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Results: 1-25 |
Results: 25
SYNTHESIS AND TYROSINE KINASE INHIBITORY ACTIVITY OF A SERIES OF 2-AMINO-8H-PYRIDO[2,3-D]PYRIMIDINES - IDENTIFICATION OF POTENT, SELECTIVE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITORS
Authors: BOSCHELLI DH WU ZP KLUTCHKO SR SHOWALTER HDH HAMBY JM LU GH MAJOR TC DAHRING TK BATLEY B PANEK RL KEISER J HARTL BG KRAKER AJ KLOHS WD ROBERTS BJ PATMORE S ELLIOTT WL STEINKAMPF R BRADFORD LA HALLAK H DOHERTY AM
Citation: Dh. Boschelli et al., SYNTHESIS AND TYROSINE KINASE INHIBITORY ACTIVITY OF A SERIES OF 2-AMINO-8H-PYRIDO[2,3-D]PYRIMIDINES - IDENTIFICATION OF POTENT, SELECTIVE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITORS, Journal of medicinal chemistry, 41(22), 1998, pp. 4365-4377
2-SUBSTITUTED AMINOPYRIDO[2,3-D]PYRIMIDIN-7(8H) ONES - STRUCTURE-ACTIVITY-RELATIONSHIPS AGAINST SELECTED TYROSINE KINASES AND IN-VITRO AND IN-VIVO ANTICANCER ACTIVITY
Authors: KLUTCHKO SR HAMBY JM BOSCHELLI DH WU ZP KRAKER AJ AMAR AM HARTL BG SHEN C KLOHS WD STEINKAMPF RW DRISCOLL DL NELSON JM ELLIOTT WL ROBERTS BJ STONER CL VINCENT PW DYKES DJ PANEK RL LU GH MAJOR TC DAHRING TK HALLAK H BRADFORD LA SHOWALTER HDH DOHERTY AM
Citation: Sr. Klutchko et al., 2-SUBSTITUTED AMINOPYRIDO[2,3-D]PYRIMIDIN-7(8H) ONES - STRUCTURE-ACTIVITY-RELATIONSHIPS AGAINST SELECTED TYROSINE KINASES AND IN-VITRO AND IN-VIVO ANTICANCER ACTIVITY, Journal of medicinal chemistry, 41(17), 1998, pp. 3276-3292
MATRIX METALLOPROTEINASE INHIBITOR, PD-166793, ALTERS PROGRESSION OF HEART-FAILURE IN THE MYOCARDIAL INFARCTED
Authors: PETERSON T SANCHEZ B ROBERTSON A ROSEBURY W BRYANT JW DILLON L HALLAK H JOHNSON L BOCAN TMA
Citation: T. Peterson et al., MATRIX METALLOPROTEINASE INHIBITOR, PD-166793, ALTERS PROGRESSION OF HEART-FAILURE IN THE MYOCARDIAL INFARCTED, Circulation, 98(17), 1998, pp. 2200-2200
GAMMA-CARBAMATE BUTENOLIDE ANALOGS AS POTENT ET(A) SELECTIVE ENDOTHELIN RECEPTOR ANTAGONISTS AND PRODRUGS
Authors: PATT WC REISDORPH BR REPINE JT DOHERTY AM HALEEN SJ WALKER DM WELCH KM FLYNN MA HALLAK H REYNER EL STEWART BH
Citation: Wc. Patt et al., GAMMA-CARBAMATE BUTENOLIDE ANALOGS AS POTENT ET(A) SELECTIVE ENDOTHELIN RECEPTOR ANTAGONISTS AND PRODRUGS, Bioorganic & medicinal chemistry letters, 7(3), 1997, pp. 297-302
PHARMACODYNAMICS OF PD-156707, A SELECTIVE ENDOTHELIN RECEPTOR-A (ET(A)) ANTAGONIST, IN ACUTE HYPOXIC PULMONARY-HYPERTENSION (PH)
Authors: KEISER JA SCHROEDER RL HALLAK H UPRICHARD ACG DOHERTY AM HALEEN SJ
Citation: Ja. Keiser et al., PHARMACODYNAMICS OF PD-156707, A SELECTIVE ENDOTHELIN RECEPTOR-A (ET(A)) ANTAGONIST, IN ACUTE HYPOXIC PULMONARY-HYPERTENSION (PH), The FASEB journal, 11(3), 1997, pp. 206-206
IN-VITRO PHARMACOLOGICAL CHARACTERIZATION OF PD-166285, A NEW NANOMOLAR POTENT AND BROADLY ACTIVE PROTEIN-TYROSINE KINASE INHIBITOR
Authors: PANEK RL LU GH KLUTCHKO SR BATLEY BL DAHRING TK HAMBY JM HALLAK H DOHERTY AM KEISER JA
Citation: Rl. Panek et al., IN-VITRO PHARMACOLOGICAL CHARACTERIZATION OF PD-166285, A NEW NANOMOLAR POTENT AND BROADLY ACTIVE PROTEIN-TYROSINE KINASE INHIBITOR, The Journal of pharmacology and experimental therapeutics, 283(3), 1997, pp. 1433-1444
STRUCTURE-ACTIVITY-RELATIONSHIPS IN A SERIES OF ORALLY-ACTIVE GAMMA-HYDROXY BUTENOLIDE ENDOTHELIN ANTAGONISTS
Authors: PATT WC EDMUNDS JJ REPINE JT BERRYMAN KA REISDORPH BR LEE C PLUMMER MS SHAHRIPOUR A HALEEN SJ KEISER JA FLYNN MA WELCH KM REYNOLDS EE RUBIN R TOBIAS B HALLAK H DOHERTY AM
Citation: Wc. Patt et al., STRUCTURE-ACTIVITY-RELATIONSHIPS IN A SERIES OF ORALLY-ACTIVE GAMMA-HYDROXY BUTENOLIDE ENDOTHELIN ANTAGONISTS, Journal of medicinal chemistry, 40(7), 1997, pp. 1063-1074
STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS
Authors: HAMBY JM CONNOLLY CJC SCHROEDER MC WINTERS RT SHOWALTER HDH PANEK RL MAJOR TC OLSEWSKI B RYAN MJ DAHRING T LU GH KEISER J AMAR A SHEN C KRAKER AJ SLINTAK V NELSON JM FRY DW BRADFORD L HALLAK H DOHERTY AM
Citation: Jm. Hamby et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS, Journal of medicinal chemistry, 40(15), 1997, pp. 2296-2303
EFFECTS OF ENDOTHELIN ET(A)-RECEPTOR ANTAGONISM WITH PD-156707 ON HEMODYNAMICS AND RENAL VASCULAR-RESISTANCE IN RABBITS
Authors: IGNASIAK DP MCCLANAHAN TB SAGANEK LJ POTOCZAK RE HALLAK H GALLAGHER KP
Citation: Dp. Ignasiak et al., EFFECTS OF ENDOTHELIN ET(A)-RECEPTOR ANTAGONISM WITH PD-156707 ON HEMODYNAMICS AND RENAL VASCULAR-RESISTANCE IN RABBITS, European journal of pharmacology, 321(3), 1997, pp. 295-300
SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS OF CL-1000, A NEW PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR, IN HEALTHY-VOLUNTEERS
Authors: HOUNSLOW N SHAILER P HALLAK H BRON N MANT T SIMMONDS H SEDMAN A VASSOS A
Citation: N. Hounslow et al., SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS OF CL-1000, A NEW PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR, IN HEALTHY-VOLUNTEERS, Clinical pharmacology and therapeutics, 61(2), 1997, pp. 98-98
MATRIX METALLOPROTEINASE INHIBITION BLOCKS PROGRESSION OF HEART-FAILURE
Authors: PETERSON JT ROSEBURY WS ROBERTSON AW WASHINGTON RA LI H OBRIEN PM SLISKOVIC DR HALLAK H UPRICHARD ACG BOCAN TMA
Citation: Jt. Peterson et al., MATRIX METALLOPROTEINASE INHIBITION BLOCKS PROGRESSION OF HEART-FAILURE, Circulation, 96(8), 1997, pp. 2916-2916
LIQUID-CHROMATOGRAPHIC ASSAY FOR A BENENOLIDE ENDOTHELIN ANTAGONIST (PD-156707) IN PLASMA
Authors: ROSSI DT HALLAK H BRADFORD L
Citation: Dt. Rossi et al., LIQUID-CHROMATOGRAPHIC ASSAY FOR A BENENOLIDE ENDOTHELIN ANTAGONIST (PD-156707) IN PLASMA, Journal of chromatography B. Biomedical applications, 677(2), 1996, pp. 299-304
THE STAIRCASE SOLAR DRYER - DESIGN AND CHARACTERISTICS
Authors: HALLAK H HILAL J HILAL F RAHHAL R
Citation: H. Hallak et al., THE STAIRCASE SOLAR DRYER - DESIGN AND CHARACTERISTICS, Renewable energy, 7(2), 1996, pp. 177-183
ENDOTHELIN RECEPTOR ANTAGONIST INCREASES CEREBRAL PERFUSION AND REDUCES ISCHEMIC DAMAGE IN FELINE FOCAL CEREBRAL-ISCHEMIA
Authors: PATEL TR GALBRAITH S GRAHAM DI HALLAK H DOHERTY AM MCCULLOCH J
Citation: Tr. Patel et al., ENDOTHELIN RECEPTOR ANTAGONIST INCREASES CEREBRAL PERFUSION AND REDUCES ISCHEMIC DAMAGE IN FELINE FOCAL CEREBRAL-ISCHEMIA, Journal of cerebral blood flow and metabolism, 16(5), 1996, pp. 950-958
ENDOTHELIN(A) RECEPTOR ANTAGONISM BY PD-156707 DOES NOT REDUCE INFARCT SIZE AFTER CORONARY-ARTERY OCCLUSION REPERFUSION IN PIGS/
Authors: MERTZ TE MCCLANAHAN TB FLYNN MA JUNEAU P REYNOLDS EE HALLAK H BRADFORD L GALLAGHER KP
Citation: Te. Mertz et al., ENDOTHELIN(A) RECEPTOR ANTAGONISM BY PD-156707 DOES NOT REDUCE INFARCT SIZE AFTER CORONARY-ARTERY OCCLUSION REPERFUSION IN PIGS/, The Journal of pharmacology and experimental therapeutics, 278(1), 1996, pp. 42-49
PREVENTION OF SUBARACHNOID HEMORRHAGE-INDUCED CEREBRAL VASOSPASM BY ORAL-ADMINISTRATION OF ENDOTHELIN RECEPTOR ANTAGONISTS
Authors: ZUCCARELLO M SOATTIN GB LEWIS AI BREU V HALLAK H RAPOPORT RM
Citation: M. Zuccarello et al., PREVENTION OF SUBARACHNOID HEMORRHAGE-INDUCED CEREBRAL VASOSPASM BY ORAL-ADMINISTRATION OF ENDOTHELIN RECEPTOR ANTAGONISTS, Journal of neurosurgery, 84(3), 1996, pp. 503-507
EXPRESSION OF THE HUMAN 5-HT1A RECEPTOR IN SF9 CELLS - RECONSTITUTIONOF A COUPLED PHENOTYPE BY COEXPRESSION OF MAMMALIAN G-PROTEIN SUBUNITS
Authors: BUTKERAIT P MILLER HA BURRIS KD ZHENG YJ HALLAK H GRAHAM TE MOLINOFF PB MANNING DR
Citation: P. Butkerait et al., EXPRESSION OF THE HUMAN 5-HT1A RECEPTOR IN SF9 CELLS - RECONSTITUTIONOF A COUPLED PHENOTYPE BY COEXPRESSION OF MAMMALIAN G-PROTEIN SUBUNITS, The FASEB journal, 9(6), 1995, pp. 1412-1412
SUBACUTE TOXICITY OF A PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR IN RATS
Authors: WOLFGANG GHI BLEAVINS MR HALLAK H KASALI OB URDA E
Citation: Ghi. Wolfgang et al., SUBACUTE TOXICITY OF A PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR IN RATS, Fundamental and applied toxicology, 28(1), 1995, pp. 51-58
STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL SERIES OF ORALLY-ACTIVE NONPEPTIDE ET(A) AND ET(A B) ENDOTHELIN RECEPTOR-SELECTIVE ANTAGONISTS/
Authors: DOHERTY AM PATT WC REPINE J EDMUNDS JJ BERRYMAN KA REISDORPH BR WALKER DM HALEEN SJ KEISER JA FLYNN MA WELCH KM HALLAK H REYNOLDS EE
Citation: Am. Doherty et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL SERIES OF ORALLY-ACTIVE NONPEPTIDE ET(A) AND ET(A B) ENDOTHELIN RECEPTOR-SELECTIVE ANTAGONISTS/, Journal of cardiovascular pharmacology, 26, 1995, pp. 358-361
DISCOVERY OF A NOVEL SERIES OF ORALLY-ACTIVE NONPEPTIDE ENDOTHELIN-A (ET(A)) RECEPTOR-SELECTIVE ANTAGONISTS
Authors: DOHERTY AM PATT WC EDMUNDS JJ BERRYMAN KA REISDORPH BR PLUMMER MS SHAHRIPOUR A LEE C CHENG XM WALKER DM HALEEN SJ KEISER JA FLYNN MA WELCH KM HALLAK H TAYLOR DG REYNOLDS EE
Citation: Am. Doherty et al., DISCOVERY OF A NOVEL SERIES OF ORALLY-ACTIVE NONPEPTIDE ENDOTHELIN-A (ET(A)) RECEPTOR-SELECTIVE ANTAGONISTS, Journal of medicinal chemistry, 38(8), 1995, pp. 1259-1263
EXPRESSION OF THE HUMAN 5-HYDROXYTRYPTAMINE(1A) RECEPTOR IN SF9 CELLS- RECONSTITUTION OF A COUPLED PHENOTYPE BY COEXPRESSION OF MAMMALIAN G-PROTEIN SUBUNITS
Authors: BUTKERAIT P ZHENG YJ HALLAK H GRAHAM TE MILLER HA BURRIS KD MOLINOFF PB MANNINGS DR
Citation: P. Butkerait et al., EXPRESSION OF THE HUMAN 5-HYDROXYTRYPTAMINE(1A) RECEPTOR IN SF9 CELLS- RECONSTITUTION OF A COUPLED PHENOTYPE BY COEXPRESSION OF MAMMALIAN G-PROTEIN SUBUNITS, The Journal of biological chemistry, 270(31), 1995, pp. 18691-18699
ENDOTHELIN(A) RECEPTOR ANTAGONISM BY PD156707 DOES NOT REDUCE INFARCTSIZE FOLLOWING CORONARY-ARTERY OCCLUSION-REPERFUSION IN PIGS
Authors: MERTZ TE MCCLANAHAN TB FLYNN MA REYNOLDS EE BRADFORD L HALLAK H GALLAGHER KP
Citation: Te. Mertz et al., ENDOTHELIN(A) RECEPTOR ANTAGONISM BY PD156707 DOES NOT REDUCE INFARCTSIZE FOLLOWING CORONARY-ARTERY OCCLUSION-REPERFUSION IN PIGS, Circulation, 92(8), 1995, pp. 2173-2173
COVALENT BINDING OF ARACHIDONATE TO G-PROTEIN ALPHA-SUBUNITS OF HUMANPLATELETS
Authors: HALLAK H MUSZBEK L LAPOSATA M BELMONTE E BRASS LF MANNING DR
Citation: H. Hallak et al., COVALENT BINDING OF ARACHIDONATE TO G-PROTEIN ALPHA-SUBUNITS OF HUMANPLATELETS, The Journal of biological chemistry, 269(7), 1994, pp. 4713-4716
FAILURE TO MYRISTOYLATE THE ALPHA-SUBUNIT OF G(Z) IS CORRELATED WITH AN INHIBITION OF PALMITOYLATION AND MEMBRANE ATTACHMENT, BUT HAS NO AFFECT ON PHOSPHORYLATION BY PROTEIN-KINASE-C
Authors: HALLAK H BRASS LF MANNING DR
Citation: H. Hallak et al., FAILURE TO MYRISTOYLATE THE ALPHA-SUBUNIT OF G(Z) IS CORRELATED WITH AN INHIBITION OF PALMITOYLATION AND MEMBRANE ATTACHMENT, BUT HAS NO AFFECT ON PHOSPHORYLATION BY PROTEIN-KINASE-C, The Journal of biological chemistry, 269(6), 1994, pp. 4571-4576
N-MYRISTOYLATION IS REQUIRED FOR ANCHORAGE BUT NOT PHOSPHORYLATION OFTHE ALPHA-SUBUNIT OF GZ
Authors: HALLAK H MANNING DR
Citation: H. Hallak et Dr. Manning, N-MYRISTOYLATION IS REQUIRED FOR ANCHORAGE BUT NOT PHOSPHORYLATION OFTHE ALPHA-SUBUNIT OF GZ, The FASEB journal, 7(7), 1993, pp. 1045-1045
Risultati: 1-25 |