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Results: 1-24 |
Results: 24
Pyridopyrimidine analogues as novel adenosine kinase inhibitors
Authors: Zheng, GZ Lee, CH Pratt, JK Perner, RJ Jiang, MQ Gomtsyan, A Matulenko, MA Mao, Y Koenig, JR Kim, KH Muchmore, S Yu, HX Kohlhaas, K Alexander, KM McGaraughty, S Chu, KL Wismer, CT Mikusa, J Jarvis, MF Marsh, K Kowaluk, EA Bhagwat, SS Stewart, AO
Citation: Gz. Zheng et al., Pyridopyrimidine analogues as novel adenosine kinase inhibitors, BIOORG MED, 11(16), 2001, pp. 2071-2074
Structure-activity studies of 5-substituted pyridopyrimidines as adenosinekinase inhibitors
Authors: Cowart, M Lee, CH Gfesser, GA Bayburt, EK Bhagwat, SS Stewart, AO Yu, HX Kohlhaas, KL McGaraughty, S Wismer, CT Mikusa, J Zhu, C Alexander, KM Jarvis, MF Kowaluk, EA
Citation: M. Cowart et al., Structure-activity studies of 5-substituted pyridopyrimidines as adenosinekinase inhibitors, BIOORG MED, 11(1), 2001, pp. 83-86
Pharmacological characterization of P2X(3) homomeric and heteromeric channels in nociceptive signaling and behavior
Authors: Jarvis, MF Kowaluk, EA
Citation: Mf. Jarvis et Ea. Kowaluk, Pharmacological characterization of P2X(3) homomeric and heteromeric channels in nociceptive signaling and behavior, DRUG DEV R, 52(1-2), 2001, pp. 220-231
Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis
Authors: Boyle, DL Kowaluk, EA Jarvis, MF Lee, CH Bhagwat, SS Williams, M Firestein, GS
Citation: Dl. Boyle et al., Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis, J PHARM EXP, 296(2), 2001, pp. 495-500
Effects of a-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: Evaluation of the sites of action
Authors: McGaraughty, S Chu, KL Wismer, CT Mikusa, J Zhu, CZ Cowart, M Kowaluk, EA Jarvis, MF
Citation: S. Mcgaraughty et al., Effects of a-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: Evaluation of the sites of action, J PHARM EXP, 296(2), 2001, pp. 501-509
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor
Authors: Lee, CH Jiang, MQ Cowart, M Gfesser, G Perner, R Kim, KH Gu, YG Williams, M Jarvis, MF Kowaluk, EA Stewart, AO Bhagwat, SS
Citation: Ch. Lee et al., Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor, J MED CHEM, 44(13), 2001, pp. 2133-2138
The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury
Authors: Suzuki, R Stanfa, LC Kowaluk, EA Williams, M Jarvis, MF Dickenson, AH
Citation: R. Suzuki et al., The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury, BR J PHARM, 132(7), 2001, pp. 1615-1623
Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue
Authors: Jarvis, MF Wismer, CT Schweitzer, E Yu, HX van Biesen, T Lynch, KJ Burgard, EC Kowaluk, EA
Citation: Mf. Jarvis et al., Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue, BR J PHARM, 132(1), 2001, pp. 259-269
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats
Authors: Zhu, CZ Mikusa, J Chu, KL Cowart, M Kowaluk, EA Jarvis, MF McGaraughty, S
Citation: Cz. Zhu et al., A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats, BRAIN RES, 905(1-2), 2001, pp. 104-110
Therapeutic potential of adenosine kinase inhibitors
Authors: Kowaluk, EA Jarvis, MF
Citation: Ea. Kowaluk et Mf. Jarvis, Therapeutic potential of adenosine kinase inhibitors, EXPERT OP I, 9(3), 2000, pp. 551-564
Recent advances in development of novel analgesics
Authors: Kowaluk, EA Lynch, KJ Jarvis, MF
Citation: Ea. Kowaluk et al., Recent advances in development of novel analgesics, ANNU REP M, 35, 2000, pp. 21-30
Competitive antagonism of recombinant P2X(2/3) receptors by 2 ',3 '-O-(2,4,6-trinitrophenyl) adenosine 5 '-triphosphate (TNP-ATP)
Authors: Burgard, EC Niforatos, W Van Biesen, T Lynch, KJ Kage, KL Touma, E Kowaluk, EA Jarvis, MF
Citation: Ec. Burgard et al., Competitive antagonism of recombinant P2X(2/3) receptors by 2 ',3 '-O-(2,4,6-trinitrophenyl) adenosine 5 '-triphosphate (TNP-ATP), MOLEC PHARM, 58(6), 2000, pp. 1502-1510
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse
Authors: Jarvis, MF Yu, HX Kohlhaas, K Alexander, K Lee, CH Jiang, MQ Bhagwat, SS Williams, M Kowaluk, EA
Citation: Mf. Jarvis et al., ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse, J PHARM EXP, 295(3), 2000, pp. 1156-1164
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat
Authors: Kowaluk, EA Mikusa, J Wismer, CT Zhu, CZ Schweitzer, E Lynch, JJ Lee, CH Jiang, MQ Bhagwat, SS Gomtsyan, A McKie, J Cox, BF Polakowski, J Reinhart, G Williams, M Jarvis, MF
Citation: Ea. Kowaluk et al., ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat, J PHARM EXP, 295(3), 2000, pp. 1165-1174
Design of adenosine kinase inhibitors from the NMR-based screening of fragments
Authors: Hajduk, PJ Gomtsyan, A Didomenico, S Cowart, M Bayburt, EK Solomon, L Severin, J Smith, R Walter, K Holzman, TF Stewart, A McGaraughty, S Jarvis, MF Kowaluk, EA Fesik, SW
Citation: Pj. Hajduk et al., Design of adenosine kinase inhibitors from the NMR-based screening of fragments, J MED CHEM, 43(25), 2000, pp. 4781-4786
ABT-627, an endothelin ETA receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain
Authors: Jarvis, MF Wessale, JL Zhu, CZ Lynch, JJ Dayton, BD Calzadilla, SV Padley, RJ Opgenorth, TJ Kowaluk, EA
Citation: Mf. Jarvis et al., ABT-627, an endothelin ETA receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain, EUR J PHARM, 388(1), 2000, pp. 29-35
Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats
Authors: Britton, DR Mikusa, J Lee, CH Jarvis, MF Williams, M Kowaluk, EA
Citation: Dr. Britton et al., Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats, NEUROSCI L, 266(2), 1999, pp. 93-96
Lack of specificity of [S-35]-ATP gamma S and [S-35]-ADP beta S as radioligands for ionotropic and metabotropic P2 receptor binding
Authors: Yu, HX Bianchi, B Metzger, R Lynch, KJ Kowaluk, EA Jawis, MF van Biesen, T
Citation: Hx. Yu et al., Lack of specificity of [S-35]-ATP gamma S and [S-35]-ADP beta S as radioligands for ionotropic and metabotropic P2 receptor binding, DRUG DEV R, 48(2), 1999, pp. 84-93
Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice
Authors: Kowaluk, EA Kohlhaas, KL Bannon, A Gunther, K Lynch, JJ Jarvis, MF
Citation: Ea. Kowaluk et al., Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice, PHARM BIO B, 63(1), 1999, pp. 83-91
Molecular and functional characterization of human P2X(2) receptors
Authors: Lynch, KJ Touma, E Niforatos, W Kage, KL Burgard, EC Van Biesen, T Kowaluk, EA Jarvis, MF
Citation: Kj. Lynch et al., Molecular and functional characterization of human P2X(2) receptors, MOLEC PHARM, 56(6), 1999, pp. 1171-1181
Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue
Authors: Alexander, K Niforatos, W Bianchi, B Burgard, EC Lynch, KJ Kowaluk, EA Jarvis, MF van Biesen, T
Citation: K. Alexander et al., Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue, J PHARM EXP, 291(3), 1999, pp. 1135-1142
P2X receptor-mediated ionic currents in dorsal root ganglion neurons
Authors: Burgard, EC Niforatos, W Van Biesen, T Lynch, KJ Touma, E Metzger, RE Kowaluk, EA Jarvis, MF
Citation: Ec. Burgard et al., P2X receptor-mediated ionic currents in dorsal root ganglion neurons, J NEUROPHYS, 82(3), 1999, pp. 1590-1598
Emerging molecular approaches to pain therapy
Authors: Williams, M Kowaluk, EA Arneric, SP
Citation: M. Williams et al., Emerging molecular approaches to pain therapy, J MED CHEM, 42(9), 1999, pp. 1481-1500
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain
Authors: Lynch, JL Jarvis, MF Kowaluk, EA
Citation: Jl. Lynch et al., An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain, EUR J PHARM, 364(2-3), 1999, pp. 141-146
Risultati: 1-24 |