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Results: 1-25 | 26-28
Results: 1-25/28
L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR
Authors: SANDERSON PEJ CUTRONA KJ DORSEY BD DYER DL MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ GARDELL SJ KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 817-822
IDENTIFICATION AND SAR FOR A SELECTIVE, NONPEPTIDYL THROMBIN INHIBITOR
Authors: NAYLOROLSEN AM PONTICELLO GS LEWIS SD MULICHAK AM CHEN ZG HABECKER CN PHILLIPS BT SANDERS WM TUCKER TJ SHAFER JA VACCA JP
Citation: Am. Naylorolsen et al., IDENTIFICATION AND SAR FOR A SELECTIVE, NONPEPTIDYL THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1697-1702
C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION
Authors: ISAACS RCA CUTRONA KJ NEWTON CL SANDERSON PEJ SOLINSKY MG BASKIN EP CHEN IW COOPER CM COOK JJ GARDELL SJ LEWIS SD LUCAS RJ LYLE EA LYNCH JJ NAYLOROLSEN AM STRANIERI MT VASTAG K VACCA JP
Citation: Rca. Isaacs et al., C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1719-1724
ASSESSMENT OF THROMBIN INHIBITOR EFFICACY IN A NOVEL RABBIT MODEL OF SIMULTANEOUS ARTERIAL AND VENOUS THROMBOSIS
Authors: LYLE EM LEWIS SD LEHMAN ED GARDELL SJ MOTZEL SL LYNCH JJ
Citation: Em. Lyle et al., ASSESSMENT OF THROMBIN INHIBITOR EFFICACY IN A NOVEL RABBIT MODEL OF SIMULTANEOUS ARTERIAL AND VENOUS THROMBOSIS, Thrombosis and haemostasis, 79(3), 1998, pp. 656-662
DESIGN, SYNTHESES, AND ACTIVITY OF NEW 3-[(SULFONYLARYL)-AMINO]-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES AS ALPHA-THROMBIN INHIBITORS
Authors: DUMAS D LECLERC G BALDWIN JJ LEWIS SD MURCKO M NAYLOROLSEN AM
Citation: D. Dumas et al., DESIGN, SYNTHESES, AND ACTIVITY OF NEW 3-[(SULFONYLARYL)-AMINO]-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES AS ALPHA-THROMBIN INHIBITORS, European journal of medicinal chemistry, 33(6), 1998, pp. 471-488
DESIGN OF NOVEL, POTENT, NONCOVALENT INHIBITORS OF THROMBIN WITH NONBASIC P-1 SUBSTRUCTURES - RAPID STRUCTURE-ACTIVITY STUDIES BY SOLID-PHASE SYNTHESIS
Authors: LUMMA WC WITHERUP KM TUCKER TJ BRADY SF SISKO JT NAYLOROLSEN AM LEWIS SD LUCAS BJ VACCA JP
Citation: Wc. Lumma et al., DESIGN OF NOVEL, POTENT, NONCOVALENT INHIBITORS OF THROMBIN WITH NONBASIC P-1 SUBSTRUCTURES - RAPID STRUCTURE-ACTIVITY STUDIES BY SOLID-PHASE SYNTHESIS, Journal of medicinal chemistry, 41(7), 1998, pp. 1011-1013
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES
Authors: SANDERSON PEJ LYLE TA CUTRONA KJ DYER DL DORSEY BD MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ COOPER CM GARDELL SJ HARE TR KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K YAN YW SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES, Journal of medicinal chemistry, 41(23), 1998, pp. 4466-4474
DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION
Authors: TUCKER TJ BRADY SF LUMMA WC LEWIS SD GARDELL SJ NAYLOROLSEN AM YAN YW SISKO JT STAUFFER KJ LUCAS BJ LYNCH JJ COOK JJ STRANIERI MT HOLAHAN MA LYLE EA BASKIN EP CHEN IW DANCHECK KB KRUEGER JA COOPER CM VACCA JP
Citation: Tj. Tucker et al., DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION, Journal of medicinal chemistry, 41(17), 1998, pp. 3210-3219
CHARACTERIZATION OF THE 2-STEP PATHWAY FOR INHIBITION OF THROMBIN BY ALPHA-KETOAMIDE TRANSITION-STATE ANALOGS
Authors: LEWIS SD LUCAS BJ BRADY SF SISKO JT CUTRONA KJ SANDERSON PEJ FREIDINGER RM MAO SS GARDELL SJ SHAFER JA
Citation: Sd. Lewis et al., CHARACTERIZATION OF THE 2-STEP PATHWAY FOR INHIBITION OF THROMBIN BY ALPHA-KETOAMIDE TRANSITION-STATE ANALOGS, The Journal of biological chemistry, 273(9), 1998, pp. 4843-4854
SELECTIVE-INHIBITION OF FACTOR XA IN THE PROTHROMBINASE COMPLEX BY THE CARBOXYL-TERMINAL DOMAIN OF ANTISTASIN
Authors: MAO SS PRZYSIECKI CT KRUEGER JA COOPER CM LEWIS SD JOYCE J LELLIS C GARSKY VM SARDANA M SHAFER JA
Citation: Ss. Mao et al., SELECTIVE-INHIBITION OF FACTOR XA IN THE PROTHROMBINASE COMPLEX BY THE CARBOXYL-TERMINAL DOMAIN OF ANTISTASIN, The Journal of biological chemistry, 273(46), 1998, pp. 30086-30091
L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR
Authors: SANDERSON PEJ DYER DL NAYLOROLSEN AM VACCA JP GARDELL SJ LEWIS SD LUCAS BJ LYLE EA LYNCH JJ MULICHAK AM
Citation: Pej. Sanderson et al., L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1497-1500
SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR
Authors: LYLE TA CHEN ZG APPLEBY SD FREIDINGER RM GARDELL SJ LEWIS SD LI Y LYLE EA LYNCH JJ MULICHAK AM NG AS NAYLOROLSEN AM SANDERS WM
Citation: Ta. Lyle et al., SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 67-72
DESIGN OF HIGHLY POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE A NOVEL LIPOPHILIC BINDING POCKET IN THE THROMBIN ACTIVE-SITE
Authors: TUCKER TJ LUMMA WC MULICHAK AM CHEN ZG NAYLOROLSEN AM LEWIS SD LUCAS R FREIDINGER RM KUO LC
Citation: Tj. Tucker et al., DESIGN OF HIGHLY POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE A NOVEL LIPOPHILIC BINDING POCKET IN THE THROMBIN ACTIVE-SITE, Journal of medicinal chemistry, 40(6), 1997, pp. 830-832
DISCOVERY OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS INCORPORATING AMINOPYRIDYL MOIETIES AT THE P1 POSITION
Authors: FENG DM GARDELL SJ LEWIS SD BOCK MG CHEN ZG FREIDINGER RM NAYLOROLSEN AM RAMJIT HG WOLTMANN R BASKIN EP LYNCH JJ LUCAS R SHAFER JA DANCHECK KB CHEN IW MAO SS KRUEGER JA HARE TR MULICHAK AM VACCA JP
Citation: Dm. Feng et al., DISCOVERY OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS INCORPORATING AMINOPYRIDYL MOIETIES AT THE P1 POSITION, Journal of medicinal chemistry, 40(23), 1997, pp. 3726-3733
SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ SISKO JT LYNCH JJ LYLE EA BASKIN EP WOLTMANN RF APPLEBY SD
Citation: Tj. Tucker et al., SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION, Journal of medicinal chemistry, 40(22), 1997, pp. 3687-3693
POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ BASKIN EP WOLTMANN R LYNCH JJ LYLE EA APPLEBY SD CHEN IW DANCHECK KB VACCA JP
Citation: Tj. Tucker et al., POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY, Journal of medicinal chemistry, 40(11), 1997, pp. 1565-1569
SIMULTANEOUS ASSESSMENT OF ARTERIAL AND VENOUS THROMBIN INHIBITOR EFFICACY IN A RABBIT MODEL OF FECL3-INDUCED THROMBOSIS
Authors: LYLE EM BRADY SF LEWIS SD NUTT RF LYNCH JJ
Citation: Em. Lyle et al., SIMULTANEOUS ASSESSMENT OF ARTERIAL AND VENOUS THROMBIN INHIBITOR EFFICACY IN A RABBIT MODEL OF FECL3-INDUCED THROMBOSIS, The FASEB journal, 10(3), 1996, pp. 2502-2502
INITIAL REPORT OF ROTATIONAL ABLATION - THE TORONTO HOSPITAL EXPERIENCE
Authors: KIMBALL BP LEWIS SD ALMOND DG SCHWARTZ L
Citation: Bp. Kimball et al., INITIAL REPORT OF ROTATIONAL ABLATION - THE TORONTO HOSPITAL EXPERIENCE, Canadian journal of cardiology, 12(2), 1996, pp. 145-150
THE EXON ENCODING THE FIBRONECTIN TYPE III-9 REPEAT IS CONSTITUTIVELYINCLUDED IN THE MESSENGER-RNA FROM CHICK LIMB MESENCHYME AND CARTILAGE
Authors: GEHRIS AL BRANDLI DW LEWIS SD BENNETT VD
Citation: Al. Gehris et al., THE EXON ENCODING THE FIBRONECTIN TYPE III-9 REPEAT IS CONSTITUTIVELYINCLUDED IN THE MESSENGER-RNA FROM CHICK LIMB MESENCHYME AND CARTILAGE, Biochimica et biophysica acta. Molecular cell research, 1311(1), 1996, pp. 5-12
SPLICING PATTERNS OF FIBRONECTIN MESSENGER-RNA FROM NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR-CARTILAGE
Authors: RENCIC A GEHRIS AL LEWIS SD HUME EL BENNETT VD
Citation: A. Rencic et al., SPLICING PATTERNS OF FIBRONECTIN MESSENGER-RNA FROM NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR-CARTILAGE, Osteoarthritis and cartilage, 3(3), 1995, pp. 187-196
INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES
Authors: LEWIS SD NG AS LYLE EA MELLOTT MJ APPLEBY SD BRADY SF STAUFFER KJ SISKO JT MAO SS VEBER DF NUTT RF LYNCH JJ COOK JJ GARDELL SJ SHAFER JA
Citation: Sd. Lewis et al., INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES, Thrombosis and haemostasis, 74(4), 1995, pp. 1107-1112
CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROM RESOLUTION
Authors: CHEN ZG LI Y MULICHAK AM LEWIS SD SHAFER JA
Citation: Zg. Chen et al., CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROM RESOLUTION, Archives of biochemistry and biophysics, 322(1), 1995, pp. 198-203
IDENTIFICATION OF BASIC-AMINO-ACID RESIDUES IN THROMBIN ESSENTIAL FORHEPARIN-CATALYZED INACTIVATION BY ANTITHROMBIN-III
Authors: GAN ZR LI YP CHEN ZG LEWIS SD SHAFER JA
Citation: Zr. Gan et al., IDENTIFICATION OF BASIC-AMINO-ACID RESIDUES IN THROMBIN ESSENTIAL FORHEPARIN-CATALYZED INACTIVATION BY ANTITHROMBIN-III, The Journal of biological chemistry, 269(2), 1994, pp. 1301-1305
TECTONICS AND GEOLOGY OF SPREADING RIDGE SUBDUCTION AT THE CHILE TRIPLE JUNCTION - A SYNTHESIS OF RESULTS FROM LEG-141 OF THE OCEAN DRILLING PROGRAM
Authors: BEHRMANN JH LEWIS SD CANDE SC MUSGRAVE R BANGS N BODEN P BROWN K COLLOMBAT H DIDENKO AN DIDYK BM FROELICH PN GOLOVCHENKO X FORSYTHE R KURNOSOV V LINDSLEYGRIFFIN N MARSAGLIA K OSOZAWA S PRIOR D SAWYER D SCHOLL D SPIEGLER D STRAND K TAKAHASHI K TORRES M VEGAFAUNDEZ M VERGARA H WASADA A
Citation: Jh. Behrmann et al., TECTONICS AND GEOLOGY OF SPREADING RIDGE SUBDUCTION AT THE CHILE TRIPLE JUNCTION - A SYNTHESIS OF RESULTS FROM LEG-141 OF THE OCEAN DRILLING PROGRAM, Geologische Rundschau, 83(4), 1994, pp. 832-852
Risultati: 1-25 | 26-28