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Results: 21
Authors:
McFadyen, MCE
McLeod, HL
Jackson, FC
Melvin, WT
Doehmer, J
Murray, GI
Citation: Mce. Mcfadyen et al., Cytochrome P450CYP1B1 protein expression: a novel mechanism of anticancer drug resistance, BIOCH PHARM, 62(2), 2001, pp. 207-212
Authors:
Luch, A
Schober, W
Greim, H
Doehmer, J
Jacob, J
Seidel, A
Baird, WM
Citation: A. Luch et al., Metabolic activation of dibenzo[a,l]pyrene by cytochrome P450 enzymes to stable DNA adducts occurs exclusively through the formation of the (-)-trans-(11R,12R)-diol, POLYCYCL AR, 21(1-4), 2000, pp. 87-98
Authors:
Jacob, J
Raab, G
Schober, W
Frank, H
Luch, A
Doehmer, J
Seidel, A
Citation: J. Jacob et al., Species-dependent metabolism of benzo[c]chrysene mediated by C-DNA-expressed human, rodent and fish cytochrome P450 enzymes, POLYCYCL AR, 21(1-4), 2000, pp. 109-121
Authors:
Thatcher, NJ
Edwards, RJ
Lemoine, NR
Doehmer, J
Davies, DS
Citation: Nj. Thatcher et al., The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy, CANC GENE T, 7(4), 2000, pp. 521-525
Authors:
Dayal, M
Parmar, D
Dhawan, A
Dwivedi, UN
Doehmer, J
Seth, PK
Citation: M. Dayal et al., Induction of rat brain and liver cytochrome P450 1A1/1A2 and 2B1/2B2 isoenzymes by deltamethrin, ENV TOX PH, 7(3), 1999, pp. 169-178
Authors:
Luch, A
Coffing, SL
Seidel, A
Greim, H
Baird, WM
Doehmer, J
Citation: A. Luch et al., DNA modification induced after metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in V79 Chinese hamster cells stably expressing singlecytochromes P450, POLYCYCL AR, 16(1-4), 1999, pp. 71-78
Authors:
Jacob, J
Raab, G
Soballa, VJ
Luch, A
Grimmer, G
Greim, H
Doehmer, J
Morrison, HG
Stegeman, JJ
Seidel, A
Citation: J. Jacob et al., Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,l]pyrene by various CYP450 isoforms, POLYCYCL AR, 16(1-4), 1999, pp. 191-203
Authors:
Doehmer, J
Krebsfanger, N
Schober, W
Luch, A
Buters, JTM
Citation: J. Doehmer et al., The establishment of the V79 cell battery and its application in toxicology and pharmacology, ALTEX-AL TI, 16(3), 1999, pp. 180-181
Authors:
Luch, A
Schober, W
Soballa, VJ
Raab, G
Greim, H
Jacob, J
Doehmer, J
Seidel, A
Citation: A. Luch et al., Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells, CHEM RES T, 12(4), 1999, pp. 353-364
Authors:
Gebhardt, R
Lippert, C
Schneider, A
Doehmer, J
Citation: R. Gebhardt et al., Improved determination of drug metabolism by perifusion of recombinant V79cells carrying human CYP3A4, TOX VITRO, 13(4-5), 1999, pp. 639-643
Authors:
Doehmer, J
Buters, JTM
Luch, A
Soballa, V
Baird, WM
Morisson, H
Stegeman, JJ
Townsend, AJ
Greenlee, WF
Glatt, HR
Seidel, A
Jacob, J
Greim, H
Citation: J. Doehmer et al., Molecular studies on the toxifying effects by genetically engineered cytochromes P450, DRUG METAB, 31(2), 1999, pp. 423-435
Authors:
Buters, JTM
Doehmer, J
Gonzalez, FJ
Citation: Jtm. Buters et al., Cytochrome P450-null mice, DRUG METAB, 31(2), 1999, pp. 437-447
Authors:
Townsend, AJ
Fields, WR
Doss, AJ
Clapper, ML
Doehmer, J
Morrow, CS
Citation: Aj. Townsend et al., Modeling the chemoprotective functions of glutathione S-transferases in cultured cell lines by heterologous expression, DRUG METAB, 31(1), 1999, pp. 43-69
Authors:
Philip, PA
Ali-Sadat, S
Doehmer, J
Kocarek, T
Akhtar, A
Lu, H
Chan, KK
Citation: Pa. Philip et al., Use of V79 cells with stably transfected cytochrome P450 cDNAs in studyingthe metabolism and effects of cytotoxic drugs, CANC CHEMOT, 43(1), 1999, pp. 59-67
Authors:
Simi, S
Xiao, Y
Campagna, M
Doehmer, J
Darroudi, F
Citation: S. Simi et al., Dual-colour FISH analysis to characterize a marker chromosome in cytochrome P450 2B1 recombinant V79 Chinese hamster cells, MUTAGENESIS, 14(1), 1999, pp. 57-61
Authors:
Coecke, S
Rogiers, V
Bayliss, M
Castell, J
Doehmer, J
Fabre, G
Fry, J
Kern, A
Westmoreland, C
Citation: S. Coecke et al., The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes: The current status - ECVAM hepatocytes and metabolically competent systems task force report 1, ATLA-ALT L, 27(4), 1999, pp. 579-638
Authors:
Engst, W
Landsiedel, R
Hermersdorfer, H
Doehmer, J
Glatt, H
Citation: W. Engst et al., Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells, CARCINOGENE, 20(9), 1999, pp. 1777-1785
Authors:
Fields, WR
Morrow, CS
Doehmer, J
Townsend, AJ
Citation: Wr. Fields et al., Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B-1 in hamster V79 cells expressing rat cytochrome P450-2B1, CARCINOGENE, 20(6), 1999, pp. 1121-1125
Authors:
Luch, A
Kudla, K
Seidel, A
Doehmer, J
Greim, H
Baird, WM
Citation: A. Luch et al., The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21(WAF1) in the human mammary carcinoma cell line MCF-7, CARCINOGENE, 20(5), 1999, pp. 859-865
Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas
Authors:
Buters, JTM
Sakai, S
Richter, T
Pineau, T
Alexander, DL
Savas, U
Doehmer, J
Ward, JM
Jefcoate, CR
Gonzalez, FJ
Citation: Jtm. Buters et al., Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas, P NAS US, 96(5), 1999, pp. 1977-1982
Authors:
Luch, A
Kishiyama, S
Seidel, A
Doehmer, J
Greim, H
Baird, WM
Citation: A. Luch et al., The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1, CANCER RES, 59(18), 1999, pp. 4603-4609
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