Authors:
Takebayashi, Y
Goldwasser, F
Urasaki, Y
Kohlhagen, G
Pommier, Y
Citation: Y. Takebayashi et al., Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression, CLIN CANC R, 7(1), 2001, pp. 185-191
Authors:
Urasaki, Y
Laco, GS
Pourquier, P
Takebayashi, Y
Kohlhagen, G
Gioffre, C
Zhang, HL
Chatterjee, D
Pantazis, P
Pommier, Y
Citation: Y. Urasaki et al., Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line, CANCER RES, 61(5), 2001, pp. 1964-1969
Authors:
Urasaki, Y
Laco, G
Takebayashi, Y
Bailly, C
Kohlhagen, G
Pommier, Y
Citation: Y. Urasaki et al., Use of camptothecin-resistant mammalian cell lines to evaluate the role oftopoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site, CANCER RES, 61(2), 2001, pp. 504-508
Authors:
Pommier, Y
Kohlhagen, G
Pourquier, P
Sayer, JM
Kroth, H
Jerina, DM
Citation: Y. Pommier et al., Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages, P NAS US, 97(5), 2000, pp. 2040-2045
Authors:
Pourquier, P
Takebayashi, Y
Urasaki, Y
Gioffre, C
Kohlhagen, G
Pommier, Y
Citation: P. Pourquier et al., Induction of topoisomerase I cleavage complexes by 1-beta-D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells, P NAS US, 97(4), 2000, pp. 1885-1890
Authors:
Pommier, Y
Laco, GS
Kohlhagen, G
Sayer, JM
Kroth, H
Jerina, DM
Citation: Y. Pommier et al., Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]pyrene diol epoxide adducts at the 6-amino group of adenine, P NAS US, 97(20), 2000, pp. 10739-10744
Authors:
Bom, D
Curran, DP
Kruszewski, S
Zimmer, SG
Strode, JT
Kohlhagen, G
Du, W
Chavan, AJ
Fraley, KA
Bingcang, AL
Latus, LJ
Pommier, Y
Burke, TG
Citation: D. Bom et al., The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity, J MED CHEM, 43(21), 2000, pp. 3970-3980
Authors:
Cushman, M
Jayaraman, M
Vroman, JA
Fukunaga, AK
Fox, BM
Kohlhagen, G
Strumberg, D
Pommier, Y
Citation: M. Cushman et al., Synthesis of new indeno[1,2-c]isoquinolines: Cytotoxic non-camptothecin topoisomerase I inhibitors, J MED CHEM, 43(20), 2000, pp. 3688-3698
Authors:
Koo, HM
Gray-Goodrich, M
Kohlhagen, G
McWilliams, MJ
Jeffers, M
Vaigro-Wolff, A
Alvord, WG
Monks, A
Paull, KD
Pommier, Y
Vande Woude, GF
Citation: Hm. Koo et al., The ras oncogene-mediated sensitization of human cells to topoisomerase IIinhibitor-induced apoptosis, J NAT CANC, 91(3), 1999, pp. 236-244
Authors:
Takebayashi, Y
Pourquier, P
Yoshida, A
Kohlhagen, G
Pommier, Y
Citation: Y. Takebayashi et al., Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancerdrug that selectively alkylates DNA in the minor groove, P NAS US, 96(13), 1999, pp. 7196-7201
Authors:
Nieves-Neira, W
Rivera, MI
Kohlhagen, G
Hursey, ML
Pourquier, P
Sausville, EA
Pommier, Y
Citation: W. Nieves-neira et al., DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells, MOLEC PHARM, 56(3), 1999, pp. 478-484
Authors:
Brangi, M
Litman, T
Ciotti, M
Nishiyama, K
Kohlhagen, G
Takimoto, C
Robey, R
Pommier, Y
Fojo, T
Bates, SE
Citation: M. Brangi et al., Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation inMXR-expressing cells, CANCER RES, 59(23), 1999, pp. 5938-5946