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Results: 1-9 |
Results: 9
3-(4-fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonist
Authors: Rowley, M Hallett, DJ Goodacre, S Moyes, C Crawforth, J Sparey, TJ Patel, S Marwood, R Patel, S Thomas, S Hitzel, L O'Connor, D Szeto, N Castro, JL Hutson, PH MacLeod, AM
Citation: M. Rowley et al., 3-(4-fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonist, J MED CHEM, 44(10), 2001, pp. 1603-1614
Use of chiral liquid chromatography-tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists
Authors: Watt, AP Hitzel, L Morrison, D Locker, KL
Citation: Ap. Watt et al., Use of chiral liquid chromatography-tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists, J CHROMAT A, 896(1-2), 2000, pp. 217-227
Determination of the in vitro metabolism of (+)- and (-)-epibatidine
Authors: Watt, AP Hitzel, L Morrison, D Locker, KL
Citation: Ap. Watt et al., Determination of the in vitro metabolism of (+)- and (-)-epibatidine, J CHROMAT A, 896(1-2), 2000, pp. 229-238
Chiral separation of 4,4-disubstituted piperidinyl substance P antagonists
Authors: Watt, AP Hitzel, L
Citation: Ap. Watt et L. Hitzel, Chiral separation of 4,4-disubstituted piperidinyl substance P antagonists, J LIQ CHR R, 23(16), 2000, pp. 2541-2552
An increased throughput method for the determination of partition coefficients
Authors: Hitzel, L Watt, AP Locker, KL
Citation: L. Hitzel et al., An increased throughput method for the determination of partition coefficients, PHARM RES, 17(11), 2000, pp. 1389-1395
An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists
Authors: Lewis, RT Ladduwahetty, T Merchant, KJ Keown, LE Hitzel, L Verrier, H Stevenson, GI MacLeod, AM
Citation: Rt. Lewis et al., An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists, J ORG CHEM, 65(8), 2000, pp. 2615-2618
Neighboring group participation of the indole nucleus: An unusual DAST-mediated rearrangement reaction
Authors: Hallett, DJ Gerhard, U Goodacre, SC Hitzel, L Sparey, TJ Thomas, S Rowley, M Ball, RG
Citation: Dj. Hallett et al., Neighboring group participation of the indole nucleus: An unusual DAST-mediated rearrangement reaction, J ORG CHEM, 65(16), 2000, pp. 4984-4993
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1A and 5-HT re-uptake ligands
Authors: van Niel, MB Beer, MS Castro, JL Cheng, SKF Evans, DC Heald, A Hitzel, L Hunt, P Mortishire-Smith, R O'Connor, D Watt, AP MacLeod, AM
Citation: Mb. Van Niel et al., Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1A and 5-HT re-uptake ligands, BIOORG MED, 9(22), 1999, pp. 3243-3248
3-[3-(Piperidin-1-yl)propyl] indoles as highly selective h5-HT1D receptor agonists
Authors: Russell, MGN Matassa, VG Pengilley, RR van Niel, MB Sohal, B Watt, AP Hitzel, L Beer, MS Stanton, JA Broughton, HB Castro, JL
Citation: Mgn. Russell et al., 3-[3-(Piperidin-1-yl)propyl] indoles as highly selective h5-HT1D receptor agonists, J MED CHEM, 42(24), 1999, pp. 4981-5001
Risultati: 1-9 |