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Results: 1-13 |
Results: 13
Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase
Authors: Lee, CC Medrano, FJ Craig, SP Eakin, AE
Citation: Cc. Lee et al., Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase, BBA-MOL BAS, 1537(1), 2001, pp. 63-70
Induction of Tmolt(4) leukemia cell death by 3,3-disubstituted-6,6-pentamethylene-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: Specificity for type II inosine 5 '-monophosphate dehydrogenase
Authors: Barnes, BJ Izydore, RA Eakin, AE Hall, IH
Citation: Bj. Barnes et al., Induction of Tmolt(4) leukemia cell death by 3,3-disubstituted-6,6-pentamethylene-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: Specificity for type II inosine 5 '-monophosphate dehydrogenase, J PHARM EXP, 298(2), 2001, pp. 790-796
Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: Potent inhibitors of human type II inosine 5 '-monophosphate dehydrogenase
Authors: Barnes, BJ Izydore, RA Eakin, AE Hall, IH
Citation: Bj. Barnes et al., Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: Potent inhibitors of human type II inosine 5 '-monophosphate dehydrogenase, INT J CANC, 94(2), 2001, pp. 275-281
The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, andX-ray crystallography
Authors: Canyuk, B Focia, PJ Eakin, AE
Citation: B. Canyuk et al., The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, andX-ray crystallography, BIOCHEM, 40(9), 2001, pp. 2754-2765
Implications of selective type IIIMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death
Authors: Barnes, BJ Eakin, AE Izydore, RA Hall, IH
Citation: Bj. Barnes et al., Implications of selective type IIIMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death, BIOCH PHARM, 62(1), 2001, pp. 91-100
Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi
Authors: Freymann, DM Wenck, MA Engel, JC Feng, J Focia, PJ Eakin, AE Craig, SP
Citation: Dm. Freymann et al., Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi, CHEM BIOL, 7(12), 2000, pp. 957-968
Structure-based inhibitor design
Authors: Craig, SP Eakin, AE
Citation: Sp. Craig et Ae. Eakin, Structure-based inhibitor design, VITAM HORM, 58, 2000, pp. 149
Purine phosphoribosyltransferases
Authors: Craig, SP Eakin, AE
Citation: Sp. Craig et Ae. Eakin, Purine phosphoribosyltransferases, J BIOL CHEM, 275(27), 2000, pp. 20231-20234
Selective inhibition of human molt-4 leukemia type II inosine 5 '-monophosphate dehydrogenase by the 1,5-diazabicyclo[3.1.0]hexane-2,4-diones
Authors: Barnes, BJ Eakin, AE Izydore, RA Hall, IH
Citation: Bj. Barnes et al., Selective inhibition of human molt-4 leukemia type II inosine 5 '-monophosphate dehydrogenase by the 1,5-diazabicyclo[3.1.0]hexane-2,4-diones, BIOCHEM, 39(45), 2000, pp. 13641-13650
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitorHPP reveals the involvement of the flexible loop in substrate binding
Authors: Balendiran, GK Molina, JA Xu, YM Torres-Martinez, J Stevens, R Focia, PJ Eakin, AE Sacchettini, JC Craig, SP
Citation: Gk. Balendiran et al., Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitorHPP reveals the involvement of the flexible loop in substrate binding, PROTEIN SCI, 8(5), 1999, pp. 1023-1031
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitorHPP reveals the involvement of the flexible loop in substrate binding (vol8, pg 1023, 1999)
Authors: Balendiran, GK Molina, JA Xu, YM Torres-Martinez, J Stevens, R Focia, PJ Eakin, AE Sacchettini, JC Craig, SP
Citation: Gk. Balendiran et al., Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitorHPP reveals the involvement of the flexible loop in substrate binding (vol8, pg 1023, 1999), PROTEIN SCI, 8(12), 1999, pp. 2815-2815
Determinants of phencyclidine potency on the nicotinic acetylcholine receptors from muscle and electric organ
Authors: Eterovic, VA Lu, RL Eakin, AE Rodriguez, AD Ferchmin, PA
Citation: Va. Eterovic et al., Determinants of phencyclidine potency on the nicotinic acetylcholine receptors from muscle and electric organ, CELL MOL N, 19(6), 1999, pp. 745-757
Approaching the transition state in the crystal structure of a phosphoribosyltransferase
Authors: Focia, PJ Craig, SP Eakin, AE
Citation: Pj. Focia et al., Approaching the transition state in the crystal structure of a phosphoribosyltransferase, BIOCHEM, 37(49), 1998, pp. 17120-17127
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