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Results: 1-25 | 26-42
Results: 1-25/42
Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: A short-term model for evaluation of antiresorptive therapy
Authors: Stroup, GB Hoffman, SJ Vasko-Moser, JA Lechowska, BA Jenkins, EL Dare, LC Gowen, M
Citation: Gb. Stroup et al., Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: A short-term model for evaluation of antiresorptive therapy, BONE, 28(5), 2001, pp. 532-537
Biosynthesis and processing of cathepsin K in cultured human osteoclasts
Authors: Rieman, DJ McClung, HA Dodds, RA Hwang, SM Lark, MW Holmes, S James, IE Drake, FH Gowen, M
Citation: Dj. Rieman et al., Biosynthesis and processing of cathepsin K in cultured human osteoclasts, BONE, 28(3), 2001, pp. 282-289
Clusterin expression in adult human normal and osteoarthritic articular cartilage
Authors: Connor, JR Kumar, S Sathe, G Mooney, J O'Brien, SP Mui, P Murdock, PR Gowen, M Lark, MW
Citation: Jr. Connor et al., Clusterin expression in adult human normal and osteoarthritic articular cartilage, OSTEO CART, 9(8), 2001, pp. 727-737
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries
Authors: Kumar, S Connor, JR Dodds, RA Halsey, W Van Horn, M Mao, J Sathe, G Mui, P Agarwal, P Badger, AM Lee, JC Gowen, M Lark, MW
Citation: S. Kumar et al., Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries, OSTEO CART, 9(7), 2001, pp. 641-653
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption
Authors: Dodds, RA James, IE Rieman, D Ahern, R Hwang, SM Connor, JR Thompson, SD Veber, DF Drake, FH Holmes, S Lark, MW Gowen, M
Citation: Ra. Dodds et al., Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption, J BONE MIN, 16(3), 2001, pp. 478-486
Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat
Authors: Lark, MW Stroup, GB Dodds, RA Kapadia, R Hoffman, SJ Hwang, SM James, IE Lechowska, B Liang, XG Rieman, DJ Salyers, KL Ward, K Smith, BR Miller, WH Huffman, WF Gowen, M
Citation: Mw. Lark et al., Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat, J BONE MIN, 16(2), 2001, pp. 319-327
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate
Authors: Stroup, GB Lark, MW Veber, DF Bhattacharyya, A Blake, S Dare, LC Erhard, KF Hoffman, SJ James, IE Marquis, RW Ru, Y Vasko-Moser, JA Smith, BR Tomaszek, T Gowen, M
Citation: Gb. Stroup et al., Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate, J BONE MIN, 16(10), 2001, pp. 1739-1746
Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents
Authors: Nuttall, ME Pendrak, I Emery, JG Nadeau, DP Fisher, PW Nicholson, TA Zhu, Y Suva, LJ Kingsbury, WD Gowen, M
Citation: Me. Nuttall et al., Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents, CANC CHEMOT, 47(5), 2001, pp. 437-443
Calcilytic compounds: Potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone
Authors: Nemeth, EF Delmar, EG Heaton, WL Miller, MA Lambert, LD Conklin, RL Gowen, M Gleason, JG Bhatnagar, PK Fox, J
Citation: Ef. Nemeth et al., Calcilytic compounds: Potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone, J PHARM EXP, 299(1), 2001, pp. 323-331
Azepanone-based inhibitors of human and rat cathepsin K
Authors: Marquis, RW Ru, Y LoCastro, SM Zeng, J Yamashita, DS Oh, HJ Erhard, KF Davis, LD Tomaszek, TA Tew, D Salyers, K Proksch, J Ward, K Smith, B Levy, M Cummings, MD Haltiwanger, RC Trescher, G Wang, B Hemling, ME Quinn, CJ Cheng, HY Lin, F Smith, WW Janson, CA Zhao, BG McQueney, MS D'Alessio, K Lee, CP Marzulli, A Dodds, RA Blake, S Hwang, SM James, IE Gress, CJ Bradley, BR Lark, MW Gowen, M Veber, DF
Citation: Rw. Marquis et al., Azepanone-based inhibitors of human and rat cathepsin K, J MED CHEM, 44(9), 2001, pp. 1380-1395
IL-1-and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase
Authors: Kumar, S Votta, BJ Rieman, DJ Badger, AM Gowen, M Lee, JC
Citation: S. Kumar et al., IL-1-and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase, J CELL PHYS, 187(3), 2001, pp. 294-303
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro
Authors: James, IE Marquis, RW Blake, SM Hwang, SM Gress, CJ Ru, Y Zembryki, D Yamashita, DS McQueney, MS Tomaszek, TA Oh, HJ Gowen, M Veber, DF Lark, MW
Citation: Ie. James et al., Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro, J BIOL CHEM, 276(15), 2001, pp. 11507-11511
Disease-modifying activity of SB 273005, an orally active, nonpeptide alpha(v)beta(3) (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis
Authors: Badger, AM Blake, S Kapadia, R Sarkar, S Levin, J Swift, BA Hoffman, SJ Stroup, GB Miller, WH Gowen, M Lark, MW
Citation: Am. Badger et al., Disease-modifying activity of SB 273005, an orally active, nonpeptide alpha(v)beta(3) (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis, ARTH RHEUM, 44(1), 2001, pp. 128-137
Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: Loss of antigenicity by treatment with cathepsin K
Authors: Sassi, ML Eriksen, H Risteli, L Niemi, S Mansell, J Gowen, M Risteli, J
Citation: Ml. Sassi et al., Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: Loss of antigenicity by treatment with cathepsin K, BONE, 26(4), 2000, pp. 367-373
Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocytecultures
Authors: Badger, AM Roshak, AK Cook, MN Newman-Tarr, TM Swift, BA Carlson, K Connor, JR Lee, JC Gowen, M Lark, MW Kumar, S
Citation: Am. Badger et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocytecultures, OSTEO CART, 8(6), 2000, pp. 434-443
FrzB-2: a human secreted frizzled-related protein with a potential role inchondrocyte apoptosis
Authors: James, IE Kumar, S Barnes, MR Gress, CJ Hand, AT Dodds, RA Connor, JR Bradley, BR Campbell, DA Grabill, SE Williams, K Blake, SM Gowen, M Lark, MW
Citation: Ie. James et al., FrzB-2: a human secreted frizzled-related protein with a potential role inchondrocyte apoptosis, OSTEO CART, 8(6), 2000, pp. 452-463
Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage
Authors: Wang, FL Connor, JR Dodds, RA James, IE Kumar, S Zou, C Lark, MW Gowen, M Nuttall, ME
Citation: Fl. Wang et al., Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage, OSTEO CART, 8(3), 2000, pp. 161-169
Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization
Authors: Connor, JR Dodds, RA Emery, JG Kirkpatrick, RB Rosenberg, M Gowen, M
Citation: Jr. Connor et al., Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization, OSTEO CART, 8(2), 2000, pp. 87-95
The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro
Authors: Nuttall, ME Fisher, PW Suva, LJ Gowen, M
Citation: Me. Nuttall et al., The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro, EUR J CANC, 36, 2000, pp. S63-S64
Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro
Authors: Nuttall, ME Nadeau, DP Fisher, PW Wang, F Keller, PM DeWolf, WE Goldring, MB Badger, AM Lee, D Levy, MA Gowen, M Lark, MW
Citation: Me. Nuttall et al., Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro, J ORTHOP R, 18(3), 2000, pp. 356-363
Identification and cloning of a human urea transporter HUT11, which is downregulated during adipogenesis of explant cultures of human bone
Authors: Prichett, WP Patton, AJ Field, JA Brun, KA Emery, JG Tan, KB Rieman, DJ McClung, HA Nadeau, DP Mooney, JL Suva, LJ Gowen, M Nuttall, ME
Citation: Wp. Prichett et al., Identification and cloning of a human urea transporter HUT11, which is downregulated during adipogenesis of explant cultures of human bone, J CELL BIOC, 76(4), 2000, pp. 639-650
Distinct mechanisms of action of selective estrogen receptor modulators inbreast and osteoblastic cells
Authors: Nuttall, ME Stroup, GB Fisher, PW Nadeau, DP Gowen, M Suva, LJ
Citation: Me. Nuttall et al., Distinct mechanisms of action of selective estrogen receptor modulators inbreast and osteoblastic cells, AM J P-CELL, 279(5), 2000, pp. C1550-C1557
Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic
Authors: Miller, WH Alberts, DP Bhatnagar, PK Bondinell, WE Callahan, JF Calvo, RR Cousins, RD Erhard, KF Heerding, DA Keenan, RM Kwon, C Manley, PJ Newlander, KA Ross, ST Samanen, JM Uzinskas, IN Venslavsky, JW Yuan, CCK Haltiwanger, RC Gowen, M Hwang, SM James, IE Lark, MW Rieman, DJ Stroup, GB Azzarano, LM Salyers, KL Smith, BR Ward, KW Johanson, KO Huffman, WF
Citation: Wh. Miller et al., Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic, J MED CHEM, 43(1), 2000, pp. 22-26
A selective inhibitor of the osteoclastic V-H+-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats
Authors: Visentin, L Dodds, RA Valente, M Misiano, P Bradbeer, JN Oneta, S Liang, XG Gowen, M Farina, C
Citation: L. Visentin et al., A selective inhibitor of the osteoclastic V-H+-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats, J CLIN INV, 106(2), 2000, pp. 309-318
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
Authors: Gowen, M Stroup, GB Dodds, RA James, IE Votta, BJ Smith, BR Bhatnagar, PK Lago, AM Callahan, JF DelMar, EG Miller, MA Nemeth, EF Fox, J
Citation: M. Gowen et al., Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats, J CLIN INV, 105(11), 2000, pp. 1595-1604
Risultati: 1-25 | 26-42