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Results: 1-10 |
Results: 10
DESIGN OF NOVEL, POTENT, NONCOVALENT INHIBITORS OF THROMBIN WITH NONBASIC P-1 SUBSTRUCTURES - RAPID STRUCTURE-ACTIVITY STUDIES BY SOLID-PHASE SYNTHESIS
Authors: LUMMA WC WITHERUP KM TUCKER TJ BRADY SF SISKO JT NAYLOROLSEN AM LEWIS SD LUCAS BJ VACCA JP
Citation: Wc. Lumma et al., DESIGN OF NOVEL, POTENT, NONCOVALENT INHIBITORS OF THROMBIN WITH NONBASIC P-1 SUBSTRUCTURES - RAPID STRUCTURE-ACTIVITY STUDIES BY SOLID-PHASE SYNTHESIS, Journal of medicinal chemistry, 41(7), 1998, pp. 1011-1013
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION
Authors: TUCKER TJ BRADY SF LUMMA WC LEWIS SD GARDELL SJ NAYLOROLSEN AM YAN YW SISKO JT STAUFFER KJ LUCAS BJ LYNCH JJ COOK JJ STRANIERI MT HOLAHAN MA LYLE EA BASKIN EP CHEN IW DANCHECK KB KRUEGER JA COOPER CM VACCA JP
Citation: Tj. Tucker et al., DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION, Journal of medicinal chemistry, 41(17), 1998, pp. 3210-3219
DESIGN OF HIGHLY POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE A NOVEL LIPOPHILIC BINDING POCKET IN THE THROMBIN ACTIVE-SITE
Authors: TUCKER TJ LUMMA WC MULICHAK AM CHEN ZG NAYLOROLSEN AM LEWIS SD LUCAS R FREIDINGER RM KUO LC
Citation: Tj. Tucker et al., DESIGN OF HIGHLY POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE A NOVEL LIPOPHILIC BINDING POCKET IN THE THROMBIN ACTIVE-SITE, Journal of medicinal chemistry, 40(6), 1997, pp. 830-832
SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ SISKO JT LYNCH JJ LYLE EA BASKIN EP WOLTMANN RF APPLEBY SD
Citation: Tj. Tucker et al., SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION, Journal of medicinal chemistry, 40(22), 1997, pp. 3687-3693
POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ BASKIN EP WOLTMANN R LYNCH JJ LYLE EA APPLEBY SD CHEN IW DANCHECK KB VACCA JP
Citation: Tj. Tucker et al., POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY, Journal of medicinal chemistry, 40(11), 1997, pp. 1565-1569
2-HETEROCYCLIC INDOLE-3-SULFONES AS INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE
Authors: YOUNG SD AMBLARD MC BRITCHER SF GREY VE TRAN LO LUMMA WC HUFF JR SCHLEIF WA EMINI EE OBRIEN JA PETTIBONE DJ
Citation: Sd. Young et al., 2-HETEROCYCLIC INDOLE-3-SULFONES AS INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE, Bioorganic & medicinal chemistry letters, 5(5), 1995, pp. 491-496
L-743,726 (DMP-266) - A NOVEL, HIGHLY POTENT NONNUCLEOSIDE INHIBITOR OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE
Authors: YOUNG SD BRITCHER SF TRAN LO PAYNE LS LUMMA WC LYLE TA HUFF JR ANDERSON PS OLSEN DB CARROLL SS PETTIBONE DJ OBRIEN JA BALL RG BALANI SK LIN JH CHEN IW SCHLEIF WA SARDANA VV LONG WJ BYRNES VW EMINI EA
Citation: Sd. Young et al., L-743,726 (DMP-266) - A NOVEL, HIGHLY POTENT NONNUCLEOSIDE INHIBITOR OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, Antimicrobial agents and chemotherapy, 39(12), 1995, pp. 2602-2605
MARTINELLINE AND MARTINELLIC ACID, NOVEL G-PROTEIN LINKED RECEPTOR ANTAGONISTS FROM THE TROPICAL PLANT MARTINELLA-IQUITOSENSIS (BIGNONIACEAE)
Authors: WITHERUP KM RANSOM RW GRAHAM AC BERNARD AM SALVATORE MJ LUMMA WC ANDERSON PS PITZENBERGER SM VARGA SL
Citation: Km. Witherup et al., MARTINELLINE AND MARTINELLIC ACID, NOVEL G-PROTEIN LINKED RECEPTOR ANTAGONISTS FROM THE TROPICAL PLANT MARTINELLA-IQUITOSENSIS (BIGNONIACEAE), Journal of the American Chemical Society, 117(25), 1995, pp. 6682-6685
SYNTHESIS OF A SERIES OF ORO-4-CYCLOPROPYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES AS NOVEL NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS
Authors: TUCKER TJ LYLE TA WISCOUNT CM BRITCHER SF YOUNG SD SANDERS WM LUMMA WC GOLDMAN ME OBRIEN JA BALL RG HOMNICK CF SCHLEIF WA EMINI EA HUFF JR ANDERSON PS
Citation: Tj. Tucker et al., SYNTHESIS OF A SERIES OF ORO-4-CYCLOPROPYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES AS NOVEL NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS, Journal of medicinal chemistry, 37(15), 1994, pp. 2437-2444
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