AAAAAA

   
Results: 1-21 |
Results: 21
ANGIOGENESIS-DEPENDENT MODEL OF IN-SITU DUAL HINDLIMB MUSCLE FUNCTIONIN THE RABBIT
Authors: WAILGUM TD SITKO GR HOLAHAN MA HERSHEY JC COOK JC
Citation: Td. Wailgum et al., ANGIOGENESIS-DEPENDENT MODEL OF IN-SITU DUAL HINDLIMB MUSCLE FUNCTIONIN THE RABBIT, The FASEB journal, 12(4), 1998, pp. 122-122
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION
Authors: TUCKER TJ BRADY SF LUMMA WC LEWIS SD GARDELL SJ NAYLOROLSEN AM YAN YW SISKO JT STAUFFER KJ LUCAS BJ LYNCH JJ COOK JJ STRANIERI MT HOLAHAN MA LYLE EA BASKIN EP CHEN IW DANCHECK KB KRUEGER JA COOPER CM VACCA JP
Citation: Tj. Tucker et al., DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION, Journal of medicinal chemistry, 41(17), 1998, pp. 3210-3219
NONPEPTIDE GPIIB IIIA INHIBITORS .16. THIENO[2,3-B]THIOPHENE ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: PRUGH JD GOULD RJ LYNCH RJ ZHANG GX COOK JJ HOLAHAN MA STRANIERI MT SITKO GR GAUL SL BEDNAR RA BEDNAR B HARTMAN GD
Citation: Jd. Prugh et al., NONPEPTIDE GPIIB IIIA INHIBITORS .16. THIENO[2,3-B]THIOPHENE ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 865-870
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: BRASHEAR KM COOK JJ BEDNAR B BEDNAR RA GOULD RJ HALCZENKO W HOLAHAN MA LYNCH RJ HARTMAN GD HUTCHINSON JH
Citation: Km. Brashear et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2793-2798
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/
Authors: ASKEW BC MCINTYRE CJ HUNT CA CLAREMON DA BALDWIN JJ ANDERSON PS GOULD RJ LYNCH RJ CHANG CCT COOK JJ LYNCH JJ HOLAHAN MA SITKO GR STRANIERI MT
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1531-1536
EFFECTS OF PENTOBARBITAL ON PHARMACOKINETICS AND PHARMACODYNAMICS OF A POTENT FIBRINOGEN RECEPTOR ANTAGONIST, L-734217, IN DOGS
Authors: PRUEKSARITANONT T STRANIERI MT HAND EL ELLIS JD HOLAHAN MA SITKO GR COOK JJ
Citation: T. Prueksaritanont et al., EFFECTS OF PENTOBARBITAL ON PHARMACOKINETICS AND PHARMACODYNAMICS OF A POTENT FIBRINOGEN RECEPTOR ANTAGONIST, L-734217, IN DOGS, Biopharmaceutics & drug disposition, 18(8), 1997, pp. 649-663
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/
Authors: COOK JJ SITKO GR HOLAHAN MA STRANIERI MT GLASS JD ASKEW BC MCINTYRE CJ CLAREMON DA BALDWIN JJ HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 677-689
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/
Authors: ASKEW BC BEDNAR RA BEDNAR B CLAREMON DA COOK JJ MCINTYRE CJ HUNT CA GOULD RJ LYNCH RJ LYNCH JJ GAUL SL STRANIERI MT SITKO GR HOLAHAN MA GLASS JD HAMILL T GORHAM LM PRUEKSARITANONT T BALDWIN JJ HARTMAN GD
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/, Journal of medicinal chemistry, 40(12), 1997, pp. 1779-1788
NONPEPTIDE GLYCOPROTEIN IIB LIIA INHIBITORS .14. ORAL ANTITHROMBOTIC EFFICACY OF L-738,167 IN A CONSCIOUS CANINE MODEL OF CORONARY-ARTERY ELECTROLYTIC INJURY/
Authors: COOK JJ GLASS JD SITKO GR HOLAHAN MA STUPIENSKI RF WALLACE AA STUMP GL HAND EL ASKEW BC HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB LIIA INHIBITORS .14. ORAL ANTITHROMBOTIC EFFICACY OF L-738,167 IN A CONSCIOUS CANINE MODEL OF CORONARY-ARTERY ELECTROLYTIC INJURY/, Circulation, 96(3), 1997, pp. 949-958
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .12. POTENT AND ORALLY-ACTIVE CENTRALLY CONSTRAINED THIENO[2,3-C]PYRIDONES/
Authors: HALCZENKO W COOK JJ HOLAHAN MA SITKO GR STRANIERI MT ZHANG GX LYNCH RJ LYNCH JJ GOULD RJ HARTMAN GD
Citation: W. Halczenko et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .12. POTENT AND ORALLY-ACTIVE CENTRALLY CONSTRAINED THIENO[2,3-C]PYRIDONES/, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2771-2776
NONPEPTIDE GPIIB IIIA INHIBITORS .10. CENTRALLY CONSTRAINED ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: EGBERTSON MS HARTMAN GD GOULD RJ BEDNAR B BEDNAR RA COOK JJ GAUL SL HOLAHAN MA LIBBY LA LYNCH JJ LYNCH RJ SITKO GR STRANIERI MT VASSALLO LM
Citation: Ms. Egbertson et al., NONPEPTIDE GPIIB IIIA INHIBITORS .10. CENTRALLY CONSTRAINED ALPHA-SULFONAMIDES ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 6(21), 1996, pp. 2519-2524
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/
Authors: COOK JJ HOLAHAN MA LYLE EA RAMJIT DR SITKO GR STRANIERI MT STUPIENSKI RF WALLACE AA HAND EL GEHRET JR KOTHSTEIN T DRAG MD MCCORMICK GY PERKINS JJ IHLE NC DUGGAN ME HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/, The Journal of pharmacology and experimental therapeutics, 278(1), 1996, pp. 62-73
NONPEPTIDE GLYCOPROTEIN IIB IIIA ANTAGONISTS .2. DESIGN AND IN-VIVO EVALUATION OF 3,4-DIHYDRO-1(1H)-ISOQUINOLINONE-BASED ANTAGONISTS AND ETHYL-ESTER PRODRUGS/
Authors: HUTCHINSON JH COOK JJ BRASHEAR KM BRESLIN MJ GLASS JD GOULD RJ HALCZENKO W HOLAHAN MA LYNCH RJ SITKO GR STRANIERI MT HARTMAN GD
Citation: Jh. Hutchinson et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA ANTAGONISTS .2. DESIGN AND IN-VIVO EVALUATION OF 3,4-DIHYDRO-1(1H)-ISOQUINOLINONE-BASED ANTAGONISTS AND ETHYL-ESTER PRODRUGS/, Journal of medicinal chemistry, 39(23), 1996, pp. 4583-4591
INVESTIGATION OF (OXODIOXOLENYL)METHYL CARBAMATES AS NONCHIRAL BIOREVERSIBLE PRODRUG MOIETIES FOR CHIRAL AMINES
Authors: ALEXANDER J BINDRA DS GLASS JD HOLAHAN MA RENYER ML RORK GS SITKO GR STRANIERI MT STUPIENSKI RF VEERAPANANE H COOK JJ
Citation: J. Alexander et al., INVESTIGATION OF (OXODIOXOLENYL)METHYL CARBAMATES AS NONCHIRAL BIOREVERSIBLE PRODRUG MOIETIES FOR CHIRAL AMINES, Journal of medicinal chemistry, 39(2), 1996, pp. 480-486
DRUG-DEPENDENT ANTIBODIES AGAINST GPIIB IIIA INDUCE THROMBOCYTOPENIA/
Authors: BEDNAR B BEDNAR RA COOK JJ BOLLAG DM CHANG CT GAUL SL MCQUENEY PA EGBERTSON MS HARTMAN GD HOLAHAN MA LYNCH JJ GOULD RJ
Citation: B. Bednar et al., DRUG-DEPENDENT ANTIBODIES AGAINST GPIIB IIIA INDUCE THROMBOCYTOPENIA/, Circulation, 94(8), 1996, pp. 571-571
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .5. ANTITHROMBOTIC EFFECTS OF MK-0383/
Authors: LYNCH JJ COOK JJ SITKO GR HOLAHAN MA RAMJIT DR MELLOTT MJ STRANIERI MT STABILITO II ZHANG GX LYNCH RJ MANNO PD CHANG CTC EGBERTSON MS HALCZENKO W DUGGAN ME LASWELL WL VASSALLO LM SHAFER JA ANDERSON PS FRIEDMAN PA HARTMAN GD GOULD RJ
Citation: Jj. Lynch et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .5. ANTITHROMBOTIC EFFECTS OF MK-0383/, The Journal of pharmacology and experimental therapeutics, 272(1), 1995, pp. 20-32
NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS .3. DESIGN AND DISCOVERY OF A CENTRALLY CONSTRAINED INHIBITOR
Authors: EGBERTSON MS NAYLOR AM HARTMAN GD COOK JJ GOULD RJ HOLAHAN MA LYNCH JJ LYNCH RJ STRANIERI MT VASSALLO LM
Citation: Ms. Egbertson et al., NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS .3. DESIGN AND DISCOVERY OF A CENTRALLY CONSTRAINED INHIBITOR, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1835-1840
CHARACTERIZATION OF L-703,014, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST, FOLLOWING ORAL-ADMINISTRATION TO DOGS
Authors: GOULD RJ BARRETT JS ELLIS JD HOLAHAN MA STRANIERI MT THEOHARIDES AD LYNCH JJ FRIEDMAN PA DUGGAN ME IHLE NC ANDERSON PS HARTMAN GD
Citation: Rj. Gould et al., CHARACTERIZATION OF L-703,014, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST, FOLLOWING ORAL-ADMINISTRATION TO DOGS, Thrombosis and haemostasis, 69(6), 1993, pp. 539-539
THE LEECH ANTIPLATELET PROTEIN INHIBITS PLATELET-AGGREGATION BUT DOESNOT INHIBIT CYCLIC FLOW REDUCTIONS OR DELAY THE TIME TO OCCLUSION IN CANINE MODELS OF CORONARY-ARTERY THROMBOSIS
Authors: CONNOLLY TM HOLAHAN MA STABILITO II LEHMAN ED MELLOTT MJ LYNCH JJ
Citation: Tm. Connolly et al., THE LEECH ANTIPLATELET PROTEIN INHIBITS PLATELET-AGGREGATION BUT DOESNOT INHIBIT CYCLIC FLOW REDUCTIONS OR DELAY THE TIME TO OCCLUSION IN CANINE MODELS OF CORONARY-ARTERY THROMBOSIS, Thrombosis and haemostasis, 69(6), 1993, pp. 589-589
ANTITHROMBOTIC EFFECTS OF MK-0852, A PLATELET FIBRINOGEN RECEPTOR ANTAGONIST, IN CANINE MODELS OF THROMBOSIS
Authors: RAMJIT DR LYNCH JJ SITKO GR MELLOTT MJ HOLAHAN MA STABILITO II STRANIERI MT ZHANG GX LYNCH RJ MANNO PD CHANG CTC NUTT RF BRADY SF VEBER DF ANDERSON PS SHEBUSKI RJ FRIEDMAN PA GOULD RJ
Citation: Dr. Ramjit et al., ANTITHROMBOTIC EFFECTS OF MK-0852, A PLATELET FIBRINOGEN RECEPTOR ANTAGONIST, IN CANINE MODELS OF THROMBOSIS, The Journal of pharmacology and experimental therapeutics, 266(3), 1993, pp. 1501-1511
Risultati: 1-21 |