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Results: 1-25 | 26-36 |
Results: 26-36/36
Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells usingO-6-benzylguanine and temozolomide
Authors: Reese, JS Davis, BM Liu, LL Gerson, SL
Citation: Js. Reese et al., Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells usingO-6-benzylguanine and temozolomide, CLIN CANC R, 5(1), 1999, pp. 163-169
Delta MGMT-transduced bone marrow infusion increases tolerance to O-6-benzylguanine and 1,3-bis(2-chloroethy1)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts
Authors: Koc, ON Reese, JS Davis, BM Liu, L Majczenko, KJ Gerson, SL
Citation: On. Koc et al., Delta MGMT-transduced bone marrow infusion increases tolerance to O-6-benzylguanine and 1,3-bis(2-chloroethy1)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts, HUM GENE TH, 10(6), 1999, pp. 1021-1030
Characterization of the P140K, PVP(138-140)MLK, and G156A O-6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy
Authors: Davis, BM Roth, JC Liu, LL Xu-Welliver, M Pegg, AE Gerson, SL
Citation: Bm. Davis et al., Characterization of the P140K, PVP(138-140)MLK, and G156A O-6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy, HUM GENE TH, 10(17), 1999, pp. 2769-2778
Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT
Authors: Qin, XS Liu, LL Gerson, SL
Citation: Xs. Qin et al., Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT, ONCOGENE, 18(30), 1999, pp. 4394-4400
Mice over-expressing human O(6)alkylguanine-DNA alkyltransferase selectively reduce O(6)methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea
Authors: Allay, E Veigl, M Gerson, SL
Citation: E. Allay et al., Mice over-expressing human O(6)alkylguanine-DNA alkyltransferase selectively reduce O(6)methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea, ONCOGENE, 18(25), 1999, pp. 3783-3787
Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis (2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer
Authors: Koc, ON Reese, JS Szekely, EM Gerson, SL
Citation: On. Koc et al., Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis (2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer, CANC GENE T, 6(4), 1999, pp. 340-348
Acquired resistance to O-6-benzylguanine plus chloroethylnitrosoureas in human breast cancer
Authors: Phillips, WP Gerson, SL
Citation: Wp. Phillips et Sl. Gerson, Acquired resistance to O-6-benzylguanine plus chloroethylnitrosoureas in human breast cancer, CANC CHEMOT, 44(4), 1999, pp. 319-326
Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases
Authors: Koc, ON Peters, C Aubourg, P Raghavan, S Dyhouse, S DeGasperi, R Kolodny, EH BenYoseph, Y Gerson, SL Lazarus, HM Caplan, AI Watkins, PA Krivit, W
Citation: On. Koc et al., Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases, EXP HEMATOL, 27(11), 1999, pp. 1675-1681
Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis
Authors: Qin, XS Zhou, H Liu, LL Gerson, SL
Citation: Xs. Qin et al., Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis, CARCINOGENE, 20(9), 1999, pp. 1667-1673
Reduced lung tumorigenesis in human methylguanine DNA-methyltransferase transgenic mice achieved by expression of transgene within the target cell
Authors: Liu, LL Qin, XS Gerson, SL
Citation: Ll. Liu et al., Reduced lung tumorigenesis in human methylguanine DNA-methyltransferase transgenic mice achieved by expression of transgene within the target cell, CARCINOGENE, 20(2), 1999, pp. 279-284
O-6-benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directrd DNA repair
Authors: Spiro, TP Gerson, SL Liu, LL Majka, S Haaga, J Hoppel, CL Ingalls, ST Pluda, JM Willson, JKV
Citation: Tp. Spiro et al., O-6-benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directrd DNA repair, CANCER RES, 59(10), 1999, pp. 2402-2410
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