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Results: 1-22 |
Results: 22
Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: Variation ofthe delta address and its effects on affinity and selectivity for the delta opioid receptor
Authors: Ulrich, T Dersch, CM Rothman, RB Jacobson, AE Rice, KC
Citation: T. Ulrich et al., Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: Variation ofthe delta address and its effects on affinity and selectivity for the delta opioid receptor, BIOORG MED, 11(21), 2001, pp. 2883-2885
1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain
Authors: Baumann, MH Ayestas, MA Dersch, CM Rothman, RB
Citation: Mh. Baumann et al., 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain, NEUROPSYCH, 24(5), 2001, pp. 492-501
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
Authors: Rothman, RB Baumann, MH Dersch, CM Romero, DV Rice, KC Carroll, FI Partilla, JS
Citation: Rb. Rothman et al., Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin, SYNAPSE, 39(1), 2001, pp. 32-41
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl) arylamino]-N,N-diethylbenzamides
Authors: Thomas, JB Herault, XM Rothman, RB Atkinson, RN Burgess, JP Mascarella, SW Dersch, CM Xu, H Flippen-Anderson, JL George, CF Carroll, FI
Citation: Jb. Thomas et al., Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl) arylamino]-N,N-diethylbenzamides, J MED CHEM, 44(6), 2001, pp. 972-987
Synthesis and biological evaluation of tropane-like 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl) piperazine (GBR 12909) analogues
Authors: Zhang, Y Joseph, DB Bowen, WD Flippen-Anderson, JL Dersch, CM Rothman, RB Jacobson, AE Rice, KC
Citation: Y. Zhang et al., Synthesis and biological evaluation of tropane-like 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl) piperazine (GBR 12909) analogues, J MED CHEM, 44(23), 2001, pp. 3937-3945
Identification of the first trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity
Authors: Thomas, JB Atkinson, RN Rothman, RB Fix, SE Mascarella, SW Vinson, NA Xu, H Dersch, CM Lu, YF Cantrell, BE Zimmerman, DM Carroll, FI
Citation: Jb. Thomas et al., Identification of the first trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity, J MED CHEM, 44(17), 2001, pp. 2687-2690
Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters
Authors: Yu, H Rothman, RB Dersch, CM Partilla, JS Rice, KC
Citation: H. Yu et al., Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters, BIO MED CH, 8(12), 2000, pp. 2689-2692
4-[(8-alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: High affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity
Authors: Thomas, JB Atkinson, RN Rothman, RB Burgess, JP Mascarella, SW Dersch, CM Xu, H Carroll, FI
Citation: Jb. Thomas et al., 4-[(8-alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: High affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity, BIOORG MED, 10(11), 2000, pp. 1281-1284
Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: Therapeutic implications
Authors: Baumann, MH Ayestas, MA Dersch, CM Brockington, A Rice, KC Rothman, RB
Citation: Mh. Baumann et al., Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: Therapeutic implications, SYNAPSE, 36(2), 2000, pp. 102-113
Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: A pharmacological strategyfor treating stimulant abuse
Authors: Rothman, RB Partilla, JS Baumann, MH Dersch, CM Carroll, FI Rice, KC
Citation: Rb. Rothman et al., Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: A pharmacological strategyfor treating stimulant abuse, SYNAPSE, 35(3), 2000, pp. 222-227
Neurochemical neutralization of amphetamine-type stimulants in rat brain by the indatraline analog (-)-HY038
Authors: Partilla, JS Dersch, CM Yu, H Rice, KC Rothman, RB
Citation: Js. Partilla et al., Neurochemical neutralization of amphetamine-type stimulants in rat brain by the indatraline analog (-)-HY038, BRAIN RES B, 53(6), 2000, pp. 821-826
Synthesis and transporter binding properties of bridged piperazine analogues of 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine (GBR 12909)
Authors: Zhang, Y Rothman, RB Dersch, CM de Costa, BR Jacobson, AE Rice, KC
Citation: Y. Zhang et al., Synthesis and transporter binding properties of bridged piperazine analogues of 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine (GBR 12909), J MED CHEM, 43(25), 2000, pp. 4840-4849
Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline
Authors: Gu, XH Yu, H Jacobson, AE Rothman, RB Dersch, CM George, C Flippen-Anderson, JL Rice, KC
Citation: Xh. Gu et al., Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline, J MED CHEM, 43(25), 2000, pp. 4868-4876
Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alpha R)-alpha-(2S,5R)-4-substituted-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers
Authors: Furness, MS Zhang, XY Coop, A Jacobson, AE Rothman, RB Dersch, CM Xu, H Porreca, F Rice, KC
Citation: Ms. Furness et al., Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alpha R)-alpha-(2S,5R)-4-substituted-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers, J MED CHEM, 43(16), 2000, pp. 3193-3196
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzamide displays selective binding and full agonist activity for thedelta opioid receptor
Authors: Thomas, JB Atkinson, RN Herault, XM Rothman, RB Mascarella, SW Dersch, CM Xu, H Horel, RB Carroll, FI
Citation: Jb. Thomas et al., Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzamide displays selective binding and full agonist activity for thedelta opioid receptor, BIOORG MED, 9(23), 1999, pp. 3347-3350
(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opiod receptor
Authors: Thomas, JB Herault, XM Rothman, RB Burgess, JP Mascarella, SW Xu, H Horel, RB Dersch, CM Carroll, FI
Citation: Jb. Thomas et al., (+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opiod receptor, BIOORG MED, 9(20), 1999, pp. 3053-3056
Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library
Authors: Rothman, RB Baumann, MH Dersch, CM Appel, J Houghten, RA
Citation: Rb. Rothman et al., Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library, SYNAPSE, 33(3), 1999, pp. 239-246
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands
Authors: Zhang, XY Rice, KC Calderon, SN Kayakiri, H Smith, L Coop, A Jacobson, AE Rothman, RB Davis, P Dersch, CM Porreca, F
Citation: Xy. Zhang et al., Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands, J MED CHEM, 42(26), 1999, pp. 5455-5463
Oxygenated analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents
Authors: Lewis, DB Matecka, D Zhang, Y Hsin, LW Dersch, CM Stafford, D Glowa, JR Rothman, RB Rice, KC
Citation: Db. Lewis et al., Oxygenated analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents, J MED CHEM, 42(24), 1999, pp. 5029-5042
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans
Authors: Ananthan, S Kezar, HS Carter, RL Saini, SK Rice, KC Wells, JL Davis, P Xu, H Dersch, CM Bilsky, EJ Porreca, F Rothman, RB
Citation: S. Ananthan et al., Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans, J MED CHEM, 42(18), 1999, pp. 3527-3538
Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates - Implications for primary pulmonary hypertension
Authors: Rothman, RB Ayestas, MA Dersch, CM Baumann, MH
Citation: Rb. Rothman et al., Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates - Implications for primary pulmonary hypertension, CIRCULATION, 100(8), 1999, pp. 869-875
Identification of an opioid kappa receptor subtype-selective N-substituentfor (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine
Authors: Thomas, JB Fall, MJ Cooper, JB Rothman, RB Mascarella, SW Xu, H Partilla, JS Dersch, CM McCullough, KB Cantrell, BE Zimmerman, DM Carroll, FI
Citation: Jb. Thomas et al., Identification of an opioid kappa receptor subtype-selective N-substituentfor (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine, J MED CHEM, 41(26), 1998, pp. 5188-5197
Risultati: 1-22 |