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Results: 1-7 |
Results: 7
The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N-alpha-(4-amino-4-deoxypteroyl)-N-delta-hemiphthaloyl-L-ornithine
Authors: Rosowsky, A Wright, JE Vaidya, CM Forsch, RA
Citation: A. Rosowsky et al., The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N-alpha-(4-amino-4-deoxypteroyl)-N-delta-hemiphthaloyl-L-ornithine, PHARM THERA, 85(3), 2000, pp. 191-205
Analogues of the potent nonpolyglutamatable antifolate N-alpha-(4-amino-4-deoxypteroyl)-N-delta-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: Synthesis and in vitro antitumor activity
Authors: Rosowsky, A Wright, JE Vaidya, CM Forsch, RA Bader, H
Citation: A. Rosowsky et al., Analogues of the potent nonpolyglutamatable antifolate N-alpha-(4-amino-4-deoxypteroyl)-N-delta-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: Synthesis and in vitro antitumor activity, J MED CHEM, 43(8), 2000, pp. 1620-1634
Synthesis of the gamma-sulfinic acid and gamma-nitro analogues of 5-deazatetrahydrofolic acid
Authors: Forsch, RA Wright, JE Rosowsky, A
Citation: Ra. Forsch et al., Synthesis of the gamma-sulfinic acid and gamma-nitro analogues of 5-deazatetrahydrofolic acid, HETEROCYCLE, 51(8), 1999, pp. 1789-1805
Synthesis of gamma-[N-15]-L-glutamyl derivatives of 5,10-dideazatetrahydrofolate
Authors: Forsch, RA Rosowsky, A
Citation: Ra. Forsch et A. Rosowsky, Synthesis of gamma-[N-15]-L-glutamyl derivatives of 5,10-dideazatetrahydrofolate, J LABEL C R, 42(11), 1999, pp. 1103-1117
Synthesis and antiparasitic and antitumor activity of 2,4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim
Authors: Rosowsky, A Papoulis, AT Forsch, RA Queener, SF
Citation: A. Rosowsky et al., Synthesis and antiparasitic and antitumor activity of 2,4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim, J MED CHEM, 42(6), 1999, pp. 1007-1017
5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: Synthesis and binding interaction with folylpolyglutamate synthetase
Authors: Rosowsky, A Forsch, RA Null, A Moran, RG
Citation: A. Rosowsky et al., 5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: Synthesis and binding interaction with folylpolyglutamate synthetase, J MED CHEM, 42(18), 1999, pp. 3510-3519
Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor N-alpha-(4-amino-4-deoxypteroyl)-N-delta-hemiphthaloyl-L-ornithine (PT523)
Authors: Rosowsky, A Wright, JE Vaidya, CM Bader, H Forsch, RA Mota, CE Pardo, J Chen, CS Chen, YN
Citation: A. Rosowsky et al., Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor N-alpha-(4-amino-4-deoxypteroyl)-N-delta-hemiphthaloyl-L-ornithine (PT523), J MED CHEM, 41(26), 1998, pp. 5310-5319
Risultati: 1-7 |