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Results: 1-16 |
Results: 16
Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression
Authors: Takebayashi, Y Goldwasser, F Urasaki, Y Kohlhagen, G Pommier, Y
Citation: Y. Takebayashi et al., Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression, CLIN CANC R, 7(1), 2001, pp. 185-191
Human mitochondrial topoisomerase I
Authors: Zhang, HL Barcelo, JM Lee, B Kohlhagen, G Zimonjic, DB Popescu, NC Pommier, Y
Citation: Hl. Zhang et al., Human mitochondrial topoisomerase I, P NAS US, 98(19), 2001, pp. 10608-10613
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line
Authors: Urasaki, Y Laco, GS Pourquier, P Takebayashi, Y Kohlhagen, G Gioffre, C Zhang, HL Chatterjee, D Pantazis, P Pommier, Y
Citation: Y. Urasaki et al., Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line, CANCER RES, 61(5), 2001, pp. 1964-1969
Use of camptothecin-resistant mammalian cell lines to evaluate the role oftopoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site
Authors: Urasaki, Y Laco, G Takebayashi, Y Bailly, C Kohlhagen, G Pommier, Y
Citation: Y. Urasaki et al., Use of camptothecin-resistant mammalian cell lines to evaluate the role oftopoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site, CANCER RES, 61(2), 2001, pp. 504-508
Bay-region diol epoxides of benzo[a]pyrene are stealth poisons of topoisomerase I
Authors: Jerina, DM Sayer, JM Kroth, H Kohlhagen, G Laco, GS Pommier, Y
Citation: Dm. Jerina et al., Bay-region diol epoxides of benzo[a]pyrene are stealth poisons of topoisomerase I, POLYCYCL AR, 21(1-4), 2000, pp. 53-62
Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages
Authors: Pommier, Y Kohlhagen, G Pourquier, P Sayer, JM Kroth, H Jerina, DM
Citation: Y. Pommier et al., Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages, P NAS US, 97(5), 2000, pp. 2040-2045
Induction of topoisomerase I cleavage complexes by 1-beta-D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells
Authors: Pourquier, P Takebayashi, Y Urasaki, Y Gioffre, C Kohlhagen, G Pommier, Y
Citation: P. Pourquier et al., Induction of topoisomerase I cleavage complexes by 1-beta-D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells, P NAS US, 97(4), 2000, pp. 1885-1890
Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]pyrene diol epoxide adducts at the 6-amino group of adenine
Authors: Pommier, Y Laco, GS Kohlhagen, G Sayer, JM Kroth, H Jerina, DM
Citation: Y. Pommier et al., Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]pyrene diol epoxide adducts at the 6-amino group of adenine, P NAS US, 97(20), 2000, pp. 10739-10744
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity
Authors: Bom, D Curran, DP Kruszewski, S Zimmer, SG Strode, JT Kohlhagen, G Du, W Chavan, AJ Fraley, KA Bingcang, AL Latus, LJ Pommier, Y Burke, TG
Citation: D. Bom et al., The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity, J MED CHEM, 43(21), 2000, pp. 3970-3980
Synthesis of new indeno[1,2-c]isoquinolines: Cytotoxic non-camptothecin topoisomerase I inhibitors
Authors: Cushman, M Jayaraman, M Vroman, JA Fukunaga, AK Fox, BM Kohlhagen, G Strumberg, D Pommier, Y
Citation: M. Cushman et al., Synthesis of new indeno[1,2-c]isoquinolines: Cytotoxic non-camptothecin topoisomerase I inhibitors, J MED CHEM, 43(20), 2000, pp. 3688-3698
The ras oncogene-mediated sensitization of human cells to topoisomerase IIinhibitor-induced apoptosis
Authors: Koo, HM Gray-Goodrich, M Kohlhagen, G McWilliams, MJ Jeffers, M Vaigro-Wolff, A Alvord, WG Monks, A Paull, KD Pommier, Y Vande Woude, GF
Citation: Hm. Koo et al., The ras oncogene-mediated sensitization of human cells to topoisomerase IIinhibitor-induced apoptosis, J NAT CANC, 91(3), 1999, pp. 236-244
Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancerdrug that selectively alkylates DNA in the minor groove
Authors: Takebayashi, Y Pourquier, P Yoshida, A Kohlhagen, G Pommier, Y
Citation: Y. Takebayashi et al., Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancerdrug that selectively alkylates DNA in the minor groove, P NAS US, 96(13), 1999, pp. 7196-7201
DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells
Authors: Nieves-Neira, W Rivera, MI Kohlhagen, G Hursey, ML Pourquier, P Sausville, EA Pommier, Y
Citation: W. Nieves-neira et al., DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells, MOLEC PHARM, 56(3), 1999, pp. 478-484
Topoisomerase poisoning activity of novel disaccharide anthracyclines
Authors: Guano, F Pourquier, P Tinelli, S Binaschi, M Bigioni, M Animati, F Manzini, S Zunino, F Kohlhagen, G Pommier, Y Capranico, G
Citation: F. Guano et al., Topoisomerase poisoning activity of novel disaccharide anthracyclines, MOLEC PHARM, 56(1), 1999, pp. 77-84
Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation inMXR-expressing cells
Authors: Brangi, M Litman, T Ciotti, M Nishiyama, K Kohlhagen, G Takimoto, C Robey, R Pommier, Y Fojo, T Bates, SE
Citation: M. Brangi et al., Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation inMXR-expressing cells, CANCER RES, 59(23), 1999, pp. 5938-5946
Topoisomerase I and II activity assays
Authors: Pourquier, P Kohlhagen, G Ueng, LM Pommier, Y
Citation: P. Pourquier et al., Topoisomerase I and II activity assays, METH MOL M, 28, 1999, pp. 95-110
Risultati: 1-16 |