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Results: 1-7 |
Results: 7
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors offarnesyl-protein transferase
Authors: Beshore, DC Bell, IM Dinsmore, CJ Homnick, CF Culberson, JC Robinson, RG Fernandes, C Walsh, ES Abrams, MT Bhimnathwala, HG Davide, JP Ellis-Hutchings, MS Huber, HA Koblan, KS Buser, CA Kohl, NE Lobell, RB Chen, IW McLoughlin, DA Olah, TV Graham, SL Hartman, GD Williams, TM
Citation: Dc. Beshore et al., Evaluation of amino acid-based linkers in potent macrocyclic inhibitors offarnesyl-protein transferase, BIOORG MED, 11(14), 2001, pp. 1817-1821
Design and biological activity of (S)-4-(5-{[1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency
Authors: Bell, IM Gallicchio, SN Abrams, M Beshore, DC Buser, CA Culberson, JC Davide, J Ellis-Hutchings, M Fernandes, C Gibbs, JB Graham, SL Hartman, GD Heimbrook, DC Homnick, CF Huff, JR Kassahun, K Koblan, KS Kohl, NE Lobell, RB Lynch, JJ Miller, PA Omer, CA Rodrigues, AD Walsh, ES Williams, TM
Citation: Im. Bell et al., Design and biological activity of (S)-4-(5-{[1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency, J MED CHEM, 44(18), 2001, pp. 2933-2949
Conformational restriction of flexible ligands guided by the transferred NOE experiment: Potent macrocyclic inhibitors of farnesyltransferase
Authors: Dinsmore, CJ Bogusky, MJ Culberson, JC Bergman, JM Homnick, CF Zartman, CB Mosser, SD Schaber, MD Robinson, RG Koblan, KS Huber, HE Graham, SL Hartman, GD Huff, JR Williams, TM
Citation: Cj. Dinsmore et al., Conformational restriction of flexible ligands guided by the transferred NOE experiment: Potent macrocyclic inhibitors of farnesyltransferase, J AM CHEM S, 123(9), 2001, pp. 2107-2108
Selective alpha(1a) adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones
Authors: Nantermet, PG Barrow, JC Selnick, HG Homnick, CF Freidinger, RM Chang, RSL O'Malley, SS Reiss, DR Broten, TP Ransom, RW Pettibone, DJ Olah, T Forray, C
Citation: Pg. Nantermet et al., Selective alpha(1a) adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones, BIOORG MED, 10(15), 2000, pp. 1625-1628
In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia
Authors: Barrow, JC Nantermet, PG Selnick, HG Glass, KL Rittle, KE Gilbert, KF Steele, TG Homnick, CF Freidinger, RM Ransom, RW Kling, P Reiss, D Broten, TP Schorn, TW Chang, RSL O'Malley, SS Olah, TV Ellis, JD Barrish, A Kassahun, K Leppert, P Nagarathnam, D Forray, C
Citation: Jc. Barrow et al., In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia, J MED CHEM, 43(14), 2000, pp. 2703-2718
Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation. (vol 42, pg 2409, 1999)
Authors: Egbertson, MS Cook, JJ Bednar, B Prugh, JD Bednar, RA Gaul, SL Gould, RJ Hartman, GD Homnick, CF Holahan, MA Libby, LA Lynch, JJ Lynch, RJ Sitko, GR Stranieri, MT Vasallo, LM
Citation: Ms. Egbertson et al., Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation. (vol 42, pg 2409, 1999), J MED CHEM, 42(19), 1999, pp. 4014-4014
Non-peptide GPIIb IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation
Authors: Egbertson, MS Cook, JJ Bednar, B Prugh, JD Bednar, RA Gaul, SL Gould, RJ Hartman, GD Homnick, CF Holahan, MA Libby, LA Lynch, JJ Lynch, RJ Sitko, GR Stranieri, MT Vassallo, LM
Citation: Ms. Egbertson et al., Non-peptide GPIIb IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation, J MED CHEM, 42(13), 1999, pp. 2409-2421
Risultati: 1-7 |