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Results: 1-17 |
Results: 17
USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS - CRYSTAL-STRUCTURES OF 2 PAPAIN-INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES
Authors: LALONDE JM ZHAO BG SMITH WW JANSON CA DESJARLAIS RL TOMASZEK TA CARR TJ THOMPSON SK OH HJ YAMASHITA DS VEBER DF ABDELMEGUID SS
Citation: Jm. Lalonde et al., USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS - CRYSTAL-STRUCTURES OF 2 PAPAIN-INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES, Journal of medicinal chemistry, 41(23), 1998, pp. 4567-4576
STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS CONTAINING A BENZYLOXY-SUBSTITUTED BENZOYL PEPTIDOMIMETIC
Authors: THOMPSON SK SMITH WW ZHAO BG HALBERT SM TOMASZEK TA TEW DG LEVY MA JANSON CA DALESSIO KJ MCQUENEY MS KURDYLA J JONES CS DESJARLAIS RL ABDELMEGUID SS VEBER DF
Citation: Sk. Thompson et al., STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS CONTAINING A BENZYLOXY-SUBSTITUTED BENZOYL PEPTIDOMIMETIC, Journal of medicinal chemistry, 41(21), 1998, pp. 3923-3927
CONFORMATIONALLY CONSTRAINED 1,3-DIAMINO KETONES - A SERIES OF POTENTINHIBITORS OF THE CYSTEINE PROTEASE CATHEPSIN-K
Authors: MARQUIS RW YAMASHITA DS RU Y LOCASTRO SM OH HJ ERHARD KF DESJARLAIS RL HEAD MS SMITH WW ZHAO BG JANSON CA ABDELMEGUID SS TOMASZEK TA LEVY MA VEBER DF
Citation: Rw. Marquis et al., CONFORMATIONALLY CONSTRAINED 1,3-DIAMINO KETONES - A SERIES OF POTENTINHIBITORS OF THE CYSTEINE PROTEASE CATHEPSIN-K, Journal of medicinal chemistry, 41(19), 1998, pp. 3563-3567
USE OF X-RAY CO-CRYSTAL STRUCTURES AND MOLECULAR MODELING TO DESIGN POTENT AND SELECTIVE NONPEPTIDE INHIBITORS OF CATHEPSIN-K
Authors: DESJARLAIS RL YAMASHITA DS OH HJ UZINSKAS IN ERHARD KF ALLEN AC HALTIWANGER RC ZHAO BG SMITH WW ABDELMEGUID SS DALESSIO K JANSON CA MCQUENEY MS TOMASZEK TA LEVY MA VEBER DF
Citation: Rl. Desjarlais et al., USE OF X-RAY CO-CRYSTAL STRUCTURES AND MOLECULAR MODELING TO DESIGN POTENT AND SELECTIVE NONPEPTIDE INHIBITORS OF CATHEPSIN-K, Journal of the American Chemical Society, 120(35), 1998, pp. 9114-9115
CRYSTAL-STRUCTURE OF HUMAN OSTEOCLAST CATHEPSIN-K COMPLEX WITH E-64
Authors: ZHAO BG JANSON CA AMEGADZIE BY DALESSIO K GRIFFIN C HANNING CR JONES C KURDYLA J MCQUENEY M QIU XY SMITH WW ABDELMEGUID SS
Citation: Bg. Zhao et al., CRYSTAL-STRUCTURE OF HUMAN OSTEOCLAST CATHEPSIN-K COMPLEX WITH E-64, Nature structural biology, 4(2), 1997, pp. 109-111
HUMAN CYTOMEGALOVIRUS PROTEASE - A NOVEL SERINE-PROTEASE FOLD, A UNIQUE CATALYTIC TRIAD AND AN IMPORTANT DRUG TARGET
Authors: QIU XY CULP JS DILELLA AG HELLMIG B HOOG SS JANSON CA SMITH WW ABDELMEGUID SS
Citation: Xy. Qiu et al., HUMAN CYTOMEGALOVIRUS PROTEASE - A NOVEL SERINE-PROTEASE FOLD, A UNIQUE CATALYTIC TRIAD AND AN IMPORTANT DRUG TARGET, Protein engineering, 10, 1997, pp. 52-52
CRYSTAL-STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE
Authors: QIU XY JANSON CA CULP JS RICHARDSON B DEBOUCK C SMITH WW ABDELMEGUID SS
Citation: Xy. Qiu et al., CRYSTAL-STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(7), 1997, pp. 2874-2879
DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE
Authors: THOMPSON SK HALBERT SM BOSSARD MJ TOMASZEK TA LEVY MA ZHAO BG SMITH WW ABDELMEGUID SS JANSON CA DALESSIO KJ MCQUENEY MS AMEGADZIE BY HANNING CR DESJARLAIS RL BRIAND J SARKAR SK HUDDLESTON MJ IJAMES CF CARR SA GARNES KT SHU A HEYS JR BRADBEER J ZEMBRYKI D LEERYKACZEWSKI L JAMES IE LARK MW DRAKE FH GOWEN M GLEASON JG VEBER DF
Citation: Sk. Thompson et al., DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(26), 1997, pp. 14249-14254
STRUCTURE-BASED DESIGN OF SUBSTITUTED DIPHENYL SULFONES AND SULFOXIDES AS LIPOPHILIC INHIBITORS OF THYMIDYLATE SYNTHASE
Authors: JONES TR WEBBER SE VARNEY MD REDDY MR LEWIS KK KATHARDEKAR V MAZDIYASNI H DEAL J NGUYEN D WELSH KM WEBBER S JOHNSTON A MATTHEWS DA SMITH WW JANSON CA BACQUET RJ HOWLAND EF BOOTH CLJ HERRMANN SM WARD RW WHITE J BARTLETT CA MORSE CA
Citation: Tr. Jones et al., STRUCTURE-BASED DESIGN OF SUBSTITUTED DIPHENYL SULFONES AND SULFOXIDES AS LIPOPHILIC INHIBITORS OF THYMIDYLATE SYNTHASE, Journal of medicinal chemistry, 40(5), 1997, pp. 677-683
PROTEIN STRUCTURE-BASED DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF 5-THIA-2,6-DIAMINO-4(3H)-OXOPYRIMIDINES - POTENT INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE WITH POTENT CELL-GROWTH INHIBITION
Authors: VARNEY MD PALMER CL ROMINES WH BORITZKI T MARGOSIAK SA ALMASSY R JANSON CA BARTLETT C HOWLAND EJ FERRE R
Citation: Md. Varney et al., PROTEIN STRUCTURE-BASED DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF 5-THIA-2,6-DIAMINO-4(3H)-OXOPYRIMIDINES - POTENT INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE WITH POTENT CELL-GROWTH INHIBITION, Journal of medicinal chemistry, 40(16), 1997, pp. 2502-2524
ACTIVE-SITE CAVITY OF HERPESVIRUS PROTEASES REVEALED BY THE CRYSTAL-STRUCTURE OF HERPES-SIMPLEX VIRUS PROTEASE INHIBITOR COMPLEX/
Authors: HOOG SS SMITH WW QIU XY JANSON CA HELLMIG B MCQUENEY MS ODONNELL K OSHANNESSY D DILELLA AG DEBOUCK C ABDELMEGUID SS
Citation: Ss. Hoog et al., ACTIVE-SITE CAVITY OF HERPESVIRUS PROTEASES REVEALED BY THE CRYSTAL-STRUCTURE OF HERPES-SIMPLEX VIRUS PROTEASE INHIBITOR COMPLEX/, Biochemistry, 36(46), 1997, pp. 14023-14029
STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS
Authors: YAMASHITA DS SMITH WW ZHAO BG JANSON CA TOMASZEK TA BOSSARD MJ LEVY MA OH HJ CARR TJ THOMPSON SK IJAMES CF CARR SA MCQUENEY M DALESSIO KJ AMEGADZIE BY HANNING CR ABDELMEGUID S DESJARLAIS RL GLEASON JG VEBER DF
Citation: Ds. Yamashita et al., STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS, Journal of the American Chemical Society, 119(46), 1997, pp. 11351-11352
UNIQUE FOLD AND ACTIVE-SITE IN CYTOMEGALOVIRUS PROTEASE
Authors: QIU XY CULP JS DILELLA AG HELLMIG B HOOG SS JANSON CA SMITH WW ABDELMEGUID SS
Citation: Xy. Qiu et al., UNIQUE FOLD AND ACTIVE-SITE IN CYTOMEGALOVIRUS PROTEASE, Nature, 383(6597), 1996, pp. 275-279
STRUCTURE-BASED DESIGN OF LIPOPHILIC QUINAZOLINE INHIBITORS OF THYMIDYLATE SYNTHASE
Authors: JONES TR VARNEY MD WEBBER SE LEWIS KK MARZONI GP PALMER CL KATHARDEKAR V WELSH KM WEBBER S MATTHEWS DA APPELT K SMITH WW JANSON CA VILLAFRANCA JE BACQUET RJ HOWLAND EF BOOTH CLJ HERRMANN SM WARD RW WHITE J MOOMAW EW BARTLETT CA MORSE CA
Citation: Tr. Jones et al., STRUCTURE-BASED DESIGN OF LIPOPHILIC QUINAZOLINE INHIBITORS OF THYMIDYLATE SYNTHASE, Journal of medicinal chemistry, 39(4), 1996, pp. 904-917
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 2,6-DIAMINOBENZ[CD]INDOLE INHIBITORS OF THYMIDYLATE SYNTHASE USING THE PROTEIN-STRUCTURE AS A GUIDE
Authors: VARNEY MD PALMER CL DEAL JG WEBBER S WELSH KM BARTLETT CA MORSE CA SMITH WW JANSON CA
Citation: Md. Varney et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 2,6-DIAMINOBENZ[CD]INDOLE INHIBITORS OF THYMIDYLATE SYNTHASE USING THE PROTEIN-STRUCTURE AS A GUIDE, Journal of medicinal chemistry, 38(11), 1995, pp. 1892-1903
STRUCTURE OF AND KINETIC CHANNELING IN BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
Authors: KNIGHTON DR KAN CC HOWLAND E JANSON CA HOSTOMSKA Z WELSCH KM MATTHEWS DA
Citation: Dr. Knighton et al., STRUCTURE OF AND KINETIC CHANNELING IN BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE, Nature structural biology, 1(3), 1994, pp. 186-194
STRUCTURE OF HUMAN RHINOVIRUS 3C PROTEASE REVEALS A TRYPSIN-LIKE POLYPEPTIDE FOLD, RNA-BINDING SITE, AND MEANS FOR CLEAVING PRECURSOR POLYPROTEIN
Authors: MATTHEWS DA SMITH WW FERRE RA CONDON B BUDAHAZI G SISSON W VILLAFRANCA JE JANSON CA MCELROY HE GRIBSKOV CL WORLAND S
Citation: Da. Matthews et al., STRUCTURE OF HUMAN RHINOVIRUS 3C PROTEASE REVEALS A TRYPSIN-LIKE POLYPEPTIDE FOLD, RNA-BINDING SITE, AND MEANS FOR CLEAVING PRECURSOR POLYPROTEIN, Cell, 77(5), 1994, pp. 761-771
Risultati: 1-17 |