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Results: 1-15 |
Results: 15
TIPRANAVIR (PNU-140690) - A POTENT, ORALLY BIOAVAILABLE NONPEPTIDIC HIV PROTEASE INHIBITOR OF THE 5,6-DIHYDRO-4-HYDROXY-2-PYRONE SULFONAMIDE CLASS
Authors: TURNER SR STROHBACH JW TOMMASI RA ARISTOFF PA JOHNSON PD SKULNICK HI DOLAK LA SEEST EP TOMICH PK BOHANAN MJ HORNG MM LYNN JC CHONG KT HINSHAW RR WATENPAUGH KD JANAKIRAMAN MN THAISRIVONGS S
Citation: Sr. Turner et al., TIPRANAVIR (PNU-140690) - A POTENT, ORALLY BIOAVAILABLE NONPEPTIDIC HIV PROTEASE INHIBITOR OF THE 5,6-DIHYDRO-4-HYDROXY-2-PYRONE SULFONAMIDE CLASS, Journal of medicinal chemistry, 41(18), 1998, pp. 3467-3476
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SULFONE SUBSTITUTED HIV PROTEASE INHIBITORS
Authors: SCHWARTZ TM BUNDY GL STROHBACH JW THAISRIVONGS S JOHNSON PD SKULNICK HI TOMICH PK LYNN JC CHONG KT HINSHAW RR RAUB TJ PADBURY GE TOTH LN
Citation: Tm. Schwartz et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SULFONE SUBSTITUTED HIV PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 399-402
ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR
Authors: POPPE SM SLADE DE CHONG KT HINSHAW RR PAGANO PJ MARKOWITZ M HO DD MO H GORMAN RR DUEWEKE TJ THAISRIVONGS S TARPLEY WG
Citation: Sm. Poppe et al., ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR, Antimicrobial agents and chemotherapy, 41(5), 1997, pp. 1058-1063
STRUCTURE-BASED DESIGN OF NONPEPTIDIC HIV PROTEASE INHIBITORS - THE SULFONAMIDE-SUBSTITUTED CYCLOOCTYLPYRANONES
Authors: SKULNICK HI JOHNSON PD ARISTOFF PA MORRIS JK LOVASZ KD HOWE WJ WATENPAUGH KD JANAKIRAMAN MN ANDERSON DJ REISCHER RJ SCHWARTZ TM BANITT LS TOMICH PK LYNN JC HORNG MM CHONG KT HINSHAW RR DOLAK LA SEEST EP SCHWENDE FJ RUSH BD HOWARD GM TOTH LN WILKINSON KR KAKUK TJ JOHNSON CW COLE SL ZAYA RM ZIPP GL POSSERT PL DALGA RJ ZHONG WZ WILLIAMS MG ROMINES KR
Citation: Hi. Skulnick et al., STRUCTURE-BASED DESIGN OF NONPEPTIDIC HIV PROTEASE INHIBITORS - THE SULFONAMIDE-SUBSTITUTED CYCLOOCTYLPYRANONES, Journal of medicinal chemistry, 40(7), 1997, pp. 1149-1164
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS EFFECTIVE, NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S ROMERO DL TOMMASI RA JANAKIRAMAN MN STROHBACH JW TURNER SR BILES C MORGE RR JOHNSON PD ARISTOFF PA TOMICH PK LYNN JC HORNG MM CHONG KT HINSHAW RR HOWE WJ FINZEL BC WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS EFFECTIVE, NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(23), 1996, pp. 4630-4642
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S SKULNICK HI TURNER SR STROHBACH JW TOMMASI RA JOHNSON PD ARISTOFF PA JUDGE TM GAMMILL RB MORRIS JK ROMINES KR CHRUSCIEL RA HINSHAW RR CHONG KT TARPLEY WG POPPE SM SLADE DE LYNN JC HORNG MM TOMICH PK SEEST EP DOLAK LA HOWE WJ HOWARD GM SCHWENDE FJ TOTH LN PADBURY GE WILSON GJ SHIOU LH ZIPP GL WILKINSON KF RUSH BD RUWART MJ KOEPLINGER KA ZHAO ZY COLE S ZAYA RM KAKUK TJ JANAKIRAMAN MN WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(22), 1996, pp. 4349-4353
CYCLOALKYLPYRANONES AND CYCLOALKYLDIHYDROPYRONES AS HIV PROTEASE INHIBITORS - EXPLORING THE IMPACT OF RING SIZE ON STRUCTURE-ACTIVITY-RELATIONSHIPS
Authors: ROMINES KR MORRIS JK HOWE WJ TOMICH PK HORNG MM CHONG KT HINSHAW RR ANDERSON DJ STROHBACH JW TURNER SR MIZSAK SA
Citation: Kr. Romines et al., CYCLOALKYLPYRANONES AND CYCLOALKYLDIHYDROPYRONES AS HIV PROTEASE INHIBITORS - EXPLORING THE IMPACT OF RING SIZE ON STRUCTURE-ACTIVITY-RELATIONSHIPS, Journal of medicinal chemistry, 39(20), 1996, pp. 4125-4130
SYNTHESIS AND ANTIVIRAL ACTIVITY OF -2-PYRIDYL]-1-PIPERAZINYL]CARBONYL]-1H-INDOL-5-YL] (BHAP) ACYLSPHINGOSINE HIV REVERSE-TRANSCRIPTASE INHIBITORS
Authors: ISLAM I HINSHAW RR CHONG KT KATO A BORCHARDT RT FISHER JF
Citation: I. Islam et al., SYNTHESIS AND ANTIVIRAL ACTIVITY OF -2-PYRIDYL]-1-PIPERAZINYL]CARBONYL]-1H-INDOL-5-YL] (BHAP) ACYLSPHINGOSINE HIV REVERSE-TRANSCRIPTASE INHIBITORS, Bioorganic chemistry, 23(4), 1995, pp. 499-511
STRUCTURE-BASED DESIGN OF SULFONAMIDE-SUBSTITUTED NONPEPTIDIC HIV PROTEASE INHIBITORS
Authors: SKULNICK HI JOHNSON PD HOWE WJ TOMICH PK CHONG KT WATENPAUGH KD JANAKIRAMAN MN DOLAK LA MCGRATH JP LYNN JC HORNG MM HINSHAW RR ZIPP GL RUWART MJ SCHWENDE FJ ZHONG WZ PADBURY GE DALGA RJ SHIOU LH POSSERT PL RUSH BD WILKINSON KF HOWARD GM TOTH LN WILLIAMS MG KAKUK TJ COLE SL ZAYA RM LOVASZ KD MORRIS JK ROMINES KR THAISRIVONGS S ARISTOFF PA
Citation: Hi. Skulnick et al., STRUCTURE-BASED DESIGN OF SULFONAMIDE-SUBSTITUTED NONPEPTIDIC HIV PROTEASE INHIBITORS, Journal of medicinal chemistry, 38(26), 1995, pp. 4968-4971
STRUCTURE-BASED DESIGN OF NONPEPTIDIC HIV PROTEASE INHIBITORS FROM A CYCLOOCTYLPYRANONE LEAD STRUCTURE
Authors: ROMINES KR WATENPAUGH KD HOWE WJ TOMICH PK LOVASZ KD MORRIS JK JANAKIRAMAN MN LYNN JC HORNG MM CHONG KT HINSHAW RR DOLAK LA
Citation: Kr. Romines et al., STRUCTURE-BASED DESIGN OF NONPEPTIDIC HIV PROTEASE INHIBITORS FROM A CYCLOOCTYLPYRANONE LEAD STRUCTURE, Journal of medicinal chemistry, 38(22), 1995, pp. 4463-4473
STRUCTURE-BASED DESIGN OF NOVEL HIV PROTEASE INHIBITORS - CARBOXAMIDE-CONTAINING 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS POTENT NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S WATENPAUGH KD HOWE WJ TOMICH PK DOLAK LA CHONG KT TOMICH CSC TOMASSELLI AG TURNER SR STROHBACH JW MULICHAK AM JANAKIRAMAN MN MOON JB LYNN JC HORNG MM HINSHAW RR CURRY KA ROTHROCK DJ
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF NOVEL HIV PROTEASE INHIBITORS - CARBOXAMIDE-CONTAINING 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS POTENT NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 38(18), 1995, pp. 3624-3637
USE OF MEDIUM-SIZED CYCLOALKYL RINGS TO ENHANCE SECONDARY BINDING - DISCOVERY OF A NEW CLASS OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PROTEASEINHIBITORS
Authors: ROMINES KR WATENPAUGH KD TOMICH PK HOWE WJ MORRIS JK LOVASZ KD MULICHAK AM FINZEL BC LYNN JC HORNG MM SCHWENDE FJ RUWART MJ ZIPP GL CHONG KT DOLAK LA TOTH LN HOWARD GM RUSH BD WILKINSON KF POSSERT PL DALGA RJ HINSHAW RR
Citation: Kr. Romines et al., USE OF MEDIUM-SIZED CYCLOALKYL RINGS TO ENHANCE SECONDARY BINDING - DISCOVERY OF A NEW CLASS OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PROTEASEINHIBITORS, Journal of medicinal chemistry, 38(11), 1995, pp. 1884-1891
BISHETEROARYLPIPERAZINE REVERSE-TRANSCRIPTASE INHIBITOR IN COMBINATION WITH 3'-AZIDO-3'-DEOXYTHYMIDINE OR 2',3'-DIDEOXYCYTIDINE SYNERGISTICALLY INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION IN-VITRO
Authors: CHONG KT PAGANO PJ HINSHAW RR
Citation: Kt. Chong et al., BISHETEROARYLPIPERAZINE REVERSE-TRANSCRIPTASE INHIBITOR IN COMBINATION WITH 3'-AZIDO-3'-DEOXYTHYMIDINE OR 2',3'-DIDEOXYCYTIDINE SYNERGISTICALLY INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION IN-VITRO, Antimicrobial agents and chemotherapy, 38(2), 1994, pp. 288-293
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S TOMICH PK WATENPAUGH KD CHONG KT HOWE WJ YANG CP STROHBACH JW TURNER SR MCGRATH JP BOHANON MJ LYNN JC MULICHAK AM SPINELLI PA HINSHAW RR PAGANO PJ MOON JB RUWART MJ WILKINSON KF RUSH BD ZIPP GL DALGA RJ SCHWENDE FJ HOWARD GM PADBURY GE TOTH LN ZHAO ZY KOEPLINGER KA KAKUK TJ COLE SL ZAYA RM PIPER RC JEFFREY P
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 37(20), 1994, pp. 3200-3204
PEPTIDOMIMETIC HIV PROTEASE INHIBITORS - PHOSPHATE PRODRUGS WITH IMPROVED BIOLOGICAL-ACTIVITIES
Authors: CHONG KT RUWART MJ HINSHAW RR WILKINSON KF RUSH BD YANCEY MF STROHBACH JW THAISRIVONGS S
Citation: Kt. Chong et al., PEPTIDOMIMETIC HIV PROTEASE INHIBITORS - PHOSPHATE PRODRUGS WITH IMPROVED BIOLOGICAL-ACTIVITIES, Journal of medicinal chemistry, 36(17), 1993, pp. 2575-2577
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