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Results: 1-25 | 26-29
Results: 1-25/29
Drug analysis based on signaling responses to G-protein-coupled receptors (Reprinted from Receptor-Based Drug Design, vol 89, pg 79-105, 1998)
Authors: Harden, TK Boyer, JL Dougherty, RW
Citation: Tk. Harden et al., Drug analysis based on signaling responses to G-protein-coupled receptors (Reprinted from Receptor-Based Drug Design, vol 89, pg 79-105, 1998), J RECEPT SI, 21(2-3), 2001, pp. 167-190
Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors
Authors: Lazarowski, ER Boucher, RC Harden, TK
Citation: Er. Lazarowski et al., Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors, DRUG DEV R, 53(2-3), 2001, pp. 66-71
Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder
Authors: Lazarowski, ER Rochelle, LG O'Neal, WK Ribeiro, CMP Grubb, BR Zhang, V Harden, TK Boucher, RC
Citation: Er. Lazarowski et al., Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder, J PHARM EXP, 297(1), 2001, pp. 43-49
Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X(1) receptors
Authors: Kim, YC Brown, SG Harden, TK Boyer, JL Dubyak, G King, BF Burnstock, G Jacobson, KA
Citation: Yc. Kim et al., Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X(1) receptors, J MED CHEM, 44(3), 2001, pp. 340-349
Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists ofthe P2Y(1) receptor: Structure-activity relationships and receptor docking
Authors: Kim, HS Barak, D Harden, TK Boyer, JL Jacobson, KA
Citation: Hs. Kim et al., Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists ofthe P2Y(1) receptor: Structure-activity relationships and receptor docking, J MED CHEM, 44(19), 2001, pp. 3092-3108
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of G alpha(11) signaling
Authors: Cunningham, ML Waldo, GL Hollinger, S Hepler, JR Harden, TK
Citation: Ml. Cunningham et al., Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of G alpha(11) signaling, J BIOL CHEM, 276(8), 2001, pp. 5438-5444
Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors - Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor
Authors: Brinson, AE Harden, TK
Citation: Ae. Brinson et Tk. Harden, Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors - Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor, J BIOL CHEM, 276(15), 2001, pp. 11939-11948
Differential coupling of the human P2Y(11) receptor to phospholipase C andadenylyl cyclase
Authors: Qi, AD Kennedy, C Harden, TK Nicholas, RA
Citation: Ad. Qi et al., Differential coupling of the human P2Y(11) receptor to phospholipase C andadenylyl cyclase, BR J PHARM, 132(1), 2001, pp. 318-326
Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein
Authors: Mutafova-Yambolieva, VN Carolan, BM Harden, TK Keef, KD
Citation: Vn. Mutafova-yambolieva et al., Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein, GEN PH-VASC, 34(2), 2000, pp. 127-136
ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor
Authors: Kennedy, C Qi, AD Herold, CL Harden, TK Nicholas, RA
Citation: C. Kennedy et al., ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor, MOLEC PHARM, 57(5), 2000, pp. 926-931
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates
Authors: Boyer, JL Delaney, SM Villaneuva, D Harden, TK
Citation: Jl. Boyer et al., A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates, MOLEC PHARM, 57(4), 2000, pp. 805-810
Characterization of contractile P2 receptors in human coronary arteries byuse of the stable pyrimidines uridine 5 '-O-thiodiphosphate and uridine 5 '-O-3-thiotriphosphate
Authors: Malmsjo, M Hou, MY Harden, TK Pendergast, W Pantev, E Edvinsson, L Erlinge, D
Citation: M. Malmsjo et al., Characterization of contractile P2 receptors in human coronary arteries byuse of the stable pyrimidines uridine 5 '-O-thiodiphosphate and uridine 5 '-O-3-thiotriphosphate, J PHARM EXP, 293(3), 2000, pp. 755-760
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands
Authors: Nandanan, E Jang, SY Moro, S Kim, HO Siddiqui, MA Russ, P Marquez, VE Busson, R Herdewijn, P Harden, TK Boyer, JL Jacobson, KA
Citation: E. Nandanan et al., Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands, J MED CHEM, 43(5), 2000, pp. 829-842
Acyclic analogues of deoxyadenosine 3 ',5 '-bisphosphates as P2Y(1) receptor antagonists
Authors: Kim, YC Gallo-Rodriguez, C Jang, SY Nandanan, E Adams, M Harden, TK Boyer, JL Jacobson, KA
Citation: Yc. Kim et al., Acyclic analogues of deoxyadenosine 3 ',5 '-bisphosphates as P2Y(1) receptor antagonists, J MED CHEM, 43(4), 2000, pp. 746-755
Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations
Authors: Lazarowski, ER Boucher, RC Harden, TK
Citation: Er. Lazarowski et al., Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations, J BIOL CHEM, 275(40), 2000, pp. 31061-31068
The stable pyrimidines UDP beta S and UTP gamma S discriminate between theP2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery
Authors: Malmsjo, M Adner, M Harden, TK Pendergast, W Edvinsson, L Erlinge, D
Citation: M. Malmsjo et al., The stable pyrimidines UDP beta S and UTP gamma S discriminate between theP2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery, BR J PHARM, 131(1), 2000, pp. 51-56
Phosphorylation by protein kinase C decreases catalytic activity of avian phospholipase C-beta
Authors: Filtz, TM Cunningham, ML Stanig, KJ Paterson, A Harden, TK
Citation: Tm. Filtz et al., Phosphorylation by protein kinase C decreases catalytic activity of avian phospholipase C-beta, BIOCHEM J, 338, 1999, pp. 257-264
Heterogeneous responses of cell Ca2+ in human airway epithelium
Authors: Paradiso, AM Brown, HA Ye, H Harden, TK Boucher, RC
Citation: Am. Paradiso et al., Heterogeneous responses of cell Ca2+ in human airway epithelium, EXP LUNG R, 25(4), 1999, pp. 277-290
Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis
Authors: Jacobson, KA Hoffmann, C Kim, YC Camaioni, E Nandanan, E Jang, SY Guo, DP Ji, XD von Kugelgen, I Moro, S Ziganshin, AU Rychkov, A King, BF Brown, SG Wildman, SS Burnstock, G Boyer, JL Mohanram, A Harden, TK
Citation: Ka. Jacobson et al., Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis, PROG BRAIN, 120, 1999, pp. 119-132
Release of ATP and UTP from astrocytoma cells
Authors: Harden, TK Lazarowski, ER
Citation: Tk. Harden et Er. Lazarowski, Release of ATP and UTP from astrocytoma cells, PROG BRAIN, 120, 1999, pp. 135-143
Protein kinase C-promoted inhibition of G alpha(11)-stimulated phospholipase C-beta activity
Authors: Cunningham, ML Filtz, TM Harden, TK
Citation: Ml. Cunningham et al., Protein kinase C-promoted inhibition of G alpha(11)-stimulated phospholipase C-beta activity, MOLEC PHARM, 56(2), 1999, pp. 265-271
Structure-activity relationships of bisphosphate nucleotide derivatives asP2Y(1) receptor antagonists and partial agonists
Authors: Nandanan, E Camaioni, E Jang, SY Kim, YC Cristalli, G Herdewijn, P Secrist, JA Tiwari, KN Mohanram, A Harden, TK Boyer, JL Jacobson, KA
Citation: E. Nandanan et al., Structure-activity relationships of bisphosphate nucleotide derivatives asP2Y(1) receptor antagonists and partial agonists, J MED CHEM, 42(9), 1999, pp. 1625-1638
Role of isoprenoid lipids on the heterotrimeric G protein gamma subunit indetermining effector activation
Authors: Myung, CS Yasuda, H Liu, WW Harden, TK Garrison, JC
Citation: Cs. Myung et al., Role of isoprenoid lipids on the heterotrimeric G protein gamma subunit indetermining effector activation, J BIOL CHEM, 274(23), 1999, pp. 16595-16603
The role of amino acids in extracellular loops of the human P2Y(1) receptor in surface expression and activation processes
Authors: Hoffmann, C Moro, S Nicholas, RA Harden, TK Jacobson, KA
Citation: C. Hoffmann et al., The role of amino acids in extracellular loops of the human P2Y(1) receptor in surface expression and activation processes, J BIOL CHEM, 274(21), 1999, pp. 14639-14647
Functional expression of a cDNA encoding a human ecto-ATPase
Authors: Mateo, J Harden, TK Boyer, JL
Citation: J. Mateo et al., Functional expression of a cDNA encoding a human ecto-ATPase, BR J PHARM, 128(2), 1999, pp. 396-402
Risultati: 1-25 | 26-29