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Results: 1-25 | 26-35
Results: 1-25/35
Antibody response to DT-GM, a novel fusion toxin consisting of a truncateddiphtheria toxin (DT) linked to human granulocyte-macrophage colony stimulating factor (GM), during a phase I trial of patients with relapsed or refractory acute myeloid leukemia
Authors: Hall, PD Virella, G Willoughby, T Atchley, DH Kreitman, RJ Frankel, AE
Citation: Pd. Hall et al., Antibody response to DT-GM, a novel fusion toxin consisting of a truncateddiphtheria toxin (DT) linked to human granulocyte-macrophage colony stimulating factor (GM), during a phase I trial of patients with relapsed or refractory acute myeloid leukemia, CLIN IMMUNO, 100(2), 2001, pp. 191-197
Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia
Authors: Kreitman, RJ Wilson, WH Bergeron, K Raggio, M Stetler-Stevenson, M FitzGerald, DJ Pastan, I
Citation: Rj. Kreitman et al., Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia, N ENG J MED, 345(4), 2001, pp. 241-247
Treatment of hairy-cell leukemia - Reply
Authors: Kreitman, RJ Wilson, WH Pastan, I
Citation: Rj. Kreitman et al., Treatment of hairy-cell leukemia - Reply, N ENG J MED, 345(20), 2001, pp. 1500-1501
Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin
Authors: Rozemuller, H Chowdhury, PS Pastan, I Kreitman, RJ
Citation: H. Rozemuller et al., Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin, INT J CANC, 92(6), 2001, pp. 861-870
Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity
Authors: Onda, M Nagata, S Tsutsumi, Y Vincent, JJ Wang, QC Kreitman, RJ Lee, B Pastan, I
Citation: M. Onda et al., Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity, CANCER RES, 61(13), 2001, pp. 5070-5077
Quantification of immunotoxin number for complete therapeutic response
Authors: Kreitman, RJ
Citation: Rj. Kreitman, Quantification of immunotoxin number for complete therapeutic response, METH MOL B, 166, 2001, pp. 111-123
Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin,a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma
Authors: Hassan, R Viner, JL Wang, QC Margulies, I Kreitman, RJ Pastan, I
Citation: R. Hassan et al., Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin,a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma, J IMMUNOTH, 23(4), 2000, pp. 473-479
Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma
Authors: Rand, RW Kreitman, RJ Patronas, N Varricchio, F Pastan, I Puri, RK
Citation: Rw. Rand et al., Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma, CLIN CANC R, 6(6), 2000, pp. 2157-2165
Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias
Authors: Kreitman, RJ Margulies, I Stetler-Stevenson, M Wang, QC FitzGerald, DJP Pastan, I
Citation: Rj. Kreitman et al., Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias, CLIN CANC R, 6(4), 2000, pp. 1476-1487
Targeted toxins
Authors: Frankel, AE Kreitman, RJ Sausville, EA
Citation: Ae. Frankel et al., Targeted toxins, CLIN CANC R, 6(2), 2000, pp. 326-334
Hairy cell leukemia, a B-cell neoplasm that is particularly sensitive to the cytotoxic effect of anti-Tac(Fv)-PE38 (LMB-2)
Authors: Robbins, DH Marguiles, I Stetler-Stevenson, M Kreitman, RJ
Citation: Dh. Robbins et al., Hairy cell leukemia, a B-cell neoplasm that is particularly sensitive to the cytotoxic effect of anti-Tac(Fv)-PE38 (LMB-2), CLIN CANC R, 6(2), 2000, pp. 693-700
Human breast carcinoma cells express type IIIL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo
Authors: Leland, P Taguchi, J Husain, SR Kreitman, RJ Pastan, I Puri, RK
Citation: P. Leland et al., Human breast carcinoma cells express type IIIL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo, MOL MED, 6(3), 2000, pp. 165-178
Development of lymphoproliferative disorder of granular lymphocytes in association with hairy cell leukemia
Authors: Xie, XY Sorbara, L Kreitman, RJ Fukushima, PI Kingma, DW Stetler-Stevenson, M
Citation: Xy. Xie et al., Development of lymphoproliferative disorder of granular lymphocytes in association with hairy cell leukemia, LEUK LYMPH, 37(1-2), 2000, pp. 97-104
Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias
Authors: Frankel, AE McCubrey, JA Miller, MS Delatte, S Ramage, J Kiser, M Kucera, GL Alexander, RL Beran, M Tagge, EP Kreitman, RJ Hogge, DE
Citation: Ae. Frankel et al., Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias, LEUKEMIA, 14(4), 2000, pp. 576-585
Phase I trial of recombinant immunotoxin anti-Tac(Fv)PE38 (LMB-2) in patients with hematologic malignancies
Authors: Kreitman, RJ Wilson, WH White, JD Stetler-Stevenson, M Jaffe, ES Giardina, S Waldmann, TA Pastan, I
Citation: Rj. Kreitman et al., Phase I trial of recombinant immunotoxin anti-Tac(Fv)PE38 (LMB-2) in patients with hematologic malignancies, J CL ONCOL, 18(8), 2000, pp. 1622-1636
Pharmacokinetics of In-111- and I-125-labeled antiTac single-chain Fv recombinant immunotoxin
Authors: Kobayashi, H Kao, CHK Kreitman, RJ Le, N Kim, MK Brechbiel, MW Paik, CH Pastan, I Carrasquillo, JA
Citation: H. Kobayashi et al., Pharmacokinetics of In-111- and I-125-labeled antiTac single-chain Fv recombinant immunotoxin, J NUCL MED, 41(4), 2000, pp. 755-762
Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function
Authors: Kaneko, S Hikida, T Watanabe, D Ichinose, H Nagatsu, T Kreitman, RJ Pastan, I Nakanishi, S
Citation: S. Kaneko et al., Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function, SCIENCE, 289(5479), 2000, pp. 633-637
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
Authors: Tsutsumi, Y Onda, M Nagata, S Lee, B Kreitman, RJ Pastan, I
Citation: Y. Tsutsumi et al., Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity, P NAS US, 97(15), 2000, pp. 8548-8553
Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2
Authors: Onda, M Willingham, M Wang, QC Kreitman, RJ Tsutsumi, Y Nagata, S Pastan, I
Citation: M. Onda et al., Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2, J IMMUNOL, 165(12), 2000, pp. 7150-7156
Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor
Authors: Rajagopal, V Kreitman, RJ
Citation: V. Rajagopal et Rj. Kreitman, Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor, J BIOL CHEM, 275(11), 2000, pp. 7566-7573
Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies
Authors: Keppler-Hafkemeyer, A Kreitman, RJ Pastan, I
Citation: A. Keppler-hafkemeyer et al., Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies, INT J CANC, 87(1), 2000, pp. 86-94
Making fusion toxins to target leukemia and lymphoma
Authors: Kreitman, RJ Pastan, I
Citation: Rj. Kreitman et I. Pastan, Making fusion toxins to target leukemia and lymphoma, METH MOL M, 25, 2000, pp. 215-226
Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft- model
Authors: Husain, SR Kreitman, RJ Pastan, I Puri, RK
Citation: Sr. Husain et al., Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft- model, NAT MED, 5(7), 1999, pp. 817-822
Immunotoxins in cancer therapy
Authors: Kreitman, RJ
Citation: Rj. Kreitman, Immunotoxins in cancer therapy, CURR OP IM, 11(5), 1999, pp. 570-578
DT388-GM-CSF, a novel fusion toxin consisting of a truncated diphtheria toxin fused to human granulocyte-macrophage colony-stimulating factor, prolongs host survival in a SCID mouse model of acute myeloid leukemia
Authors: Hall, PD Willingham, MC Kreitman, RJ Frankel, AE
Citation: Pd. Hall et al., DT388-GM-CSF, a novel fusion toxin consisting of a truncated diphtheria toxin fused to human granulocyte-macrophage colony-stimulating factor, prolongs host survival in a SCID mouse model of acute myeloid leukemia, LEUKEMIA, 13(4), 1999, pp. 629-633
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