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Results: 1-15 |
Results: 15
Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones
Authors: Nicolaou, KC Namoto, K Li, J Ritzen, A Ulven, T Shoji, M Zaharevitz, D Gussio, R Sackett, DL Ward, RD Hensler, A Fojo, T Giannakakou, P
Citation: Kc. Nicolaou et al., Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones, CHEMBIOCHEM, 2(1), 2001, pp. 69-75
Expression of beta-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-anticancer drug screen: Correlation with sensitivity to microtubule active agents
Authors: Nicoletti, MI Valoti, G Giannakakou, P Zhan, ZR Kim, JH Lucchini, V Landoni, F Mayo, JG Giavazzi, R Fojo, T
Citation: Mi. Nicoletti et al., Expression of beta-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-anticancer drug screen: Correlation with sensitivity to microtubule active agents, CLIN CANC R, 7(9), 2001, pp. 2912-2922
Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
Authors: Giannakakou, P Robey, R Fojo, T Blagosklonny, MV
Citation: P. Giannakakou et al., Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity, ONCOGENE, 20(29), 2001, pp. 3806-3813
Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions
Authors: Blagosklonny, MV Giannakakou, P Romanova, LY Ryan, KM Vousden, KH Fojo, T
Citation: Mv. Blagosklonny et al., Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions, CARCINOGENE, 22(6), 2001, pp. 861-867
Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism
Authors: Poruchynsky, MS Giannakakou, P Ward, Y Bulinski, JC Telford, WG Robey, RW Fojo, T
Citation: Ms. Poruchynsky et al., Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism, BIOCH PHARM, 62(11), 2001, pp. 1469-1480
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues
Authors: Nicolaou, KC Namoto, K Ritzen, A Ulven, T Shoji, M Li, J D'Amico, G Liotta, D French, CT Wartmann, M Altmann, KH Giannakakou, P
Citation: Kc. Nicolaou et al., Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues, J AM CHEM S, 123(38), 2001, pp. 9313-9323
Mutants yield a pharmacophore model for the tubulin-paclitaxel binding site - Reply
Authors: Gussio, R Fojo, T Giannakakou, P
Citation: R. Gussio et al., Mutants yield a pharmacophore model for the tubulin-paclitaxel binding site - Reply, TRENDS PHAR, 21(9), 2000, pp. 323-324
Tubulin/microtubules: Still a promising target for new chemotherapeutic agents
Authors: Giannakakou, P Sackett, D Fojo, T
Citation: P. Giannakakou et al., Tubulin/microtubules: Still a promising target for new chemotherapeutic agents, J NAT CANC, 92(3), 2000, pp. 182-183
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
Authors: Giannakakou, P Sackett, DL Ward, Y Webster, KR Blagosklonny, MV Fojo, T
Citation: P. Giannakakou et al., p53 is associated with cellular microtubules and is transported to the nucleus by dynein, NAT CELL BI, 2(10), 2000, pp. 709-717
Discodermolide: Just another microtubule-stabilizing agent? No! A lesson in synergy
Authors: Giannakakou, P Fojo, T
Citation: P. Giannakakou et T. Fojo, Discodermolide: Just another microtubule-stabilizing agent? No! A lesson in synergy, CLIN CANC R, 6(5), 2000, pp. 1613-1615
Chemical synthesis and biological properties of pyridine epothilones
Authors: Nicolaou, KC Scarpelli, R Bollbuck, B Werschkun, B Pereira, MMA Wartmann, M Altmann, KH Zaharevitz, D Gussio, R Giannakakou, P
Citation: Kc. Nicolaou et al., Chemical synthesis and biological properties of pyridine epothilones, CHEM BIOL, 7(8), 2000, pp. 593-599
Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer
Authors: Giannakakou, P Poy, G Zhan, ZR Knutsen, T Blagosklonny, MV Fojo, T
Citation: P. Giannakakou et al., Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer, ONCOGENE, 19(27), 2000, pp. 3078-3085
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
Authors: Giannakakou, P Gussio, R Nogales, E Downing, KH Zaharevitz, D Bollbuck, B Poy, G Sackett, D Nicolaou, KC Fojo, T
Citation: P. Giannakakou et al., A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells, P NAS US, 97(6), 2000, pp. 2904-2909
Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein
Authors: Gabriele, L Phung, J Fukumoto, J Segal, D Wang, IM Giannakakou, P Giese, N Ozata, K Morse, HC
Citation: L. Gabriele et al., Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein, J EXP MED, 190(3), 1999, pp. 411-421
Regulation of apoptosis in myeloid cells by interferon consensus sequence-binging proteins (vol 190, pg 411, 1999)
Authors: Gabriele, L Phung, J Fukomoto, J Segal, D Wang, IM Giannakakou, P Giese, N Ozata, K Morse, HC
Citation: L. Gabriele et al., Regulation of apoptosis in myeloid cells by interferon consensus sequence-binging proteins (vol 190, pg 411, 1999), J EXP MED, 190(11), 1999, pp. 1723-1723
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