Citation: Dl. Boger et al., Substituent effects within the DNA binding subunit of CBI analogues of theduocarmycins and CC-1065, BIOORG MED, 11(15), 2001, pp. 2021-2024
Citation: Dl. Boger et al., alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: Carbonyl group modification and alpha-substitution, BIOORG MED, 11(12), 2001, pp. 1517-1520
Authors:
Fedorova, I
Hashimoto, A
Fecik, RA
Hedrick, MP
Hanus, LO
Boger, DL
Rice, KC
Basile, AS
Citation: I. Fedorova et al., Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems, J PHARM EXP, 299(1), 2001, pp. 332-342
Citation: Dl. Boger et al., Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one alkylation subunit, J ORG CHEM, 66(7), 2001, pp. 2207-2216
Authors:
Boger, DL
Schmitt, HW
Fink, BE
Hedrick, MP
Citation: Dl. Boger et al., Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain, J ORG CHEM, 66(20), 2001, pp. 6654-6661
Citation: Dl. Boger et al., Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties, J AM CHEM S, 123(4), 2001, pp. 561-568
Authors:
Boger, DL
Fink, BE
Brunette, SR
Tse, WC
Hedrick, MP
Citation: Dl. Boger et al., A simple, high-resolution method for establishing DNA binding affinity andsequence selectivity, J AM CHEM S, 123(25), 2001, pp. 5878-5891
Authors:
Boger, DL
Dechantsreiter, MA
Ishii, T
Fink, BE
Hedrick, MP
Citation: Dl. Boger et al., Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents, BIO MED CH, 8(8), 2000, pp. 2049-2057
Citation: Dl. Boger et al., Conformationally restricted analogues designed for selective inhibition ofGAR Tfase versus thymidylate synthase or dihydrofolate reductase, BIO MED CH, 8(5), 2000, pp. 1075-1086
Citation: Dl. Boger et al., Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase, BIOORG MED, 10(13), 2000, pp. 1471-1475
Authors:
Boger, DL
Sato, H
Lerner, AE
Hedrick, MP
Fecik, RA
Miyauchi, H
Wilkie, GD
Austin, BJ
Patricelli, MP
Cravatt, BF
Citation: Dl. Boger et al., Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide, P NAS US, 97(10), 2000, pp. 5044-5049
Citation: Dl. Boger et al., Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR)reversal agents, J ORG CHEM, 65(8), 2000, pp. 2479-2483
Authors:
Boger, DL
Santillan, A
Searcey, M
Brunette, SR
Wolkenberg, SE
Hedrick, MP
Jin, Q
Citation: Dl. Boger et al., Synthesis and evaluation of 1,2,8,8a-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: Impact of the alkylation subunit substituents and its implications forDNA alkylation catalysis, J ORG CHEM, 65(13), 2000, pp. 4101-4111
Citation: Dl. Boger et al., Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents anddevelopment of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity, J AM CHEM S, 122(27), 2000, pp. 6382-6394