AAAAAA
Results:
1-23
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Results: 23
Authors:
Eiselt, R
Domanski, TL
Zibat, A
Mueller, R
Presecan-Siedel, E
Hustert, E
Zanger, UM
Brockmoller, J
Klenk, HP
Meyer, UA
Khan, KK
He, YA
Halpert, JR
Wojnowski, L
Citation: R. Eiselt et al., Identification and functional characterization of eight CYP3A4 protein variants, PHARMACOGEN, 11(5), 2001, pp. 447-458
Authors:
Xue, LL
Wang, HF
Wang, QM
Szklarz, GD
Domanski, TL
Halpert, JR
Correia, MA
Citation: Ll. Xue et al., Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B-1 oxidation, CHEM RES T, 14(5), 2001, pp. 483-491
Authors:
Fontaine, SM
Hoyer, PB
Halpert, JR
Sipes, IG
Citation: Sm. Fontaine et al., Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene, DRUG META D, 29(9), 2001, pp. 1236-1242
Authors:
Ferrari, L
Peng, N
Halpert, JR
Morgan, ET
Citation: L. Ferrari et al., Role of nitric oxide in down-regulation of CYP2B1 protein, but not RNA, inprimary cultures of rat hepatocytes, MOLEC PHARM, 60(1), 2001, pp. 209-216
Authors:
Spatzenegger, M
Wang, QM
He, YQ
Wester, MR
Johnson, EF
Halpert, JR
Citation: M. Spatzenegger et al., Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles, MOLEC PHARM, 59(3), 2001, pp. 475-484
Authors:
Domanski, TL
Finta, C
Halpert, JR
Zaphiropoulos, PG
Citation: Tl. Domanski et al., cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450, MOLEC PHARM, 59(2), 2001, pp. 386-392
Authors:
Domanski, TL
He, YA
Khan, KK
Roussel, F
Wang, QM
Halpert, JR
Citation: Tl. Domanski et al., Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity, BIOCHEM, 40(34), 2001, pp. 10150-10160
Authors:
Scott, EE
Spatzenegger, M
Halpert, JR
Citation: Ee. Scott et al., A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function, ARCH BIOCH, 395(1), 2001, pp. 57-68
Authors:
Domanski, TL
He, YQ
Scott, EE
Wang, QM
Halpert, JR
Citation: Tl. Domanski et al., The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins, ARCH BIOCH, 394(1), 2001, pp. 21-28
Authors:
He, YQ
Roussel, F
Halpert, JR
Citation: Yq. He et al., Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes, ARCH BIOCH, 389(2), 2001, pp. 264-270
Authors:
Domanski, TL
He, YA
Harlow, GR
Halpert, JR
Citation: Tl. Domanski et al., Dual role of human cytochrome P450 3A4 residue phe-304 in substrate specificity and cooperativity, J PHARM EXP, 293(2), 2000, pp. 585-591
Authors:
Roussel, F
Khan, KK
Halpert, JR
Citation: F. Roussel et al., The importance of SRS-1 residues in catalytic specificity of human cytochrome p450 3A4, ARCH BIOCH, 374(2), 2000, pp. 269-278
Authors:
Khan, KK
Halpert, JR
Citation: Kk. Khan et Jr. Halpert, Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes, ARCH BIOCH, 373(2), 2000, pp. 335-345
Authors:
Ourlin, JC
Baader, M
Fraser, D
Halpert, JR
Meyer, UA
Citation: Jc. Ourlin et al., Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37), ARCH BIOCH, 373(2), 2000, pp. 375-384
Authors:
Waller, SC
He, YA
Harlow, GR
He, YQ
Mash, EA
Halpert, JR
Citation: Sc. Waller et al., 2,2 ',3,3 ',6,6 '-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P4502B1 and 2B11, CHEM RES T, 12(8), 1999, pp. 690-699
Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F(1) mice
Authors:
Doerr-Stevens, JK
Liu, JP
Stevens, GJ
Kraner, JC
Fontaine, SM
Halpert, JR
Sipes, IG
Citation: Jk. Doerr-stevens et al., Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F(1) mice, DRUG META D, 27(2), 1999, pp. 281-287
Authors:
Fraser, DJ
He, YQ
Harlow, GR
Halpert, JR
Citation: Dj. Fraser et al., Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26, MOLEC PHARM, 55(2), 1999, pp. 241-247
Authors:
Domanski, TL
Schultz, KM
Roussel, F
Stevens, JC
Halpert, JR
Citation: Tl. Domanski et al., Structure-function analysis of human cytochrome P-4502B6 using a novel substrate, site-directed mutagenesis, and molecular modeling, J PHARM EXP, 290(3), 1999, pp. 1141-1147
Authors:
Stevens, JC
Domanski, TL
Harlow, GR
White, RB
Orton, E
Halpert, JR
Citation: Jc. Stevens et al., Use of the steroid derivative RPR 106541 in combination with site-directedmutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis, J PHARM EXP, 290(2), 1999, pp. 594-602
Authors:
Strobel, SM
Szklarz, GD
He, YQ
Foroozesh, M
Alworth, WL
Roberts, ES
Hollenberg, PF
Halpert, JR
Citation: Sm. Strobel et al., Identification of selective mechanism-based inactivators of cytochromes P-4502B4 and 2B5, and determination of the molecular basis for differential susceptibility, J PHARM EXP, 290(1), 1999, pp. 445-451
Authors:
Halpert, JR
Citation: Jr. Halpert, Anthony Y. H. Lu commemorative issue - Preface, DRUG META D, 26(12), 1998, pp. 1167-1167
Authors:
Szklarz, GD
Halpert, JR
Citation: Gd. Szklarz et Jr. Halpert, Molecular basis of P450 inhibition and activation - Implications for drug development and drug therapy, DRUG META D, 26(12), 1998, pp. 1179-1184
Authors:
Halpert, JR
Domanski, TL
Adali, O
Biagini, CP
Cosme, J
Dierks, EA
Johnson, EF
Jones, JP
de Montellano, PO
Philpot, RM
Sibbesen, O
Wyatt, WK
Zheng, ZP
Citation: Jr. Halpert et al., Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism, DRUG META D, 26(12), 1998, pp. 1223-1231
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