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Results: 1-10 |
Results: 10
Lead generation and lead optimisation approaches in the discovery of selective, non-peptide ORL-1 receptor agonists and antagonists
Authors: Ronzoni, S Peretto, L Giardina, GAM
Citation: S. Ronzoni et al., Lead generation and lead optimisation approaches in the discovery of selective, non-peptide ORL-1 receptor agonists and antagonists, EXPERT OP T, 11(4), 2001, pp. 525-546
A new synthetic approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one (J-113397), the first non-peptide ORL-1 receptor antagonist
Authors: De Risi, C Pollini, GP Trapella, C Peretto, I Ronzoni, S Giardina, GAM
Citation: C. De Risi et al., A new synthetic approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one (J-113397), the first non-peptide ORL-1 receptor antagonist, BIO MED CH, 9(7), 2001, pp. 1871-1877
Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity andselectivity in quinoline tachykinin receptor antagonists
Authors: Blaney, FE Raveglia, LF Artico, M Cavagnera, S Dartois, C Farina, C Grugni, M Gagliardi, S Luttmann, MA Martinelli, M Nadler, GMMG Parini, C Petrillo, P Sarau, HM Scheideler, MA Hay, DWP Giardina, GAM
Citation: Fe. Blaney et al., Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity andselectivity in quinoline tachykinin receptor antagonists, J MED CHEM, 44(11), 2001, pp. 1675-1689
Molecular and pharmacological characterization of the murine tachykinin NK3 receptor
Authors: Sarau, HM Feild, JA Ames, RS Foley, JJ Nuthulaganti, P Schmidt, DB Buckley, PT Elshourbagy, NA Brawner, ME Luttmann, MA Giardina, GAM Hay, DWP
Citation: Hm. Sarau et al., Molecular and pharmacological characterization of the murine tachykinin NK3 receptor, EUR J PHARM, 413(2-3), 2001, pp. 143-150
The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics
Authors: Barlocco, D Cignarella, G Giardina, GAM Toma, L
Citation: D. Barlocco et al., The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics, EUR J MED C, 35(3), 2000, pp. 275-282
Evidence that the proposed novel human "neurokinin-4" receptor is pharmacologically similar to the human neurokinin-3 receptor but is not of human origin
Authors: Sarau, HM Mooney, JL Schmidt, DB Foley, JJ Buckley, PT Giardina, GAM Wang, DY Lee, JA Hay, DWP
Citation: Hm. Sarau et al., Evidence that the proposed novel human "neurokinin-4" receptor is pharmacologically similar to the human neurokinin-3 receptor but is not of human origin, MOLEC PHARM, 58(3), 2000, pp. 552-559
Nonpeptide tachykinin receptor antagonists. II. Ppharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potentand selective NK-3 receptor antagonist
Authors: Sarau, HM Griswold, DE Bush, B Potts, W Sandhu, P Lundberg, D Foley, JJ Schmidt, DB Webb, EF Martin, LD Legos, JJ Whitmore, RG Barone, FC Medhurst, AD Luttmann, MA Giardina, GAM Hay, DWP
Citation: Hm. Sarau et al., Nonpeptide tachykinin receptor antagonists. II. Ppharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potentand selective NK-3 receptor antagonist, J PHARM EXP, 295(1), 2000, pp. 373-381
Investigation of SAR requirements of SR 142801 through an indexed combinatorial library in solution
Authors: Raveglia, LF Vitali, M Artico, M Graziani, D Hay, DWP Luttmann, MA Mena, R Pifferi, G Giardina, GAM
Citation: Lf. Raveglia et al., Investigation of SAR requirements of SR 142801 through an indexed combinatorial library in solution, EUR J MED C, 34(10), 1999, pp. 825-835
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412)
Authors: Giardina, GAM Raveglia, LF Grugni, M Sarau, HM Farina, C Medhurst, AD Graziani, D Schmidt, DB Rigolio, R Luttmann, M Cavagnera, S Foley, JJ Vecchietti, V Hay, DWP
Citation: Gam. Giardina et al., Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412), J MED CHEM, 42(6), 1999, pp. 1053-1065
Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonists
Authors: Giardina, GAM Artico, M Cavagnera, S Cerri, A Consolandi, E Gagliardi, S Graziani, D Grugni, M Hay, DWP Luttmann, MA Mena, R Raveglia, LF Rigolio, R Sarau, HM Schmidt, DB Zanoni, G Farina, C
Citation: Gam. Giardina et al., Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonists, FARMACO, 54(6), 1999, pp. 364-374
Risultati: 1-10 |