITH O-6-BENZYLGUANINE AS DETERMINED BY SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING COMPARISONS
Authors: RAFFERTY JA WIBLEY JEA SPEERS P HICKSON I MARGISON GP MOODY PCE DOUGLAS KT
Citation: Ja. Rafferty et al., THE POTENTIAL ROLE OF GLYCINE-160 OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN REACTION WITH O-6-BENZYLGUANINE AS DETERMINED BY SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING COMPARISONS, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1342(1), 1997, pp. 90-102
FLUPHENAZINE PHOTOAFFINITY-LABELING OF BINDING-SITES FOR PHENOTHIAZINE INHIBITORS OF TRYPANOTHIONE REDUCTASE
Authors: YIN H CHAN C GARFORTH J DOUGLAS KT BOLGAR MS GASKELL SJ FAIRLAMB AH
Citation: H. Yin et al., FLUPHENAZINE PHOTOAFFINITY-LABELING OF BINDING-SITES FOR PHENOTHIAZINE INHIBITORS OF TRYPANOTHIONE REDUCTASE, Chemical communications, (8), 1996, pp. 973-974
ORAL ABSORPTION OF D-OLIGOPEPTIDES IN RATS VIA THE PARACELLULAR ROUTE
Authors: HE YL MURBY S GIFFORD L COLLETT A WARHURST G DOUGLAS KT ROWLAND M AYRTON J
Citation: Yl. He et al., ORAL ABSORPTION OF D-OLIGOPEPTIDES IN RATS VIA THE PARACELLULAR ROUTE, Pharmaceutical research, 13(11), 1996, pp. 1673-1678
A COMMON CHEMICAL MECHANISM USED FOR DNA CLEAVAGE BY COPPER(II) ACTIVATED BY THIOLS AND ASCORBATE IS DISTINCT FROM THAT FOR COPPER(II)-HYDROGEN PEROXIDE CLEAVAGE
Authors: JOHN DCA DOUGLAS KT
Citation: Dca. John et Kt. Douglas, A COMMON CHEMICAL MECHANISM USED FOR DNA CLEAVAGE BY COPPER(II) ACTIVATED BY THIOLS AND ASCORBATE IS DISTINCT FROM THAT FOR COPPER(II)-HYDROGEN PEROXIDE CLEAVAGE, Transition metal chemistry, 21(5), 1996, pp. 460-463
A NOVEL CONVENIENT ROUTE TO THE NATURALLY-OCCURRING 3-OXOACYL-L-HOMOSERINELACTONES AND RELATED BACTERIAL AUTOINDUCERS
Authors: DEKHANE M DOUGLAS KT GILBERT P
Citation: M. Dekhane et al., A NOVEL CONVENIENT ROUTE TO THE NATURALLY-OCCURRING 3-OXOACYL-L-HOMOSERINELACTONES AND RELATED BACTERIAL AUTOINDUCERS, Tetrahedron letters, 37(11), 1996, pp. 1883-1884
SYNTHESIS OF SYMMETRICAL DISULFIDES AS POTENTIAL ALTERNATIVE SUBSTRATES FOR TRYPANOTHIONE REDUCTASE AND GLUTATHIONE-REDUCTASE .1.
Authors: JAOUHARI R BESHEYA T MCKIE JH DOUGLAS KT
Citation: R. Jaouhari et al., SYNTHESIS OF SYMMETRICAL DISULFIDES AS POTENTIAL ALTERNATIVE SUBSTRATES FOR TRYPANOTHIONE REDUCTASE AND GLUTATHIONE-REDUCTASE .1., Amino acids, 9(4), 1995, pp. 327-342
SYNTHESIS OF ASYMMETRIC DISULFIDES AS POTENTIAL ALTERNATIVE SUBSTRATES FOR TRYPANOTHIONE REDUCTASE AND GLUTATHIONE-REDUCTASE .2.
Authors: JAOUHARI R BESHEYA T MCKIE JH DOUGLAS KT
Citation: R. Jaouhari et al., SYNTHESIS OF ASYMMETRIC DISULFIDES AS POTENTIAL ALTERNATIVE SUBSTRATES FOR TRYPANOTHIONE REDUCTASE AND GLUTATHIONE-REDUCTASE .2., Amino acids, 9(4), 1995, pp. 343-351
INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL DRUGS
Authors: CHAN C YIN H GARFORTH J MCKIE JH JAOUHARI RA DOUGLAS KT FAIRLAMB AH CROFT SL
Citation: C. Chan et al., INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL DRUGS, Biochemical Society transactions, 23(4), 1995, pp. 511-511
SYNTHESIS, DNA-BINDING, FOOTPRINTING AND IN-VITRO ANTITUMOR STUDIES OF A META-HYDROXY ANALOG OF HOECHST-33258
Authors: EBRAHIMI SES BIBBY MC FOX KR DOUGLAS KT
Citation: Ses. Ebrahimi et al., SYNTHESIS, DNA-BINDING, FOOTPRINTING AND IN-VITRO ANTITUMOR STUDIES OF A META-HYDROXY ANALOG OF HOECHST-33258, Anti-cancer drug design, 10(6), 1995, pp. 463-479
A HOMOLOGY MODEL OF THE 3-DIMENSIONAL STRUCTURE OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BASED ON THE CRYSTAL-STRUCTURE OF THE C-TERMINAL DOMAIN OF THE ADA PROTEIN FROM ESCHERICHIA-COLI (VOL 10, PG 75, 1995)
Authors: WIBLEY JEA MCKIE JH EMBREY K MARKS DS DOUGLAS KT MOORE MH MOODY PCE
Citation: Jea. Wibley et al., A HOMOLOGY MODEL OF THE 3-DIMENSIONAL STRUCTURE OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BASED ON THE CRYSTAL-STRUCTURE OF THE C-TERMINAL DOMAIN OF THE ADA PROTEIN FROM ESCHERICHIA-COLI (VOL 10, PG 75, 1995), Anti-cancer drug design, 10(5), 1995, pp. 439-439
A HOMOLOGY MODEL OF THE 3-DIMENSIONAL STRUCTURE OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BASED ON THE CRYSTAL-STRUCTURE OF THE C-TERMINAL DOMAIN OF THE ADA PROTEIN FROM ESCHERICHIA-COLI
Authors: WIBLEY JEA MCKIE JH EMBREY K MARKS DS DOUGLAS KT MOORE MH MOODY PCE
Citation: Jea. Wibley et al., A HOMOLOGY MODEL OF THE 3-DIMENSIONAL STRUCTURE OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BASED ON THE CRYSTAL-STRUCTURE OF THE C-TERMINAL DOMAIN OF THE ADA PROTEIN FROM ESCHERICHIA-COLI, Anti-cancer drug design, 10(1), 1995, pp. 75-95
PREDICTABILITY OF DESIGNING SPECIFIC BINDING INTERACTIONS FOR DNA MINOR-GROOVE LIGANDS FROM NMR-SPECTROSCOPY AND MOLECULAR MODELING - A COPPER(II)-ACTIVATED DNA CLEAVER BASED ON HOECHST-33258
Authors: PARKINSON J SADATEBRAHIMI S WILTON A MCKIE JH ANDREWS J DOUGLAS KT
Citation: J. Parkinson et al., PREDICTABILITY OF DESIGNING SPECIFIC BINDING INTERACTIONS FOR DNA MINOR-GROOVE LIGANDS FROM NMR-SPECTROSCOPY AND MOLECULAR MODELING - A COPPER(II)-ACTIVATED DNA CLEAVER BASED ON HOECHST-33258, Biochemistry, 34(50), 1995, pp. 16240-16244
SITE-DIRECTED MUTAGENESIS OF A SERINE RESIDUE IN CINNAMYL ALCOHOL-DEHYDROGENASE, A PLANT NADPH-DEPENDENT DEHYDROGENASE, AFFECTS THE SPECIFICITY FOR THE COENZYME
Authors: LAUVERGEAT V KENNEDY K FEUILLET C MCKIE JH GORRICHON L BALTAS M BOUDET AM GRIMAPETTENATI J DOUGLAS KT
Citation: V. Lauvergeat et al., SITE-DIRECTED MUTAGENESIS OF A SERINE RESIDUE IN CINNAMYL ALCOHOL-DEHYDROGENASE, A PLANT NADPH-DEPENDENT DEHYDROGENASE, AFFECTS THE SPECIFICITY FOR THE COENZYME, Biochemistry, 34(38), 1995, pp. 12426-12434
RATIONAL DESIGN OF PEPTIDE-BASED INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL DRUGS
Authors: GARFORTH J MCKIE JH JAOUHARI R BENSON TJ FAIRLAMB AH DOUGLAS KT
Citation: J. Garforth et al., RATIONAL DESIGN OF PEPTIDE-BASED INHIBITORS OF TRYPANOTHIONE REDUCTASE AS POTENTIAL ANTITRYPANOSOMAL DRUGS, Amino acids, 6(3), 1994, pp. 295-299
INHIBITION OF TUMOR GLYOXALASE I BY SUBSTITUTED GLUTATHIONES AND HYDROXY-QUINONE (AND ANALOGOUS) COMPOUNDS
Authors: DOUGLAS KT KEYWORTH LTA
Citation: Kt. Douglas et Lta. Keyworth, INHIBITION OF TUMOR GLYOXALASE I BY SUBSTITUTED GLUTATHIONES AND HYDROXY-QUINONE (AND ANALOGOUS) COMPOUNDS, Medical science research, 22(9), 1994, pp. 641-642
Risultati: 1-25 | 26-34