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Results: 1-24 |
Results: 24
SYNTHESIS AND TYROSINE KINASE INHIBITORY ACTIVITY OF A SERIES OF 2-AMINO-8H-PYRIDO[2,3-D]PYRIMIDINES - IDENTIFICATION OF POTENT, SELECTIVE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITORS
Authors: BOSCHELLI DH WU ZP KLUTCHKO SR SHOWALTER HDH HAMBY JM LU GH MAJOR TC DAHRING TK BATLEY B PANEK RL KEISER J HARTL BG KRAKER AJ KLOHS WD ROBERTS BJ PATMORE S ELLIOTT WL STEINKAMPF R BRADFORD LA HALLAK H DOHERTY AM
Citation: Dh. Boschelli et al., SYNTHESIS AND TYROSINE KINASE INHIBITORY ACTIVITY OF A SERIES OF 2-AMINO-8H-PYRIDO[2,3-D]PYRIMIDINES - IDENTIFICATION OF POTENT, SELECTIVE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITORS, Journal of medicinal chemistry, 41(22), 1998, pp. 4365-4377
2-SUBSTITUTED AMINOPYRIDO[2,3-D]PYRIMIDIN-7(8H) ONES - STRUCTURE-ACTIVITY-RELATIONSHIPS AGAINST SELECTED TYROSINE KINASES AND IN-VITRO AND IN-VIVO ANTICANCER ACTIVITY
Authors: KLUTCHKO SR HAMBY JM BOSCHELLI DH WU ZP KRAKER AJ AMAR AM HARTL BG SHEN C KLOHS WD STEINKAMPF RW DRISCOLL DL NELSON JM ELLIOTT WL ROBERTS BJ STONER CL VINCENT PW DYKES DJ PANEK RL LU GH MAJOR TC DAHRING TK HALLAK H BRADFORD LA SHOWALTER HDH DOHERTY AM
Citation: Sr. Klutchko et al., 2-SUBSTITUTED AMINOPYRIDO[2,3-D]PYRIMIDIN-7(8H) ONES - STRUCTURE-ACTIVITY-RELATIONSHIPS AGAINST SELECTED TYROSINE KINASES AND IN-VITRO AND IN-VIVO ANTICANCER ACTIVITY, Journal of medicinal chemistry, 41(17), 1998, pp. 3276-3292
ROLE OF TYROSINE KINASE-ACTIVITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN THE LYSOPHOSPHATIDIC ACID-STIMULATED MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAY
Authors: CUNNICK JM DORSEY JF STANDLEY T TURKSON J KRAKER AJ FRY DW JOVE R WU J
Citation: Jm. Cunnick et al., ROLE OF TYROSINE KINASE-ACTIVITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN THE LYSOPHOSPHATIDIC ACID-STIMULATED MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAY, The Journal of biological chemistry, 273(23), 1998, pp. 14468-14475
1-OXO-3-ARYL-1H-INDENE-2-CARBOXYLIC ACID-DERIVATIVES AS SELECTIVE INHIBITORS OF FIBROBLAST GROWTH-FACTOR RECEPTOR-1 TYROSINE KINASE
Authors: BARVIAN MR PANEK RL LU GH KRAKER AJ AMAR A HARTL B HAMBY JM SHOWALTER HDH
Citation: Mr. Barvian et al., 1-OXO-3-ARYL-1H-INDENE-2-CARBOXYLIC ACID-DERIVATIVES AS SELECTIVE INHIBITORS OF FIBROBLAST GROWTH-FACTOR RECEPTOR-1 TYROSINE KINASE, Bioorganic & medicinal chemistry letters, 7(22), 1997, pp. 2903-2908
DISCOVERY AND STRUCTURE-ACTIVITY STUDIES OF A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS
Authors: CONNOLLY CJC HAMBY JM SCHROEDER MC BARVIAN M LU GH PANEK RL AMAR A SHEN C KRAKER AJ FRY DW KLOHS WD DOHERTY AM
Citation: Cjc. Connolly et al., DISCOVERY AND STRUCTURE-ACTIVITY STUDIES OF A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS, Bioorganic & medicinal chemistry letters, 7(18), 1997, pp. 2415-2420
SMALL-MOLECULE INHIBITORS OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR, THE FIBROBLAST GROWTH-FACTOR RECEPTOR, AND SRC FAMILY TYROSINE KINASES
Authors: SHOWALTER HDH KRAKER AJ
Citation: Hdh. Showalter et Aj. Kraker, SMALL-MOLECULE INHIBITORS OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR, THE FIBROBLAST GROWTH-FACTOR RECEPTOR, AND SRC FAMILY TYROSINE KINASES, Pharmacology & therapeutics, 76(1-3), 1997, pp. 55-71
INHIBITION OF GROWTH FACTOR-MEDIATED TYROSINE PHOSPHORYLATION IN VASCULAR SMOOTH-MUSCLE BY PD-089828, A NEW SYNTHETIC PROTEIN-TYROSINE KINASE INHIBITOR
Authors: DAHRING TK LU GH HAMBY JM BATLEY BL KRAKER AJ PANEK RL
Citation: Tk. Dahring et al., INHIBITION OF GROWTH FACTOR-MEDIATED TYROSINE PHOSPHORYLATION IN VASCULAR SMOOTH-MUSCLE BY PD-089828, A NEW SYNTHETIC PROTEIN-TYROSINE KINASE INHIBITOR, The Journal of pharmacology and experimental therapeutics, 281(3), 1997, pp. 1446-1456
TYROSINE KINASE INHIBITORS .6. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DISELENOBIS(1H-INDOLES) FOR INHIBITION OF PROTEIN-TYROSINE KINASES AND COMPARATIVE IN-VITRO AND IN-VIVO STUDIES AGAINST SELECTED SULFUR CONGENERS
Authors: SHOWALTER HDH SERCEL AD LEJA BM WOLFANGEL CD AMBROSO LA ELLIOTT WL FRY DW KRAKER AJ HOWARD CT LU GH MOORE CW NELSON JM ROBERTS BJ VINCENT PW DENNY WA THOMPSON AM
Citation: Hdh. Showalter et al., TYROSINE KINASE INHIBITORS .6. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DISELENOBIS(1H-INDOLES) FOR INHIBITION OF PROTEIN-TYROSINE KINASES AND COMPARATIVE IN-VITRO AND IN-VIVO STUDIES AGAINST SELECTED SULFUR CONGENERS, Journal of medicinal chemistry, 40(4), 1997, pp. 413-426
STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS
Authors: HAMBY JM CONNOLLY CJC SCHROEDER MC WINTERS RT SHOWALTER HDH PANEK RL MAJOR TC OLSEWSKI B RYAN MJ DAHRING T LU GH KEISER J AMAR A SHEN C KRAKER AJ SLINTAK V NELSON JM FRY DW BRADFORD L HALLAK H DOHERTY AM
Citation: Jm. Hamby et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A NOVEL SERIES OF PYRIDO[2,3-D]PYRIMIDINE TYROSINE KINASE INHIBITORS, Journal of medicinal chemistry, 40(15), 1997, pp. 2296-2303
SYNTHESIS OF C-5 BENZOYL AND AZIDO FUNCTIONALIZED 2,2'-DITHIOBIS-(1H-INDOLE) AND 2,2'-DISELENOBIS(1H-INDOLE)
Authors: SUN L RUBIN JR KRAKER AJ SHOWALTER HDH
Citation: L. Sun et al., SYNTHESIS OF C-5 BENZOYL AND AZIDO FUNCTIONALIZED 2,2'-DITHIOBIS-(1H-INDOLE) AND 2,2'-DISELENOBIS(1H-INDOLE), Journal of heterocyclic chemistry, 34(5), 1997, pp. 1399-1405
STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 4-ANILINOQUINAZOLINES AS POTENT INHIBITORS AT THE ATP BINDING-SITE OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN-VITRO
Authors: DENNY WA REWCASTLE GW BRIDGES AJ FRY DW KRAKER AJ
Citation: Wa. Denny et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 4-ANILINOQUINAZOLINES AS POTENT INHIBITORS AT THE ATP BINDING-SITE OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN-VITRO, Clinical and experimental pharmacology and physiology, 23(5), 1996, pp. 424-427
TYROSINE KINASE INHIBITORS .9. SYNTHESIS AND EVALUATION OF FUSED TRICYCLIC QUINAZOLINE ANALOGS AS ATP SITE INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: REWCASTLE GW PALMER BD BRIDGES AJ SHOWALTER HDH LI S NELSON J MCMICHAEL A KRAKER AJ FRY DW DENNY WA
Citation: Gw. Rewcastle et al., TYROSINE KINASE INHIBITORS .9. SYNTHESIS AND EVALUATION OF FUSED TRICYCLIC QUINAZOLINE ANALOGS AS ATP SITE INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 39(4), 1996, pp. 918-928
TYROSINE KINASE INHIBITORS .8. AN UNUSUALLY STEEP STRUCTURE-ACTIVITY RELATIONSHIP FOR ANALOGS OF 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE (PD-153035), A POTENT INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: BRIDGES AJ ZHOU H CODY DR REWCASTLE GW MCMICHAEL A SHOWALTER HDH FRY DW KRAKER AJ DENNY WA
Citation: Aj. Bridges et al., TYROSINE KINASE INHIBITORS .8. AN UNUSUALLY STEEP STRUCTURE-ACTIVITY RELATIONSHIP FOR ANALOGS OF 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE (PD-153035), A POTENT INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 39(1), 1996, pp. 267-276
TYROSINE KINASE INHIBITORS .7. 7-AMINO-4-(PHENYLAMINO)PYRIDO[4,3-D]PYRIMIDINES AND NO-4-[(PHENYLMETHYL)AMINO]PYRIDO[4,3-D]PYRIMIDINES - A NEW CLASS OF INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: THOMPSON AM BRIDGES AJ FRY DW KRAKER AJ DENNY WA
Citation: Am. Thompson et al., TYROSINE KINASE INHIBITORS .7. 7-AMINO-4-(PHENYLAMINO)PYRIDO[4,3-D]PYRIMIDINES AND NO-4-[(PHENYLMETHYL)AMINO]PYRIDO[4,3-D]PYRIMIDINES - A NEW CLASS OF INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 38(19), 1995, pp. 3780-3788
TYROSINE KINASE INHIBITORS .4. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DITHIOBIS(1H-INDOLES) FOR IN-VITRO INHIBITION OF RECEPTOR AND NONRECEPTOR PROTEIN-TYROSINE KINASES
Authors: PALMER BD REWCASTLE GW THOMPSON AM BOYD M SHOWALTER HDH SERCEL AD FRY DW KRAKER AJ DENNY WA
Citation: Bd. Palmer et al., TYROSINE KINASE INHIBITORS .4. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DITHIOBIS(1H-INDOLES) FOR IN-VITRO INHIBITION OF RECEPTOR AND NONRECEPTOR PROTEIN-TYROSINE KINASES, Journal of medicinal chemistry, 38(1), 1995, pp. 58-67
ROLE OF A SMALL MOLECULAR-WEIGHT PHOSPHOPROTEIN IN THE MECHANISM OF ACTION OF CI-994 (N-ACETYLDINALINE)
Authors: RUMMEL SA KRAKER AJ STEINKAMPF RW HOOK KE KLOHS WD
Citation: Sa. Rummel et al., ROLE OF A SMALL MOLECULAR-WEIGHT PHOSPHOPROTEIN IN THE MECHANISM OF ACTION OF CI-994 (N-ACETYLDINALINE), International journal of cancer, 62(5), 1995, pp. 636-642
STRATEGIES FOR THE DISCOVERY OF NOVEL TYROSINE KINASE INHIBITORS WITHANTICANCER ACTIVITY
Authors: FRY DW KRAKER AJ CONNERS RC ELLIOTT WL NELSON JM SHOWALTER HDH LEOPOLD WR
Citation: Dw. Fry et al., STRATEGIES FOR THE DISCOVERY OF NOVEL TYROSINE KINASE INHIBITORS WITHANTICANCER ACTIVITY, Anti-cancer drug design, 9(4), 1994, pp. 331-351
BASAL METALLOTHIONEIN IN TUMORS - WIDESPREAD PRESENCE OF APOPROTEIN
Authors: PATTANAIK A SHAW CF PETERING DH GARVEY J KRAKER AJ
Citation: A. Pattanaik et al., BASAL METALLOTHIONEIN IN TUMORS - WIDESPREAD PRESENCE OF APOPROTEIN, Journal of inorganic biochemistry, 54(2), 1994, pp. 91-105
A SPECIFIC INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINEKINASE
Authors: FRY DW KRAKER AJ MCMICHAEL A AMBROSO LA NELSON JM LEOPOLD WR CONNERS RW BRIDGES AJ
Citation: Dw. Fry et al., A SPECIFIC INHIBITOR OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINEKINASE, Science, 265(5175), 1994, pp. 1093-1095
TYROSINE KINASE INHIBITORS .2. SYNTHESIS OF 2,2'-DITHIOBIS(1H-INDOLE-3-ALKANAMIDES) AND INVESTIGATION OF THEIR INHIBITORY ACTIVITY AGAINST EPIDERMAL GROWTH-FACTOR RECEPTOR AND PP60(V-SRC) PROTEIN-TYROSINE KINASES
Authors: THOMPSON AM FRY DW KRAKER AJ DENNY WA
Citation: Am. Thompson et al., TYROSINE KINASE INHIBITORS .2. SYNTHESIS OF 2,2'-DITHIOBIS(1H-INDOLE-3-ALKANAMIDES) AND INVESTIGATION OF THEIR INHIBITORY ACTIVITY AGAINST EPIDERMAL GROWTH-FACTOR RECEPTOR AND PP60(V-SRC) PROTEIN-TYROSINE KINASES, Journal of medicinal chemistry, 37(5), 1994, pp. 598-609
SYNTHESIS AND BIOCHEMICAL EVALUATION OF A SERIES OF AMINOFLAVONES AS POTENTIAL INHIBITORS OF PROTEIN-TYROSINE KINASES P56(LCK), EGFR, AND P60(V-SRC)
Authors: CUSHMAN M ZHU H GEAHLEN RL KRAKER AJ
Citation: M. Cushman et al., SYNTHESIS AND BIOCHEMICAL EVALUATION OF A SERIES OF AMINOFLAVONES AS POTENTIAL INHIBITORS OF PROTEIN-TYROSINE KINASES P56(LCK), EGFR, AND P60(V-SRC), Journal of medicinal chemistry, 37(20), 1994, pp. 3353-3362
SYNTHESIS, STRUCTURAL CHARACTERIZATION, AND ANTITUMOR PROPERTIES OF ANOVEL CLASS OF LARGE-RING PLATINUM(II) CHELATE COMPLEXES INCORPORATING THE CIS-1,4-DIAMINOCYCLOHEXANE LIGAND IN A UNIQUE LOCKED BOAT CONFORMATION
Authors: HOESCHELE JD SHOWALTER HDH KRAKER AJ ELLIOTT WL ROBERTS BJ KAMPF JW
Citation: Jd. Hoeschele et al., SYNTHESIS, STRUCTURAL CHARACTERIZATION, AND ANTITUMOR PROPERTIES OF ANOVEL CLASS OF LARGE-RING PLATINUM(II) CHELATE COMPLEXES INCORPORATING THE CIS-1,4-DIAMINOCYCLOHEXANE LIGAND IN A UNIQUE LOCKED BOAT CONFORMATION, Journal of medicinal chemistry, 37(17), 1994, pp. 2630-2636
TYROSINE KINASE INHIBITORS .3. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR INHIBITION OF PROTEIN-TYROSINE KINASES BY NUCLEAR-SUBSTITUTED DERIVATIVES OF THIOBIS(1-METHYL-N-PHENYL-1H-INDOLE-3-CARBOXAMIDE)
Authors: REWCASTLE GW PALMER BD DOBRUSIN EM FRY DW KRAKER AJ DENNY WA
Citation: Gw. Rewcastle et al., TYROSINE KINASE INHIBITORS .3. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR INHIBITION OF PROTEIN-TYROSINE KINASES BY NUCLEAR-SUBSTITUTED DERIVATIVES OF THIOBIS(1-METHYL-N-PHENYL-1H-INDOLE-3-CARBOXAMIDE), Journal of medicinal chemistry, 37(13), 1994, pp. 2033-2042
TYROSINE KINASE INHIBITORS .1. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR INHIBITION OF EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE KINASE-ACTIVITYBY 2,3-DIHYDRO-2-THIOXO-1H-INDOLE-3-ALKANOIC ACIDS AND 2,2'-DITHIOBIS(1H-INDOLE-3-ALKANOIC ACIDS)
Authors: THOMPSON AM REWCASTLE GW TERCEL M DOBRUSIN EM FRY DW KRAKER AJ DENNY WA
Citation: Am. Thompson et al., TYROSINE KINASE INHIBITORS .1. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR INHIBITION OF EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE KINASE-ACTIVITYBY 2,3-DIHYDRO-2-THIOXO-1H-INDOLE-3-ALKANOIC ACIDS AND 2,2'-DITHIOBIS(1H-INDOLE-3-ALKANOIC ACIDS), Journal of medicinal chemistry, 36(17), 1993, pp. 2459-2469
Risultati: 1-24 |