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Citation: Ve. Anderson et al., TOPOISOMERASE-IV CATALYSIS AND THE MECHANISM OF QUINOLONE ACTION, The Journal of biological chemistry, 273(28), 1998, pp. 17879-17885
Authors:
DEKKER KA
INAGAKI T
GOOTZ TD
HUANG LH
KOJIMA Y
KOHLBRENNER WE
MATSUNAGA Y
MCGUIRK PR
NOMURA E
SAKAKIBARA T
SAKEMI S
SUZUKI Y
YAMAUCHI Y
KOJIMA N
Citation: Ka. Dekker et al., NEW QUINOLONE COMPOUNDS FROM PSEUDONOCARDIA SP. WITH SELECTIVE AND POTENT ANTI-HELICOBACTER PYLORI ACTIVITY - TAXONOMY OF PRODUCING STRAIN,FERMENTATION, ISOLATION, STRUCTURAL ELUCIDATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 51(2), 1998, pp. 145-152
Citation: Kp. Klugman et Td. Gootz, IN-VITRO AND IN-VIVO ACTIVITY OF TROVAFLOXACIN AGAINST STREPTOCOCCUS-PNEUMONIAE, Journal of antimicrobial chemotherapy, 39, 1997, pp. 51-55
Authors:
DEKKER KA
INAGAKI T
GOOTZ TD
KANEDA K
NOMURA E
SAKAKIBARA T
SAKEMI S
SUGIE Y
YAMAUCHI Y
YOSHIKAWA N
KOJIMA N
Citation: Ka. Dekker et al., CJ-12,954 AND ITS CONGENERS, NEW ANTI-HELICOBACTER PYLORI COMPOUNDS PRODUCED BY PHANEROCHAETE VELUTINA - FERMENTATION, ISOLATION, STRUCTURAL ELUCIDATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 50(10), 1997, pp. 833-839
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Authors:
TENG RL
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GOOTZ TD
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LISTON TE
Citation: Rl. Teng et al., PHARMACOKINETICS OF TROVAFLOXACIN (CP-99,219), A NEW QUINOLONE, IN RATS, DOGS, AND MONKEYS, Antimicrobial agents and chemotherapy, 40(3), 1996, pp. 561-566
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GOOTZ TD
ZANIEWSKI R
HASKELL S
SCHMIEDER B
TANKOVIC J
GIRARD D
COURVALIN P
POLZER RJ
Citation: Td. Gootz et al., ACTIVITY OF THE NEW FLUOROQUINOLONE TROVAFLOXACIN (CP-99,219) AGAINSTDNA GYRASE AND TOPOISOMERASE-IV MUTANTS OF STREPTOCOCCUS-PNEUMONIAE SELECTED IN-VITRO, Antimicrobial agents and chemotherapy, 40(12), 1996, pp. 2691-2697
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GIRARD AE
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GOOTZ TD
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CIMOCHOWSKI CR
Citation: Ae. Girard et al., IN-VIVO EFFICACY OF TROVAFLOXACIN (CP-99,219), A NEW QUINOLONE WITH EXTENDED ACTIVITIES AGAINST GRAM-POSITIVE PATHOGENS, STREPTOCOCCUS-PNEUMONIAE, AND BACTEROIDES-FRAGILIS, Antimicrobial agents and chemotherapy, 39(10), 1995, pp. 2210-2216
Authors:
SPITZNER JR
CHUNG IK
GOOTZ TD
MCGUIRK PR
MULLER MT
Citation: Jr. Spitzner et al., ANALYSIS OF EUKARYOTIC TOPOISOMERASE-II CLEAVAGE SITES IN THE PRESENCE OF THE QUINOLONE CP-115,953 REVEALS DRUG-DEPENDENT AND DRUG-INDEPENDENT RECOGNITION ELEMENTS, Molecular pharmacology, 48(2), 1995, pp. 238-249
Authors:
GOOTZ TD
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ANDERSON MR
SCHMIEDER BJ
HASKELL SL
SUTCLIFFE JA
CASTALDI MJ
MCGUIRK PR
Citation: Td. Gootz et al., IN-VITRO ACTIVITY OF CP-99,219, A NOVEL 7-(3-AZABICYCLO[3.1.0]HEXYL) NAPHTHYRIDONE ANTIMICROBIAL, Diagnostic microbiology and infectious disease, 19(4), 1994, pp. 235-243
Authors:
GOOTZ TD
MCGUIRK PR
MOYNIHAN MS
HASKELL SL
Citation: Td. Gootz et al., PLACEMENT OF ALKYL SUBSTITUENTS ON THE C-7 PIPERAZINE RING OF FLUOROQUINOLONES - DRAMATIC DIFFERENTIAL-EFFECTS ON MAMMALIAN TOPOISOMERASE-II AND DNA GYRASE, Antimicrobial agents and chemotherapy, 38(1), 1994, pp. 130-133
Authors:
GOOTZ TD
PEREZPEREZ GI
CLANCY J
MARTIN BA
TAITKAMRADT A
BLASER MJ
Citation: Td. Gootz et al., IMMUNOLOGICAL AND MOLECULAR CHARACTERIZATION OF HELICOBACTER-FELIS UREASE, Infection and immunity, 62(3), 1994, pp. 793-798
Authors:
ELSEA SH
MCGUIRK PR
GOOTZ TD
MOYNIHAN M
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Citation: Sh. Elsea et al., DRUG FEATURES THAT CONTRIBUTE TO THE ACTIVITY OF QUINOLONES AGAINST MAMMALIAN TOPOISOMERASE-II AND CULTURED-CELLS - CORRELATION BETWEEN ENHANCEMENT OF ENZYME-MEDIATED DNA CLEAVAGE IN-VITRO AND CYTOTOXIC POTENTIAL, Antimicrobial agents and chemotherapy, 37(10), 1993, pp. 2179-2186