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Results: 1-25 | 26-28
Results: 1-25/28
Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism
Authors: Willson, TM Jones, SA Moore, JT Kliewer, SA
Citation: Tm. Willson et al., Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism, MED RES REV, 21(6), 2001, pp. 513-522
Peroxisome proliferator-activated receptors: From genes to physiology
Authors: Kliewer, SA Xu, HE Lambert, MH Willson, TM
Citation: Sa. Kliewer et al., Peroxisome proliferator-activated receptors: From genes to physiology, REC PROG H, 56, 2001, pp. 239-263
Peroxisome proliferator-activated receptor gamma and metabolic disease
Authors: Willson, TM Lambert, MH Kliewer, SA
Citation: Tm. Willson et al., Peroxisome proliferator-activated receptor gamma and metabolic disease, ANN R BIOCH, 70, 2001, pp. 341-367
The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
Authors: Watkins, RE Wisely, GB Moore, LB Collins, JL Lambert, MH Williams, SP Willson, TM Kliewer, SA Redinbo, MR
Citation: Re. Watkins et al., The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity, SCIENCE, 292(5525), 2001, pp. 2329-2333
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
Authors: Oliver, WR Shenk, JL Snaith, MR Russell, CS Plunket, KD Bodkin, NL Lewis, MC Winegar, DA Sznaidman, ML Lambert, MH Xu, HE Sternbach, DD Kliewer, SA Hansen, BC Willson, TM
Citation: Wr. Oliver et al., A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport, P NAS US, 98(9), 2001, pp. 5306-5311
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
Authors: Staudinger, JL Goodwin, B Jones, SA Hawkins-Brown, D MacKenzie, KI Latour, A Liu, YP Klaassen, CD Brown, KK Reinhard, J Willson, TN Koller, BH Kliewer, SA
Citation: Jl. Staudinger et al., The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity, P NAS US, 98(6), 2001, pp. 3369-3374
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
Authors: Xu, HE Lambert, MH Montana, VG Plunket, KD Moore, LB Collins, JB Oplinger, JA Kliewer, SA Gampe, RT McKee, DD Moore, JT Willson, TM
Citation: He. Xu et al., Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors, P NAS US, 98(24), 2001, pp. 13919-13924
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor
Authors: Goodwin, B Moore, LB Stoltz, CM McKee, DD Kliewer, SA
Citation: B. Goodwin et al., Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor, MOLEC PHARM, 60(3), 2001, pp. 427-431
Effects of fenofibrate on lipid parameters in obese rhesus monkeys
Authors: Winegar, DA Brown, PJ Wilkison, WO Lewis, MC Ott, RJ Tong, WQ Brown, HR Lehmann, JM Kliewer, SA Plunket, KD Way, JM Bodkin, NL Hansen, BC
Citation: Da. Winegar et al., Effects of fenofibrate on lipid parameters in obese rhesus monkeys, J LIPID RES, 42(10), 2001, pp. 1543-1551
Liver X receptor (LXR) regulation of the LMR alpha gene in human macrophages
Authors: Whitney, KD Watson, MA Goodwin, B Galardi, CM Maglich, JM Wilson, JG Willson, TM Collins, JL Kliewer, SA
Citation: Kd. Whitney et al., Liver X receptor (LXR) regulation of the LMR alpha gene in human macrophages, J BIOL CHEM, 276(47), 2001, pp. 43509-43515
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists
Authors: Way, JM Gorgun, CZ Tong, Q Uysal, KT Brown, KK Harrington, WW Oliver, WR Willson, TM Kliewer, SA Hotamisligil, GS
Citation: Jm. Way et al., Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists, J BIOL CHEM, 276(28), 2001, pp. 25651-25653
Comprehensive messenger ribonucleic acid profiling reveals that peroxisomeproliferator-activated receptor gamma activation has coordinate effects ongene expression in multiple insulin-sensitive tissues
Authors: Way, JM Harrington, WW Brown, KK Gottschalk, WK Sundseth, SS Mansfield, TA Ramachandran, RK Willson, TM Kliewer, SA
Citation: Jm. Way et al., Comprehensive messenger ribonucleic acid profiling reveals that peroxisomeproliferator-activated receptor gamma activation has coordinate effects ongene expression in multiple insulin-sensitive tissues, ENDOCRINOL, 142(3), 2001, pp. 1269-1277
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Authors: Goodwin, B Jones, SA Price, RR Watson, MA McKee, DD Moore, LB Galardi, C Wilson, JG Lewis, MC Roth, ME Maloney, PR Willson, TM Kliewer, SA
Citation: B. Goodwin et al., A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis, MOL CELL, 6(3), 2000, pp. 517-526
Asymmetry in the PPAR gamma/RXR alpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
Authors: Gampe, RT Montana, VG Lambert, MH Miller, AB Bledsoe, RK Milburn, MV Kliewer, SA Willson, TM Xu, HE
Citation: Rt. Gampe et al., Asymmetry in the PPAR gamma/RXR alpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors, MOL CELL, 5(3), 2000, pp. 545-555
Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype
Authors: Takada, I Yu, RT Xu, HE Lambert, MH Montana, VG Kliewer, SA Evans, RM Umesono, K
Citation: I. Takada et al., Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype, MOL ENDOCR, 14(5), 2000, pp. 733-740
The pregnane x receptor: A promiscuous xenobiotic receptor that has diverged during evolution
Authors: Jones, SA Moore, LB Shenk, JL Wisely, GB Hamilton, GA McKee, DD Tomkinson, NCO LeCluyse, EL Lambert, MH Willson, TM Kliewer, SA Moore, JT
Citation: Sa. Jones et al., The pregnane x receptor: A promiscuous xenobiotic receptor that has diverged during evolution, MOL ENDOCR, 14(1), 2000, pp. 27-39
Use of the nuclear receptor PXR to predict drug interactions
Authors: Moore, JT Kliewer, SA
Citation: Jt. Moore et Sa. Kliewer, Use of the nuclear receptor PXR to predict drug interactions, TOXICOLOGY, 153(1-3), 2000, pp. 1-10
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
Authors: Moore, LB Goodwin, B Jones, SA Wisely, GB Serabjit-Singh, CJ Willson, TM Collins, JL Kliewer, SA
Citation: Lb. Moore et al., St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor, P NAS US, 97(13), 2000, pp. 7500-7502
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
Authors: Moore, LB Parks, DJ Jones, SA Bledsoe, RK Consler, TG Stimmel, JB Goodwin, B Liddle, C Blanchard, SG Willson, TM Collins, JL Kliewer, SA
Citation: Lb. Moore et al., Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands, J BIOL CHEM, 275(20), 2000, pp. 15122-15127
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Authors: Xu, HE Lambert, MH Montana, VG Parks, DJ Blanchard, SG Brown, PJ Sternbach, DD Lehmann, JM Wisely, GB Willson, TM Kliewer, SA Milburn, MV
Citation: He. Xu et al., Molecular recognition of fatty acids by peroxisome proliferator-activated receptors, MOL CELL, 3(3), 1999, pp. 397-403
Bile acids: Natural ligands for an orphan nuclear receptor
Authors: Parks, DJ Blanchard, SG Bledsoe, RK Chandra, G Consler, TG Kliewer, SA Stimmel, JB Willson, TM Zavacki, AM Moore, DD Lehmann, JM
Citation: Dj. Parks et al., Bile acids: Natural ligands for an orphan nuclear receptor, SCIENCE, 284(5418), 1999, pp. 1365-1368
Orphan nuclear receptors: Shifting endocrinology into reverse
Authors: Kliewer, SA Lehmann, JM Willson, TM
Citation: Sa. Kliewer et al., Orphan nuclear receptors: Shifting endocrinology into reverse, SCIENCE, 284(5415), 1999, pp. 757-760
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation
Authors: Oberfield, JL Collins, JL Holmes, CP Goreham, DM Cooper, JP Cobb, JE Lenhard, JM Hull-Ryde, EA Mohr, CP Blanchard, SG Parks, DJ Moore, LB Lehmann, JM Plunket, K Miller, AB Milburn, MV Kliewer, SA Willson, TM
Citation: Jl. Oberfield et al., A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation, P NAS US, 96(11), 1999, pp. 6102-6106
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXR beta
Authors: Janowski, BA Grogan, MJ Jones, SA Wisely, GB Kliewer, SA Corey, EJ Mangelsdorf, DJ
Citation: Ba. Janowski et al., Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXR beta, P NAS US, 96(1), 1999, pp. 266-271
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPAR alpha agonist with potent lipid-lowering activity
Authors: Brown, PJ Winegar, DA Plunket, KD Moore, LB Lewis, MC Wilson, JG Sundseth, SS Koble, CS Wu, ZD Chapman, JM Lehmann, JM Kliewer, SA Willson, TM
Citation: Pj. Brown et al., A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPAR alpha agonist with potent lipid-lowering activity, J MED CHEM, 42(19), 1999, pp. 3785-3788
Risultati: 1-25 | 26-28