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Results: 1-18 |
Results: 18
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase
Authors: Dinsmore, CJ Bergman, JM Wei, DD Zartman, CB Davide, JP Greenberg, IB Liu, DM O'Neill, TJ Gibbs, JB Koblan, KS Kohl, NE Lobell, RB Chen, IW McLoughlin, DA Olah, TV Graham, SL Hartman, GD Williams, TM
Citation: Cj. Dinsmore et al., Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase, BIOORG MED, 11(4), 2001, pp. 537-540
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors offarnesyl-protein transferase
Authors: Beshore, DC Bell, IM Dinsmore, CJ Homnick, CF Culberson, JC Robinson, RG Fernandes, C Walsh, ES Abrams, MT Bhimnathwala, HG Davide, JP Ellis-Hutchings, MS Huber, HA Koblan, KS Buser, CA Kohl, NE Lobell, RB Chen, IW McLoughlin, DA Olah, TV Graham, SL Hartman, GD Williams, TM
Citation: Dc. Beshore et al., Evaluation of amino acid-based linkers in potent macrocyclic inhibitors offarnesyl-protein transferase, BIOORG MED, 11(14), 2001, pp. 1817-1821
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Authors: Bergman, JM Abrams, MT Davide, JP Greenberg, IB Robinson, RG Buser, CA Huber, HE Koblan, KS Kohl, NE Lobell, RB Graham, SL Hartman, GD Williams, TM Dinsmore, CJ
Citation: Jm. Bergman et al., Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I, BIOORG MED, 11(11), 2001, pp. 1411-1415
Diaryl ether inhibitors of farnesyl-protein transferase
Authors: MacTough, SC DeSolms, SJ Shaw, AW Abrams, MT Ciccarone, TR Davide, JP Hamilton, KA Hutchinson, JH Koblan, KS Kohl, NE Lobell, RB Robinson, RG Graham, SL
Citation: Sc. Mactough et al., Diaryl ether inhibitors of farnesyl-protein transferase, BIOORG MED, 11(10), 2001, pp. 1257-1260
Cloning, characterization and distribution of receptor activity central nervous system modifying proteins in the rat
Authors: Oliver, KR Kane, SA Salvatore, CA Mallee, JJ Kinsey, AM Koblan, KS Keyvan-Fouladi, N Heavens, RP Wainwright, A Jacobson, M Dickerson, IM Hill, RG
Citation: Kr. Oliver et al., Cloning, characterization and distribution of receptor activity central nervous system modifying proteins in the rat, EUR J NEURO, 14(4), 2001, pp. 618-628
Functional role of alpha-calcitonin gene-related peptide in the regulationof the cardiovascular system
Authors: Shen, YT Pittman, TJ Buie, PS Bolduc, DL Kane, SA Koblan, KS Gould, RJ Lynch, JJ
Citation: Yt. Shen et al., Functional role of alpha-calcitonin gene-related peptide in the regulationof the cardiovascular system, J PHARM EXP, 298(2), 2001, pp. 551-558
Design and biological activity of (S)-4-(5-{[1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency
Authors: Bell, IM Gallicchio, SN Abrams, M Beshore, DC Buser, CA Culberson, JC Davide, J Ellis-Hutchings, M Fernandes, C Gibbs, JB Graham, SL Hartman, GD Heimbrook, DC Homnick, CF Huff, JR Kassahun, K Koblan, KS Kohl, NE Lobell, RB Lynch, JJ Miller, PA Omer, CA Rodrigues, AD Walsh, ES Williams, TM
Citation: Im. Bell et al., Design and biological activity of (S)-4-(5-{[1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency, J MED CHEM, 44(18), 2001, pp. 2933-2949
Characterisation of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries
Authors: Edvinsson, L Sams, A Jansen-Olesen, I Tajti, J Kane, SA Rutledge, RZ Koblan, KS Hill, RG Longmore, J
Citation: L. Edvinsson et al., Characterisation of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries, EUR J PHARM, 415(1), 2001, pp. 39-44
High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123
Authors: Buser, CA Dinsmore, CJ Fernandes, C Greenberg, I Hamilton, K Mosser, SD Walsh, ES Williams, TM Koblan, KS
Citation: Ca. Buser et al., High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123, ANALYT BIOC, 290(1), 2001, pp. 126-137
Conformational restriction of flexible ligands guided by the transferred NOE experiment: Potent macrocyclic inhibitors of farnesyltransferase
Authors: Dinsmore, CJ Bogusky, MJ Culberson, JC Bergman, JM Homnick, CF Zartman, CB Mosser, SD Schaber, MD Robinson, RG Koblan, KS Huber, HE Graham, SL Hartman, GD Huff, JR Williams, TM
Citation: Cj. Dinsmore et al., Conformational restriction of flexible ligands guided by the transferred NOE experiment: Potent macrocyclic inhibitors of farnesyltransferase, J AM CHEM S, 123(9), 2001, pp. 2107-2108
Antitumor efficacy of a farnesyltransferase inhibitor in transgenic mice
Authors: Gibbs, JB Graham, SL Hartman, GD Koblan, KS Kohl, NE Omer, C Pellicier, A Windle, J Oliff, A
Citation: Jb. Gibbs et al., Antitumor efficacy of a farnesyltransferase inhibitor in transgenic mice, CANC DRUG, 8, 2001, pp. 65-70
Synthesis of conformationally constrained 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine inhibitors of farnesyltransferase
Authors: Dinsmore, CJ Zartman, CB Baginsky, WF O'Neill, TJ Koblan, KS Chen, IW Mcloughlin, DA Olah, TV Huff, JR
Citation: Cj. Dinsmore et al., Synthesis of conformationally constrained 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine inhibitors of farnesyltransferase, ORG LETT, 2(22), 2000, pp. 3473-3476
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl : protein transferase inhibitor
Authors: Omer, CA Chen, ZX Diehl, RE Conner, MW Chen, HY Trumbauer, ME Gopal-Truter, S Seeburger, G Bhimnathwala, H Abrams, MT Davide, JP Ellis, MS Gibbs, JB Greenberg, I Hamilton, K Koblan, KS Kral, AM Liu, DM Lobell, RB Miller, PJ Mosser, SD O'Neill, TJ Rands, E Schaber, MD Senderak, ET Oliff, A Kohl, NE
Citation: Ca. Omer et al., Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl : protein transferase inhibitor, CANCER RES, 60(10), 2000, pp. 2680-2688
Conformation of a novel tetrapeptide inhibitor NH2-D-Trp-D-Met-Phe(pCl)-Gla-NH2 bound to farnesyl-protein transferase
Authors: Bogusky, MJ Culberson, JC Pitzenberger, SM Garsky, VM Wallace, A Pessi, A Koblan, KS
Citation: Mj. Bogusky et al., Conformation of a novel tetrapeptide inhibitor NH2-D-Trp-D-Met-Phe(pCl)-Gla-NH2 bound to farnesyl-protein transferase, J PEPT RES, 54(1), 1999, pp. 66-73
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
Authors: Dinsmore, CJ Williams, TM O'Neill, TJ Liu, DM Rands, E Culberson, JC Lobell, RB Koblan, KS Kohl, NE Gibbs, JB Oliff, AI Graham, SL Hartman, GD
Citation: Cj. Dinsmore et al., Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase, BIOORG MED, 9(23), 1999, pp. 3301-3306
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase
Authors: Ciccarone, TM MacTough, SC Williams, TM Dinsmore, CJ O'Neill, TJ Shah, D Culberson, JC Koblan, KS Kohl, NE Gibbs, JB Oliff, AI Graham, SL Hartman, GD
Citation: Tm. Ciccarone et al., Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase, BIOORG MED, 9(14), 1999, pp. 1991-1996
N-arylpiperazinone inhibitors of farnesyltransferase: Discovery and biological activity
Authors: Williams, TM Bergman, JM Brashear, K Breslin, MJ Dinsmore, CJ Hutchinson, JH MacTough, SC Stump, CA Wei, DD Zartman, CB Bogusky, MJ Culberson, JC Buser-Doepner, C Davide, J Greenberg, IB Hamilton, KA Koblan, KS Kohl, NE Liu, DM Lobell, RB Mosser, SD O'Neill, TJ Rands, E Schaber, MD Wilson, F Senderak, E Motzel, SL Gibbs, JB Graham, SL Heimbrook, DC Hartman, GD Oliff, AI Huff, JR
Citation: Tm. Williams et al., N-arylpiperazinone inhibitors of farnesyltransferase: Discovery and biological activity, J MED CHEM, 42(19), 1999, pp. 3779-3784
Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase
Authors: Anthony, NJ Gomez, RP Schaber, MD Mosser, SD Hamilton, KA O'Neil, TJ Koblan, KS Graham, SL Hartman, GD Shah, D Rands, E Kohl, NE Gibbs, JB Oliff, AI
Citation: Nj. Anthony et al., Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase, J MED CHEM, 42(17), 1999, pp. 3356-3368
Risultati: 1-18 |