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Results: 1-16 |
Results: 16
3,8-diazabicyclo[3.2.1]octan-2-one peptide mimetics: Synthesis of a conformationally restricted inhibitor of farnesyltransferase
Authors: Dinsmore, CJ Bergman, JM Bogusky, MJ Culterson, JC Hamilton, KA Graham, SL
Citation: Cj. Dinsmore et al., 3,8-diazabicyclo[3.2.1]octan-2-one peptide mimetics: Synthesis of a conformationally restricted inhibitor of farnesyltransferase, ORG LETT, 3(6), 2001, pp. 865-868
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase
Authors: Trotter, BW Quigley, AG Lumma, WC Sisko, JT Walsh, ES Hamann, CS Robinson, RG Bhimnathwala, H Kolodin, DG Zheng, W Buser, CA Huber, HE Lobell, RB Kohl, NE Williams, TM Graham, SL Dinsmore, CJ
Citation: Bw. Trotter et al., 2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase, BIOORG MED, 11(7), 2001, pp. 865-869
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase
Authors: Dinsmore, CJ Bergman, JM Wei, DD Zartman, CB Davide, JP Greenberg, IB Liu, DM O'Neill, TJ Gibbs, JB Koblan, KS Kohl, NE Lobell, RB Chen, IW McLoughlin, DA Olah, TV Graham, SL Hartman, GD Williams, TM
Citation: Cj. Dinsmore et al., Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase, BIOORG MED, 11(4), 2001, pp. 537-540
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors offarnesyl-protein transferase
Authors: Beshore, DC Bell, IM Dinsmore, CJ Homnick, CF Culberson, JC Robinson, RG Fernandes, C Walsh, ES Abrams, MT Bhimnathwala, HG Davide, JP Ellis-Hutchings, MS Huber, HA Koblan, KS Buser, CA Kohl, NE Lobell, RB Chen, IW McLoughlin, DA Olah, TV Graham, SL Hartman, GD Williams, TM
Citation: Dc. Beshore et al., Evaluation of amino acid-based linkers in potent macrocyclic inhibitors offarnesyl-protein transferase, BIOORG MED, 11(14), 2001, pp. 1817-1821
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Authors: Bergman, JM Abrams, MT Davide, JP Greenberg, IB Robinson, RG Buser, CA Huber, HE Koblan, KS Kohl, NE Lobell, RB Graham, SL Hartman, GD Williams, TM Dinsmore, CJ
Citation: Jm. Bergman et al., Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I, BIOORG MED, 11(11), 2001, pp. 1411-1415
Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors
Authors: Huber, HE Robinson, RG Watkins, A Nahas, DD Abrams, MT Buser, CA Lobell, RB Patrick, D Anthony, NJ Dinsmore, CJ Graham, SL Hartman, GD Lumma, WC Williams, TM Heimbrook, DC
Citation: He. Huber et al., Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors, J BIOL CHEM, 276(27), 2001, pp. 24457-24465
P450 interaction with farnesyl-protein transferase inhibitors - Metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes
Authors: Chiba, M Tang, CY Neway, WE Williams, TM Desolms, SJ Dinsmore, CJ Wai, JS Lin, JH
Citation: M. Chiba et al., P450 interaction with farnesyl-protein transferase inhibitors - Metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes, BIOCH PHARM, 62(6), 2001, pp. 773-776
High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123
Authors: Buser, CA Dinsmore, CJ Fernandes, C Greenberg, I Hamilton, K Mosser, SD Walsh, ES Williams, TM Koblan, KS
Citation: Ca. Buser et al., High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123, ANALYT BIOC, 290(1), 2001, pp. 126-137
Conformational restriction of flexible ligands guided by the transferred NOE experiment: Potent macrocyclic inhibitors of farnesyltransferase
Authors: Dinsmore, CJ Bogusky, MJ Culberson, JC Bergman, JM Homnick, CF Zartman, CB Mosser, SD Schaber, MD Robinson, RG Koblan, KS Huber, HE Graham, SL Hartman, GD Huff, JR Williams, TM
Citation: Cj. Dinsmore et al., Conformational restriction of flexible ligands guided by the transferred NOE experiment: Potent macrocyclic inhibitors of farnesyltransferase, J AM CHEM S, 123(9), 2001, pp. 2107-2108
Synthesis of conformationally constrained 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine inhibitors of farnesyltransferase
Authors: Dinsmore, CJ Zartman, CB Baginsky, WF O'Neill, TJ Koblan, KS Chen, IW Mcloughlin, DA Olah, TV Huff, JR
Citation: Cj. Dinsmore et al., Synthesis of conformationally constrained 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine inhibitors of farnesyltransferase, ORG LETT, 2(22), 2000, pp. 3473-3476
Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization
Authors: Beshore, DC Dinsmore, CJ
Citation: Dc. Beshore et Cj. Dinsmore, Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization, TETRAHEDR L, 41(45), 2000, pp. 8735-8739
Efficient synthesis of substituted piperazinones via tandem reductive amination-cyclization
Authors: Dinsmore, CJ Zartman, CB
Citation: Cj. Dinsmore et Cb. Zartman, Efficient synthesis of substituted piperazinones via tandem reductive amination-cyclization, TETRAHEDR L, 41(33), 2000, pp. 6309-6312
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
Authors: Dinsmore, CJ Williams, TM O'Neill, TJ Liu, DM Rands, E Culberson, JC Lobell, RB Koblan, KS Kohl, NE Gibbs, JB Oliff, AI Graham, SL Hartman, GD
Citation: Cj. Dinsmore et al., Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase, BIOORG MED, 9(23), 1999, pp. 3301-3306
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase
Authors: Ciccarone, TM MacTough, SC Williams, TM Dinsmore, CJ O'Neill, TJ Shah, D Culberson, JC Koblan, KS Kohl, NE Gibbs, JB Oliff, AI Graham, SL Hartman, GD
Citation: Tm. Ciccarone et al., Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase, BIOORG MED, 9(14), 1999, pp. 1991-1996
Arylmethanesulfonates are convenient latent phenols in the nucleophilic aromatic substitution reaction
Authors: Dinsmore, CJ Zartman, CB
Citation: Cj. Dinsmore et Cb. Zartman, Arylmethanesulfonates are convenient latent phenols in the nucleophilic aromatic substitution reaction, TETRAHEDR L, 40(21), 1999, pp. 3989-3990
N-arylpiperazinone inhibitors of farnesyltransferase: Discovery and biological activity
Authors: Williams, TM Bergman, JM Brashear, K Breslin, MJ Dinsmore, CJ Hutchinson, JH MacTough, SC Stump, CA Wei, DD Zartman, CB Bogusky, MJ Culberson, JC Buser-Doepner, C Davide, J Greenberg, IB Hamilton, KA Koblan, KS Kohl, NE Liu, DM Lobell, RB Mosser, SD O'Neill, TJ Rands, E Schaber, MD Wilson, F Senderak, E Motzel, SL Gibbs, JB Graham, SL Heimbrook, DC Hartman, GD Oliff, AI Huff, JR
Citation: Tm. Williams et al., N-arylpiperazinone inhibitors of farnesyltransferase: Discovery and biological activity, J MED CHEM, 42(19), 1999, pp. 3779-3784
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